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  1. 1981
    “…Activation of telomerase or alternative lengthening of telomeres (ALT) is necessary for tumours to escape from dysfunctional telomere-mediated senescence. …”
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    Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX
  2. 1982
    “…This review examines the current state of knowledge on and discusses the implications linked to telomere dysfunction and telomerase activation in the development and clinical outcome of HNSCC.…”
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    Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications
  3. 1983
    “…Multiple complexes protect telomeres. In telomerase-maintained organisms, Shelterin related complexes occupy the duplex region while the CST and Tpp1-Pot1 complexes bind the single stranded overhang of telomeres. …”
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    MTV, an ssDNA Protecting Complex Essential for Transposon-Based Telomere Maintenance in Drosophila
  4. 1984
    “…In humans and other animals, telomeres almost always shorten with age, with more rapid telomere attrition in short-lived species. …”
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    Telomeres are elongated in older individuals in a hibernating rodent, the edible dormouse (Glis glis)
  5. 1985
    “…Protection of telomeres (POT1) binds chromosome ends, recognizing single-strand telomeric DNA via two oligonucleotide/oligosaccharide binding folds (OB-folds). …”
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    Evolution of Arabidopsis protection of telomeres 1 alters nucleic acid recognition and telomerase regulation
  6. 1986
    “…Telomere stability is a hallmark of immortalized cells, including cancer cells. …”
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    ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2
  7. 1987
    “…Polychlorinated biphenyls (PCBs) are organochlorine pollutants with a worldwide dissemination. We examined telomere length (TL) in peripheral blood cells of 207 individuals with a high body burden of PCBs due to occupational exposure in a transformer recycling company. …”
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    Accelerated telomere shortening in peripheral blood lymphocytes after occupational polychlorinated biphenyls exposure
  8. 1988
    “…In budding yeast, telomerase and the Cdc13p protein are two key players acting to ensure telomere stability. In the absence of telomerase, cells eventually enter a growth arrest which only few can overcome via a conserved process; such cells are called survivors. …”
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    DNA damage checkpoint adaptation genes are required for division of cells harbouring eroded telomeres
  9. 1989
    “…Finally, we discuss the differences in telomere homeostasis between normal cells and cancer cells, which may provide a foundation for telomere/telomerase targeted cancer treatments.…”
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    Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells
  10. 1990
    “…The linear replicons are terminated by covalently closed hairpin (hp) telomeres. Hairpin telomeres are formed from replicated intermediates by the telomere resolvase, ResT, in a phosphoryl transfer reaction with mechanistic similarities to those promoted by type 1B topoisomerases and tyrosine recombinases. …”
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    The Borrelia burgdorferi telomere resolvase, ResT, possesses ATP-dependent DNA unwinding activity
  11. 1991
    “…Multiple G-quadruplex units in the 3΄-terminal overhang of human telomeric DNA can associate and form multimeric structures. …”
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    Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole
  12. 1992
    por Nettle, Daniel, Bateson, Melissa
    Publicado 2017
    “…Telomere shortening has emerged as an important biomarker of aging. …”
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    Detecting telomere elongation in longitudinal datasets: analysis of a proposal by Simons, Stulp and Nakagawa
  13. 1993
    “…These in vitro results suggest that formation of clustered lesions in the chromosome capping structure can result in the unfolding of existing G-quadruplexes which can lead to telomere shortening.…”
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    Clustered abasic lesions profoundly change the structure and stability of human telomeric G-quadruplexes
  14. 1994
    “…To prevent progressive telomere shortening as a result of conventional DNA replication, new telomeric DNA must be added onto the chromosome end. …”
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    CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance
  15. 1995
    “…We investigated the hypothesis of a link between altered inflammatory response, detected by plasmatic long pentraxin 3 (PTX3), and biological aging, measured by leukocyte telomere length (LTL), attrition, and possibly induced by night-shift work. …”
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    Inflammatory Long Pentraxin 3 is Associated with Leukocyte Telomere Length in Night-Shift Workers
  16. 1996
    “…Telomeres constitute the ends of linear chromosomes and together with the shelterin complex form a structure essential for genome maintenance and stability. …”
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    ZBTB48 is both a vertebrate telomere‐binding protein and a transcriptional activator
  17. 1997
    “…This meta-analysis examined the association between the level of childhood psychosocial stressors and telomere length, an important health biomarker. The meta-analysis, including 27 samples and 16,238 participants, found a significant association of -0.08 between a higher level of childhood stressors and shorter telomere length at a mean age of 42 across studies. …”
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    The Relationship Between Childhood Psychosocial Stressor Level and Telomere Length: A Meta-Analysis
  18. 1998
    “…Meditation is a tool to treat stress-related conditions and promote wellness. Telomere length may be affected by burnout and stress. …”
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    Effect of heartfulness meditation on burnout, emotional wellness, and telomere length in health care professionals
  19. 1999
    “…To explore the mechanisms that drive DNA damage–induced chromosome mobility, we use single-particle tracking of tagged chromosomal loci during interphase in live yeast cells together with polymer models of chromatin chains. Telomeres become mobilized from sites on the nuclear envelope and the pericentromere expands after exposure to DNA-damaging agents. …”
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    Microtubule dynamics drive enhanced chromatin motion and mobilize telomeres in response to DNA damage
  20. 2000
    “…The results show that the above-mentioned short telomere phenotype is not a consequence of an inability of telomerase to elongate telomeres when TTP synthesis is impaired. …”
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    Limited TTP supply affects telomere length regulation in a telomerase-independent fashion
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