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Mostrando 2,001 - 2,020 Resultados de 8,819 Para Buscar 'Telonero~', tiempo de consulta: 4.39s Limitar resultados
  1. 2001
    “…Given the potential role of telomeres as biomarkers of individual health and ageing, there is an increasing interest in studying telomere dynamics in a wider range of taxa in the fields of ecology and evolutionary biology. …”
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    Telomere length measurement by qPCR in birds is affected by storage method of blood samples
  2. 2002
    “…Telomere length has been suggested to be a cellular marker for age-related diseases as well as psychosocial stress. …”
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    The effect of trauma and PTSD on telomere length: An exploratory study in people exposed to combat trauma
  3. 2003
    “…Telomerase activity in the cells maintains telomere length and is implicated in ageing and various diseases wherein the shortening of telomere during ageing is controlled chiefly by the telomerase activity. …”
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    Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells
  4. 2004
    “…The mechanism of cellular aging likely involves decreased telomere length and is associated with age-related diseases such as cardiovascular disease. …”
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    Examining the gender difference in the association between metabolic syndrome and the mean leukocyte telomere length
  5. 2005
    “…[Image: see text] We have carried out a series of extended unbiased molecular dynamics (MD) simulations (up to 10 μs long, ∼162 μs in total) complemented by replica-exchange with the collective variable tempering (RECT) approach for several human telomeric DNA G-quadruplex (GQ) topologies with TTA propeller loops. …”
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    Exploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations
  6. 2006
    por Xiao, Chao-Da, Ishizuka, Takumi, Xu, Yan
    Publicado 2017
    “…In this study, by combining nuclear magnetic resonance (NMR), circular dichroism (CD), liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS), and gel electrophoresis, we report an unusual topological structure of the RNA G-quadruplex motif formed by human telomere RNA r(UAGGGU) containing 8-bromoguanosine. …”
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    Antiparallel RNA G-quadruplex Formed by Human Telomere RNA Containing 8-Bromoguanosine
  7. 2007
    por Wang, Hyewon, Kim, Hyungjo, Baik, Inkyung
    Publicado 2017
    “…BACKGROUND/OBJECTIVES: Telomere length is a useful biomarker for determining general aging status. …”
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    Associations of alcohol consumption and alcohol flush reaction with leukocyte telomere length in Korean adults
  8. 2008
    “…Shorter telomere length had a significant association (adjusted HR 0.18, p=0.001) with reduced survival in the combined cHP cohorts. …”
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    The MUC5B promoter polymorphism and telomere length in patients with chronic hypersensitivity pneumonitis
  9. 2009
    “…BACKGROUND: Cigarette smoking is a risk factor for ageing-related disease, but its association with biological ageing, indicated by telomere length, is unclear. METHODS: We systematically reviewed evidence evaluating association between smoking status and telomere length. …”
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    Cigarette smoking and telomere length: A systematic review of 84 studies and meta-analysis
  10. 2010
    “…Several methods have been employed to measure telomere length (TL) in human studies. It has been difficult to directly compare the results from these studies because of differences in the laboratory techniques and output parameters. …”
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    Correlation of Leukocyte Telomere Length Measurement Methods in Patients with Dyskeratosis Congenita and in Their Unaffected Relatives
  11. 2011
    “…Age-related hearing loss (ARHI) is the most common sensory disorder in the elderly. Although telomere attrition has been shown as a determinant in the pathobiology of various age-related diseases, it remains unknown whether telomere length is associated with ARHI. …”
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    Association of leukocyte telomere length and the risk of age-related hearing impairment in Chinese Hans
  12. 2012
    “…Telomeres, long nucleotide repeats and a protein complex at chromosome ends, shorten with each cell division and are susceptible to oxidative damage. …”
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    Effect of pre-analytic variables on the reproducibility of qPCR relative telomere length measurement
  13. 2013
    “…Age-related decline in immunity is characterized by stem cell exhaustion, telomere shortening, and disruption of cell-to-cell communication, leading to increased patient risk of disease. …”
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    Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?
  14. 2014
    “…We aimed to evaluate whether the FTO rs9939609 risk variant is independently associated with metabolic risk factors and/or leukocyte telomere length (LTL). We further aimed to investigate whether this relationship is modified by obesity status. …”
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    The FTO rs9939609 polymorphism is associated with short leukocyte telomere length in nonobese individuals
  15. 2015
    “…Here we show that protection of telomeres 1A (Pot1a), a component of the Shelterin complex that protects telomeres, improves haematopoietic stem cell (HSC) activity during aging. …”
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    The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age
  16. 2016
    “…Aging is considered the major risk factor for neurodegenerative diseases including Parkinson’s disease (PD). Telomere shortening is associated with cellular senescence. …”
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    CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation
  17. 2017
    “…While the mechanisms of telomere maintenance has been investigated in dividing cells, little is known about the stability of telomeres in quiescent cells and how dysfunctional telomeres are processed in non-proliferating cells. …”
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    Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences
  18. 2018
    “…Here, we demonstrate that AURKB localizes to the telomeres in mouse embryonic stem cells, where it interacts with the essential telomere protein TERF1. …”
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    Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity
  19. 2019
    “…Understanding individual‐level variation in response to the environment is fundamental to understanding life‐history evolution and population dynamics. Telomeres, the protective caps at the ends of chromosomes, shorten in response to oxidative stress, and telomere shortening is correlated with reduced survival and life span. …”
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    Spatio‐temporal variation in lifelong telomere dynamics in a long‐term ecological study
  20. 2020
    “…Notably, certain studies identfieid that lymphocytes of shortening telomere length have undergone apoptosis escape in autoimmune diseases. …”
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    The shortening telomere length of T lymphocytes maybe associated with hyper-function in servere aplastic anemia
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