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Mostrando 2,041 - 2,060 Resultados de 8,819 Para Buscar 'Telonero~', tiempo de consulta: 3.84s Limitar resultados
  1. 2041
    “…Telomeres protect against chromosomal damage. Accelerated telomere loss has been associated with premature aging syndromes such as Werner’s syndrome and Dyskeratosis Congenita, while, progressive telomere loss activates a DNA damage response leading to chromosomal instability, typically observed in cancer cells and senescent cells. …”
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    hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction
  2. 2042
    “…The increasing interest in studying biomolecules under more cellular-like conditions prompted us to investigate the effect of osmotic stress on the structural and thermodynamic properties of DNA oligomers containing the human telomere sequence (TTAGGG). Here, we report the characterization of (TTAGGG)(4) in potassium phosphate buffer with increasing percent PEG (polyethylene glycol) or acetonitrile. …”
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    The Human Telomere Sequence, (TTAGGG)(4), in the Absence and Presence of Cosolutes: A Spectroscopic Investigation
  3. 2043
    “…Because stabilization of GQs at telomeres and oncogene promoters may prevent cancer, there is an interest in developing small molecules that selectively target GQs. …”
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    Interactions Between Spermine-Derivatized Tentacle Porphyrins and The Human Telomeric DNA G-Quadruplex
  4. 2044
    “…Like FLO genes in S. cerevisiae, FAS genes are mostly telomeric with several paralogs at each telomere. We term such genes that share evolutionary conserved telomere localization “telologs” and provide several other examples. …”
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    Expansion of a Telomeric FLO/ALS-Like Sequence Gene Family in Saccharomycopsis fermentans
  5. 2045
    “…Here, we show that Pold3 plays important roles in DSB repair, telomere maintenance and genomic stability of both ESCs and spermatocytes in mice. …”
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    Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis
  6. 2046
    “…Shortened leukocyte and placental telomeres associated with gestational diabetes mellitus (GDM) suggest this exposure triggers telomere attrition contributing to adverse outcomes. …”
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    Metformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes
  7. 2047
    “…OBJECTIVE: The study aimed to explore the relationship of the telomere length with type 2 diabetes mellitus (DM) among patients with ischemic heart disease (IHD). …”
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    Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease
  8. 2048
    “…Epidemiological studies suggest that stressors experienced by parents affect the longevity of their offspring, possibly by regulating telomere dynamics. Telomeres are elongated by telomerase and shortened by certain stresses as well as telomere repeat-containing RNA (TERRA), a telomere transcript. …”
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    Telomere shortening by transgenerational transmission of TNF-α-induced TERRA via ATF7
  9. 2049
    “…In human cells, telomeres are elongated by the telomerase complex that contains the reverse transcriptase hTERT and RNA template TERC/hTR. …”
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    TOE1 acts as a 3′ exonuclease for telomerase RNA and regulates telomere maintenance
  10. 2050
    “…BACKGROUND/OBJECTIVES: Telomere shortening plays an important role in cellular aging. …”
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    High sodium intake is associated with short leukocyte telomere length in overweight and obese adolescents
  11. 2051
    “…Telomeres, the protective structures at the ends of chromosomes, can be shortened when individuals are exposed to stress. …”
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    Exposure to environmental radionuclides associates with tissue-specific impacts on telomerase expression and telomere length
  12. 2052
    “…During meiotic prophase I, telomeres attach to and move on the nuclear envelope (NE), regulating chromosome movement to promote homologous pairing. …”
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    The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope
  13. 2053
    “…Introduction: Telomere length (TL) is causally related to aging and several age-related diseases. …”
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    Developing BIOTEL: A Semi-Automated Spreadsheet for Estimating Telomere Length and Biological Age
  14. 2054
    “…Telomeres and telomerase provide a unique and important avenue of study in improving both life expectancy and quality of life due to their close association with aging and disease. …”
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    Targeting Telomeres and Telomerase: Studies in Aging and Disease Utilizing CRISPR/Cas9 Technology
  15. 2055
    “…Experience of the local residential environment is important for health although few studies have examined this in relation to biological markers of age such as telomere length. We sought to examine if residents’ perceptions of neighbourhood stressors over time were associated with telomere length in a community study. …”
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    More miles on the clock: Neighbourhood stressors are associated with telomere length in a longitudinal study
  16. 2056
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    Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion
  17. 2057
    “…Our study showed an inverse correlation between telomere length and coal exposure in addition to an increase in DNA damage. …”
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    Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure
  18. 2058
    “…Introduction: Physical activity (PA) has been associated with telomere shortening. The association of PA intensity or volume with telomere length (TL) is nonetheless unclear. …”
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    Association of Physical Activity With Telomere Length Among Elderly Adults - The Oulu Cohort 1945
  19. 2059
    “…In the present study, we report that oocytes and embryos from aged mice (42-45 weeks old) display the reduced expression of SIRT6 protein, accompanying with telomere shortening and DNA lesions. Moreover, we demonstrate that specific depletion of SIRT6 in oocytes induces dysfunctional telomeres and apoptosis of the resultant early embryos, leading to the developmental delay and cytoplasmic fragmentation. …”
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    SIRT6 participates in the quality control of aged oocytes via modulating telomere function
  20. 2060
    “…Background: The human telomerase reverse transcriptase (TERT) gene encodes the catalytic subunit of telomerase that is essential for maintenance of telomere length. We aimed to find out whether variability within the TERT gene could be associated with telomere length and development of the disease in non-treated patients with chronic lymphocytic leukemia (CLL). …”
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    Variability within the human TERT gene, telomere length and predisposition to chronic lymphocytic leukemia
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