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2061
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2062por Al Khleifat, Ahmad, Iacoangeli, Alfredo, Shatunov, Aleksey, Fang, Ton, Sproviero, William, Jones, Ashley R., Opie-Martin, Sarah, Morrison, Karen E., Shaw, Pamela J., Shaw, Christopher E., Powell, John F., Dobson, Richard, Newhouse, Steven J., Al-Chalabi, Ammar“…Gender and age are risk factors for ALS and also associated with telomere length. We therefore investigated telomere length in ALS. …”
Publicado 2019
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2063por Singchat, Worapong, Kraichak, Ekaphan, Tawichasri, Panupong, Tawan, Tanapong, Suntronpong, Aorarat, Sillapaprayoon, Siwapech, Phatcharakullawarawat, Rattanin, Muangmai, Narongrit, Suntrarachun, Sunutcha, Baicharoen, Sudarath, Punyapornwithaya, Veerasak, Peyachoknagul, Surin, Chanhome, Lawan, Srikulnath, Kornsorn“…Telomeres comprise tandem repeated DNA sequences that protect the ends of chromosomes from deterioration or fusion with neighboring chromosomes, and their lengths might vary with sex and age. …”
Publicado 2019
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2064por Nguyen, Minh Thien, Vryer, Regan, Ranganathan, Sarath, Lycett, Kate, Grobler, Anneke, Dwyer, Terence, Juonala, Markus, Saffery, Richard, Burgner, David, Wake, Melissa“…BACKGROUND: Telomere length has been inversely associated with cardiovascular disease in adulthood, but its relationship to preclinical cardiovascular phenotypes across the life course remains unclear. …”
Publicado 2019
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2065
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2066por Ji, Yingjie, Dang, Xindi, Nguyen, Lam Ngoc Thao, Nguyen, Lam Nhat, Zhao, Juan, Cao, Dechao, Khanal, Sushant, Schank, Madison, Wu, Xiao Y., Morrison, Zheng D., Zou, Yue, El Gazzar, Mohamed, Ning, Shunbin, Wang, Ling, Moorman, Jonathan P., Yao, Zhi Q.“…Here, we used CD4 T cells derived from individuals with chronic viral infections or healthy T cells treated with camptothecin (CPT) - a topoisomerase I (Top 1) inhibitor - as a model to investigate the role of DNA topology in reprogramming telomeric DNA damage responses (DDR) and remodeling T cell functions. …”
Publicado 2019
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2067“…Telomere length (TL) is a marker of cellular and biological aging. …”
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2068por He, Caixia, Jing, Shuang, Dai, Congling, Tu, Chaofeng, Tan, Zhenhua, Du, Juan, Lu, Guang‐Xiu, Lin, Ge, Zeng, Sicong“…BACKGROUND: Dyskeratosis congenita (DC) is a rare heritable bone marrow failure syndrome that is associated with telomere dysfunction, and has high genetic heterogeneity and varied features. …”
Publicado 2019
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2069por Keng, Shian-Ling, Yim, Onn Siong, Lai, Poh San, Chew, Soo Hong, Ebstein, Richard P.“…The present study aimed to examine the relationship between leukocyte telomere length (LTL), an index of cellular aging, dispositional mindfulness, and self-compassion in a sample of Singaporean Chinese adults. …”
Publicado 2019
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2070por Carugno, Michele, Maggioni, Cristina, Crespi, Eleonora, Bonzini, Matteo, Cuocina, Simone, Dioni, Laura, Tarantini, Letizia, Consonni, Dario, Ferrari, Luca, Pesatori, Angela Cecilia“…We assessed the association between NS work and DNA methylation of tumor suppressor (TP53, CDKN2A, BRCA1, BRCA2) and estrogen receptor (ESR1, ESR2) genes, methylation of repetitive elements (LINE-1, Alu), and telomere length (TL). Forty six female nurses employed in NS for at least two years were matched by age (30–45 years) and length of service (≥1 year) with 51 female colleagues not working in NS. …”
Publicado 2019
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2071por Yu, Pak Lok Ivan, Wang, Rachel R., Johnston, Grace, Wang, Yaqiong, Tammur, Pille, Tamm, Anu, Punab, Mari, Rangel-Pozzo, Aline, Mai, Sabine“…Previous research has indicated that 3D nuclear telomeric and centromeric organization may represent important structural indicators for numerous malignancies. …”
Publicado 2019
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2072por Parolini, Marco, Possenti, Cristina Daniela, Romano, Andrea, Caprioli, Manuela, Rubolini, Diego, Saino, Nicola“…In birds, rapid postnatal growth and sudden exposure to aerial oxygen around hatching markedly affect the chick redox status, with potentially negative consequences on physiology mediated by oxidative stress. In addition, telomere length (TL) undergoes reduction during birds’ early life, partly depending on oxidative status. …”
Publicado 2019
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2073por Spindler, Marie-Christin, Redolfi, Josef, Helmprobst, Frederik, Kollmannsberger, Philip, Stigloher, Christian, Benavente, Ricardo“…Telomere movements during meiotic prophase I facilitate synapsis and recombination of homologous chromosomes. …”
Publicado 2019
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2074“…The resulting T/S ratio (telomere to single copy) is proportional to the average telomere length. …”
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2075por Allsopp, Richard, Davy, Philip, Willcox, Craig, Chen, Randi, Shimabukuro, Michio, de Vivo, Immaculata, Willcox, Bradley J“…Telomere attrition in proliferative tissues is a hallmark feature of human aging. …”
Publicado 2019
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2076por Nersisyan, Lilit, Hopp, Lydia, Loeffler-Wirth, Henry, Galle, Jörg, Loeffler, Markus, Arakelyan, Arsen, Binder, Hans“…Background: Activation of telomere maintenance mechanisms (TMMs) is a hallmark of most cancers, and is required to prevent genome instability and to establish cellular immortality through reconstitution of capping of chromosome ends. …”
Publicado 2019
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2077por Giri, Neelam, Ravichandran, Sandhiya, Wang, Youjin, Gadalla, Shahinaz M., Alter, Blanche P., Fontana, Joseph, Savage, Sharon A.“…Pulmonary fibrosis and pulmonary arteriovenous malformations are known manifestations of dyskeratosis congenita (DC), a telomere biology disorder (TBD) and inherited bone marrow failure syndrome caused by germline mutations in telomere maintenance genes resulting in very short telomeres. …”
Publicado 2019
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2078por Gu, Cheng-Yuan, Jin, Sheng-Ming, Qin, Xiao-Jian, Zhu, Yao, Bo, Dai, Lin, Guo-Wen, Shi, Guo-Hai, Ye, Ding-Wei“…Telomere length measured in lymphocytes has been evaluated as a potential biomarker for prostate cancer (PCa) risk. …”
Publicado 2019
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2079por HUBACEK, Jaroslav A., PELCLOVA, Daniela, DLOUHA, Dana, MIKUSKA, Pavel, DVORACKOVA, Stepanka, VLCKOVA, Stepanka, FENCLOVA, Zdenka, ONDRACEK, Jakub, KOSTEJN, Martin, SCHWARZ, Jaroslav, POPOV, Alex, KRUMAL, Kamil, LANSKA, Vera, COUFALIK, Pavel, ZAKHAROV, Sergej, ZDIMAL, Vladimir“…Our pilot results suggest that relative leukocyte telomere length is not affected by occupational exposure to nanoparticles.…”
Publicado 2019
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2080por Cao, Xuguang, Huang, Mingtao, Zhu, Meng, Fang, Rui, Ma, Zijian, Jiang, Tao, Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Shen, Hongbing, Du, Jiangbo, Xu, Lin, Hu, Zhibin“…Associations between telomere length and cancer risk have been investigated in many epidemiological studies, but the results are controversial. …”
Publicado 2019
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