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Mostrando 2,081 - 2,100 Resultados de 8,819 Para Buscar 'Telonero~', tiempo de consulta: 4.33s Limitar resultados
  1. 2081
    “…BACKGROUND: The present protocol was designed for a systematic review and meta-analysis aimed at determining the association of telomere length with substance use disorders with the exclusion of nicotine addiction, and to identify potential moderators of the effect of telomere length. …”
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    The association of telomere length with substance use disorders: systematic review and meta-analysis protocol
  2. 2082
    “…Telomeres cap the physical ends of eukaryotic chromosomes to ensure complete DNA replication and genome stability. …”
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    Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis
  3. 2083
    “…Reported associations between leukocyte telomere length (LTL) attrition, diet and cardiovascular disease (CVD) are inconsistent. …”
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    Diet-induced leukocyte telomere shortening in a baboon model for early stage atherosclerosis
  4. 2084
    “…Cancer cells maintain their telomeres by either re-activating telomerase or adopting the homologous recombination (HR)-based Alternative Lengthening of Telomere (ALT) pathway. …”
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    FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops
  5. 2085
    “…We evaluated the contribution of telomere length in pathogenesis in 361 DM1 patients (12 with serial measurements) and 223 unaffected relative controls using qPCR assay. …”
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    Leukocyte telomere length in patients with myotonic dystrophy type I: a pilot study
  6. 2086
    “…Mechanistically, we show that ATRX affects telomeric DSB repair by promoting cohesion of sister telomeres and that loss of ATRX in ALT cells results in diminished telomere cohesion. …”
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    ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity
  7. 2087
    “…The underlying mechanism for this protective effect may be that folic acid decreased oxidative stress and thereby prevented telomeric DNA oxidative damage and telomere attrition.…”
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    Folic Acid Decreases Astrocyte Apoptosis by Preventing Oxidative Stress-Induced Telomere Attrition
  8. 2088
    “…BACKGROUND: Telomeres play important roles in cancer initiation and progression. …”
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    Leukocyte telomere length is associated with aggressive prostate cancer in localized prostate cancer patients
  9. 2089
    “…Using an unbiased genetic screen, we identified SLX4-interacting protein (SLX4IP) as a regulator of metastatic recurrence and established its relationship in governing telomere maintenance mechanisms (TMMs). Inactivation of SLX4IP suppressed alternative lengthening of telomeres (ALT), coinciding with activation of telomerase. …”
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    SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsiveness
  10. 2090
    por Li, Chen, Stoma, Svetlana, Lotta, Luca A., Warner, Sophie, Albrecht, Eva, Allione, Alessandra, Arp, Pascal P., Broer, Linda, Buxton, Jessica L., Da Silva Couto Alves, Alexessander, Deelen, Joris, Fedko, Iryna O., Gordon, Scott D., Jiang, Tao, Karlsson, Robert, Kerrison, Nicola, Loe, Taylor K., Mangino, Massimo, Milaneschi, Yuri, Miraglio, Benjamin, Pervjakova, Natalia, Russo, Alessia, Surakka, Ida, van der Spek, Ashley, Verhoeven, Josine E., Amin, Najaf, Beekman, Marian, Blakemore, Alexandra I., Canzian, Federico, Hamby, Stephen E., Hottenga, Jouke-Jan, Jones, Peter D., Jousilahti, Pekka, Mägi, Reedik, Medland, Sarah E., Montgomery, Grant W., Nyholt, Dale R., Perola, Markus, Pietiläinen, Kirsi H., Salomaa, Veikko, Sillanpää, Elina, Suchiman, H. Eka, van Heemst, Diana, Willemsen, Gonneke, Agudo, Antonio, Boeing, Heiner, Boomsma, Dorret I., Chirlaque, Maria-Dolores, Fagherazzi, Guy, Ferrari, Pietro, Franks, Paul, Gieger, Christian, Eriksson, Johan Gunnar, Gunter, Marc, Hägg, Sara, Hovatta, Iiris, Imaz, Liher, Kaprio, Jaakko, Kaaks, Rudolf, Key, Timothy, Krogh, Vittorio, Martin, Nicholas G., Melander, Olle, Metspalu, Andres, Moreno, Concha, Onland-Moret, N. Charlotte, Nilsson, Peter, Ong, Ken K., Overvad, Kim, Palli, Domenico, Panico, Salvatore, Pedersen, Nancy L., Penninx, Brenda W.J. H., Quirós, J. Ramón, Jarvelin, Marjo Riitta, Rodríguez-Barranco, Miguel, Scott, Robert A., Severi, Gianluca, Slagboom, P. Eline, Spector, Tim D., Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, Uitterlinden, André G., van der Schouw, Yvonne T., van Duijn, Cornelia M., Weiderpass, Elisabete, Denchi, Eros Lazzerini, Matullo, Giuseppe, Butterworth, Adam S., Danesh, John, Samani, Nilesh J., Wareham, Nicholas J., Nelson, Christopher P., Langenberg, Claudia, Codd, Veryan
    Publicado 2020
    “…Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. …”
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    Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length
  11. 2091
    “…Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among participants with BD at early and late stages and age- and gender-matched healthy controls. …”
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    Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease
  12. 2092
    “…Telomeres which are present at the ends of eukaryotic chromosomes mediate genome stability and determine cellular lifespan(1). …”
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    RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops
  13. 2093
    “…Repressor/activator protein 1 (RAP1) is a highly evolutionarily conserved protein found at telomeres. Although yeast Rap1 is a key telomere capping protein preventing non‐homologous end joining (NHEJ) and consequently telomere fusions, its role at mammalian telomeres in vivo is still controversial. …”
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    Human RAP1 specifically protects telomeres of senescent cells from DNA damage
  14. 2094
    “…IMPORTANCE: Leukocyte telomere length (LTL) is a trait associated with risk of cardiovascular disease and cancer, the 2 major disease categories that largely define longevity in the United States. …”
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    Association of Leukocyte Telomere Length With Mortality Among Adult Participants in 3 Longitudinal Studies
  15. 2095
    “…Nuclear targets of Ccr4 mainly comprise active full-length transposable elements (TEs) and telomeric and subtelomeric repeats. Moreover, Ccr4-Not foci localize at telomeres in a Piwi-dependent manner, suggesting a functional relationship between these pathways. …”
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    Nuclear Ccr4-Not mediates the degradation of telomeric and transposon transcripts at chromatin in the Drosophila germline
  16. 2096
    “…In TGS1 mutant cells, increased hTR assembles with telomerase reverse transcriptase (TERT) protein to yield elevated active telomerase complexes and increased telomerase activity, resulting in telomere elongation in cultured human cells. Our results show that TGS1-mediated hypermethylation of the hTR cap inhibits hTR accumulation, restrains levels of assembled telomerase, and limits telomere elongation.…”
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    Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation
  17. 2097
    “…Here, we show that fission yeast Aurora B localizes at telomeres during meiosis I and promotes telomere separation independently of the meiotic cohesin Rec8. …”
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    Aurora B and condensin are dispensable for chromosome arm and telomere separation during meiosis II
  18. 2098
    “…Telomeres are maintained by telomerase or in a subset of cancer cells by a homologous recombination (HR)-based mechanism, Alternative Lengthening of Telomeres (ALT). …”
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    ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization
  19. 2099
    “…G-quadruplexes are four-stranded nucleic acid structures involved in multiple cellular pathways including DNA replication and telomere maintenance. Such structures are formed by G-rich DNA sequences typified by telomeric DNA repeats. …”
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    Structural basis of G-quadruplex DNA recognition by the yeast telomeric protein Rap1
  20. 2100
    “…Individuals in free‐living animal populations generally differ substantially in reproductive success, lifespan and other fitness‐related traits, but the molecular mechanisms underlying this variation are poorly understood. Telomere length and dynamics are candidate traits explaining this variation, as long telomeres predict a higher survival probability and telomere loss has been shown to reflect experienced “life stress.” …”
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    Sex‐specific telomere length and dynamics in relation to age and reproductive success in Cory’s shearwaters
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