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Mostrando 2,101 - 2,120 Resultados de 8,819 Para Buscar 'Telonero~', tiempo de consulta: 3.01s Limitar resultados
  1. 2101
    “…The telomere G‐tail (G‐tail) plays an essential role in maintaining chromosome stability. …”
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    Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer
  2. 2102
    “…The dynamic topological structure of telomeric DNA is closely related to its biological function; however, no such structural information on full-length telomeric DNA has been reported due to difficulties synthesizing long double-stranded telomeric DNA. …”
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    Dynamic topology of double-stranded telomeric DNA studied by single-molecule manipulation in vitro
  3. 2103
    “…Humanized cancer-free NBS mice had normal TL. Telomere elongation was inducible by telomerase and/or alternative telomere lengthening but was associated with abnormal expression of telomeric genes involved in aging and/or cell growth. …”
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    Telomere attrition and dysfunction: a potential trigger of the progeroid phenotype in nijmegen breakage syndrome
  4. 2104
    “…Telomeres cap the ends of eukaryotic chromosomes and distinguish them from broken DNA ends to suppress DNA damage response, cell cycle arrest and genomic instability. …”
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    Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomerase
  5. 2105
    “…Telomere maintenance mechanisms (TMM) are used by cancer cells to avoid apoptosis, 85–90% reactivate telomerase, while 10–15% use the alternative lengthening of telomeres (ALT). …”
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    TCGA Pan-Cancer Genomic Analysis of Alternative Lengthening of Telomeres (ALT) Related Genes
  6. 2106
    “…Failure to maintain heterochromatin increases spurious transcription of repetitive elements and induces features of alternative lengthening of telomeres (ALT). TLK depletion culminates in a cGAS-STING-TBK1-mediated innate immune response that is independent of replication-stress signaling and attenuated by the depletion of factors required to produce extra-telomeric DNA. …”
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    Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres
  7. 2107
    “…Protection of telomere 1 (POT1), the telomeric single-stranded DNA (ssDNA)-binding protein in the shelterin complex, has been implicated in the DNA damage response, tumorigenesis and aging. …”
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    MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence
  8. 2108
    “…Telomere length is a promising biomarker for age-associated diseases and cancer, but there are still substantial challenges to routine telomere analysis in clinics because of the lack of a simple and rapid yet scalable method for measurement. …”
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    Massively parallel single-molecule telomere length measurement with digital real-time PCR
  9. 2109
    “…Chromothripsis and kataegis are frequently observed in cancer and may arise from telomere crisis, a period of genome instability during tumorigenesis when depletion of the telomere reserve generates unstable dicentric chromosomes(1–5). …”
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    APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis
  10. 2110
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    Editorial: Proceedings From ACCM19: Cell Cycle, DNA Damage Response and Telomeres
  11. 2111
    “…BACKGROUND: Telomeres shorten as organisms age, placing limits on cell proliferation and serving as a marker of biological aging. …”
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    Non-esterified fatty acids and telomere length in older adults: The Cardiovascular Health Study
  12. 2112
    “…These findings complement emerging literature suggesting that augmented telomere maintenance is important in ependymoma pathogenesis and progression, and that longer telomere length is a risk factor for diverse nervous system malignancies.…”
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    Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma
  13. 2113
    “…Resulting erosion of telomeres leads eventually to replicative senescence. …”
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    Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction
  14. 2114
    “…Oxidative stress and inflammation play vital roles in Parkinson’s disease (PD) development. Thus, telomere length is expected to be shortened in this disease, but current data are inconclusive. …”
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    Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's disease
  15. 2115
    por Torrance, Jerry B., Goldband, Steve
    Publicado 2020
    “…Many researchers have focused on telomeres, which are composed of a series of TTAGGG repeat nucleotide sequences at the ends of each chromosome. …”
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    Mathematical Connection between Short Telomere Induced Senescence Calculation and Mortality Rate Data
  16. 2116
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    Functional validation of TERT and TERC variants of uncertain significance in patients with short telomere syndromes
  17. 2117
    “…Mutations in the telomere-binding protein POT1 are associated with solid tumors and leukemias. …”
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    Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore
  18. 2118
    “…Subsets of pediatric cancers, including high grade glioma (pHGG), have high rates of uniquely long telomeres, associated with ATRX gene mutations and alternative lengthening of telomeres (ALT). …”
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    PATH-21. TELOMERE LENGTH ANALYSIS OF CNS TUMORS IN THE PEDIATRIC BRAIN TUMOR ATLAS
  19. 2119
    por Hastings, Waylon, Shalev, Idan
    Publicado 2020
    “…Epidemiological literature has produced robust associations between telomere length (TL) and health, wherein individuals with shorter TL are at increased risk for chronic disease and death. …”
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    Uninterruptible Power Supply Improves Precision of Telomere Length Measurement via qPCR
  20. 2120
    “…IPF patients are frequently identified with short telomeres but coding mutations in telomerase can only explain a minority of cases. …”
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    Relation between sex hormones and leucocyte telomere length in men with idiopathic pulmonary fibrosis
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