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Mostrando 2,241 - 2,260 Resultados de 8,819 Para Buscar 'Telonero~', tiempo de consulta: 6.76s Limitar resultados
  1. 2241
    “…Spaceflight-induced changes in astronaut telomeres have garnered significant attention in recent years. …”
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    Arabidopsis telomerase takes off by uncoupling enzyme activity from telomere length maintenance in space
  2. 2242
    “…RecQ DNA helicases, including yeast Sgs1p and the human Werner and Bloom syndrome proteins, participate in telomere biology, but the underlying mechanisms are not fully understood. …”
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    Evidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence
  3. 2243
    “…Intramolecular G-quadruplexes formed by the human telomeric G-rich strand are promising anticancer targets. …”
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    Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K(+) solution
  4. 2244
    por Tang, Xie, Jin, Ye, Cande, W. Zacheus
    Publicado 2006
    “…The telomere bouquet, i.e., telomere clustering on the nuclear envelope (NE) during meiotic prophase, is thought to promote homologous chromosome pairing. …”
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    Bqt2p is essential for initiating telomere clustering upon pheromone sensing in fission yeast
  5. 2245
    “…Here we describe the derivation of two biallelic polymorphisms from the 17p telomeric yeast artificial chromosome (YAC) TYAC98. …”
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    High levels of loss at the 17p telomere suggest the close proximity of a tumour suppressor.
  6. 2246
    “…Analysis of J and telomeric repeat sequences by J immunoblots and Southern blots following DNA digestion, reveals ∼25% of J outside the telomeric repeat sequences. …”
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    Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi
  7. 2247
    “…Intramolecular G-quadruplexes formed by human telomere sequences are attractive anticancer targets. …”
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    Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K(+) solution(†)
  8. 2248
    “…Budding yeast centromeres cluster near the spindle pole body, whereas telomeres are grouped in five to eight perinuclear foci. …”
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    Chromosome looping in yeast: telomere pairing and coordinated movement reflect anchoring efficiency and territorial organization
  9. 2249
    por Xu, Lifeng, Blackburn, Elizabeth H.
    Publicado 2004
    “…We identified and characterized a human orthologue of Rif1 protein, which in budding yeast interacts in vivo with the major duplex telomeric DNA binding protein Rap1p and negatively regulates telomere length. …”
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    Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules
  10. 2250
    “…Fluorescent in situ hybridization and three-dimensional fluorescence microscopy revealed that ring MCs did not participate in meiotic telomere clustering while MC homologues paired at the XY-body periphery. …”
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    Telomere-independent homologue pairing and checkpoint escape of accessory ring chromosomes in male mouse meiosis
  11. 2251
    por Carlton, Peter M., Cande, W. Zacheus
    Publicado 2002
    “…We find that: (a) the healed ends of broken chromosomes, which contain telomere repeats, can enter the bouquet; (b) ring chromosomes enter the bouquet, indicating that terminal position on a chromosome is not necessary for telomere sequences to localize to the bouquet; and (c) beginning at zygotene, the behavior of telomeres is dominant over any centromere-mediated chromosome behavior. …”
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    Telomeres act autonomously in maize to organize the meiotic bouquet from a semipolarized chromosome orientation
  12. 2252
    “…High-dose chemotherapy and peripheral blood stem cell transplantation (PBSCT) may accelerate telomere length loss in haematopoietic stem cells. …”
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    Telomere length in breast cancer patients before and after chemotherapy with or without stem cell transplantation
  13. 2253
    “…In these cases, the telomere repeat sequences were abnormally short and chromosomal breakage–fusion–bridge events were observed at cell division, as well as multipolar configurations and supernumerary centrosomes. …”
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    Telomere shortening and mitotic dysfunction generate cytogenetic heterogeneity in a subgroup of renal cell carcinomas
  14. 2254
    “…Appropriate control of the chromosome end-replicating enzyme telomerase is crucial for maintaining telomere length and genomic stability. The essential telomeric DNA-binding protein Cdc13p both positively and negatively regulates telomere length in budding yeast. …”
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    Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p
  15. 2255
    “…Recently, the human telomeric d[TAGGG(TTAGGG)(3)] sequence has been shown to form in K(+) solution an intramolecular (3+1) G-quadruplex structure, whose G-tetrad core contains three strands oriented in one direction and the fourth in the opposite direction. …”
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    A novel chair-type G-quadruplex formed by a Bombyx mori telomeric sequence
  16. 2256
    “…Tumours and immortalized cells avoid telomere attrition by using either the ribonucleoprotein enzyme telomerase or a recombination-based alternative lengthening of telomeres (ALT) mechanism. …”
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    Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription
  17. 2257
    “…Recent data have shown that oxidative stress is also responsible for the acceleration of human fibroblast telomere shortening in vitro. In the present study we analyzed the potential relations occurring between free radicals formation and telomere length during HIV-1 mediated astroglial death. …”
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    Apoptosis and telomeres shortening related to HIV-1 induced oxidative stress in an astrocytoma cell line
  18. 2258
    “…OBJECTIVE: High oxidative stress potentially leads to accelerated telomere shortening and consequent premature cell senescence, implicated in type 2 diabetes (T2D) development. …”
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    Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation
  19. 2259
    “…The processive telomerase action relies upon a template translocation mechanism whereby the RNA template and the telomeric DNA strand separate and realign between each repeat synthesis. …”
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    A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity
  20. 2260
    “…The importance of telomeric proteins for telomere maintenance has increased our interest in the identification of homologues within the genus Leishmania. …”
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    The Leishmania amazonensis TRF (TTAGGG repeat-binding factor) homologue binds and co-localizes with telomeres
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