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  1. 2341
    “…Telomere dysfunction participates in malignant transformation and tumorigenesis. …”
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    Telomere length, genetic variants and risk of squamous cell carcinoma of the head and neck in Southeast Chinese
  2. 2342
    “…DNA telomere shortening associates with the age-related increase cardiovascular disease (CVD) risk. …”
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    n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease
  3. 2343
    “…Evidence for an association of leukocyte telomere length (LTL) with cognitive function, predominantly in older adults, is inconsistent. …”
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    Increased attrition of leukocyte telomere length in young adults is associated with poorer cognitive function in midlife
  4. 2344
    “…Interestingly, RingoA is required for Cdk2 targeting to telomeres and RingoA KO spermatocytes display severely affected telomere tethering as well as impaired distribution of Sun1, a protein essential for the attachment of telomeres to the nuclear envelope. …”
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    Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope
  5. 2345
    “…Measurement of telomere length is widely used in epidemiologic studies. …”
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    Influence of DNA extraction methods on relative telomere length measurements and its impact on epidemiological studies
  6. 2346
    por Lee, Won Kyung, Cho, Myeon Haeng
    Publicado 2016
    “…Telomeres are nucleoprotein complexes at the end of eukaryotic chromosomes. …”
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    Telomere-binding protein regulates the chromosome ends through the interaction with histone deacetylases in Arabidopsis thaliana
  7. 2347
    “…To investigate the prognostic value of these mutations and telomere length, individually and their coexistence, in gliomas, we analyzed two somatic mutations C228T and C250T in the TERT promoter, relative telomere length (RTL), IDH1 mutation and MGMT methylation in 389 glioma patients, and explored their associations with patient characteristics and clinical outcomes. …”
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    TERT promoter mutations and long telomere length predict poor survival and radiotherapy resistance in gliomas
  8. 2348
    “…We show that telomerase activity and cardiomyocyte telomere length decrease sharply in wild-type mouse hearts after birth, resulting in cardiomyocytes with dysfunctional telomeres and anaphase bridges and positive for the cell-cycle arrest protein p21. …”
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    Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation
  9. 2349
    “…These effects of As(2)O(3) trigger an extensive DNA damage response at the telomere, which includes up-regulation of ATM, ATR, 53BP1, γ-H(2)AX and Mer11, in parallel with telomere fusion and 3′-overhang degradation. …”
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    Arsenic trioxide inhibits glioma cell growth through induction of telomerase displacement and telomere dysfunction
  10. 2350
    “…By mapping genome replication dynamics, we reveal that the transcribed VSG expression site is the only telomeric site that is early replicating – a differential timing only seen in mammal-infective parasites. …”
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    Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation
  11. 2351
    “…Telomere maintenance is a hallmark of cancer as it provides cancer cells with cellular immortality. …”
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    Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition
  12. 2352
    “…The role of telomere dysfunction in neurological diseases and the ageing brain is not clarified and there is an ongoing discussion whether telomere shortening is linked to Parkinson’s disease. …”
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    Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model
  13. 2353
    “…Short or damaged telomeres have been implicated in degenerative conditions. …”
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    Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects
  14. 2354
    “…Reduction in telomere-associated Smc5/6 leads to defects in telomere clustering, dispersion of the silencing factor, Sir4, and a loss in transcriptional repression for sub-telomeric genes and non-coding telomeric repeat-containing RNA (TERRA). …”
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    Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE
  15. 2355
    “…We studied the impact of hibernation and food supply on relative telomere length (RTL), an indicator for aging and somatic maintenance, in free-living edible dormice. …”
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    Telomere dynamics in free-living edible dormice (Glis glis): the impact of hibernation and food supply
  16. 2356
    “…AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression. …”
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    The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence
  17. 2357
    “…UCP2 polymorphisms are associated with leukocyte telomere length (LTL) in Type 2 Diabetes, which also induces considerable background oxidative stress. …”
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    Interactions between UCP2 SNPs and telomere length exist in the absence of diabetes or pre-diabetes
  18. 2358
    “…We used quantitative PCR to measure telomere length using peripheral blood genomic DNA. …”
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    Oxidative Stress-induced Telomere Length Shortening of Circulating Leukocyte in Patients with Obstructive Sleep Apnea
  19. 2359
    “…Dysfunctional telomeres and DNA damage repair (DDR) play important roles in cancer progression. …”
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    ERCC1 and telomere status in breast tumours treated with neoadjuvant chemotherapy and their association with patient prognosis
  20. 2360
    por Rasgon, N, Lin, K W, Lin, J, Epel, E, Blackburn, E
    Publicado 2016
    “…We studied peripheral leukocyte telomere length (LTL) as a predictor of antidepressant response to PPAR-γ agonist in patients with unremitted depression. …”
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    Telomere length as a predictor of response to Pioglitazone in patients with unremitted depression: a preliminary study
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