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Mostrando 221 - 240 Resultados de 8,819 Para Buscar 'Telonero~', tiempo de consulta: 3.91s Limitar resultados
  1. 221
    “…In addition to its role in telomeric heterochromatin assembly, Tls1-mediated splicing of shelterin mRNAs also regulates telomere length. …”
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    Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length
  2. 222
    “…While global chromatin conformation studies are emerging, very little is known about the chromatin conformation of human telomeres. Most studies have focused on the role of telomeres as a tumor suppressor mechanism. …”
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    Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances
  3. 223
    “…There are two basic mechanisms that are associated with the maintenance of the telomere length, which endows cancer cells with unlimited proliferative potential. …”
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    Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA
  4. 224
    “…Here we report that TRF2 overexpression results in replication stalling in duplex telomeric repeat tracts and the subsequent formation of telomeric ultrafine anaphase bridges (UFBs), ultimately leading to stochastic loss of telomeric sequences. …”
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    Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions
  5. 225
    “…Telomere length varies considerably among individuals. …”
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    The known genetic loci for telomere length may be involved in the modification of telomeres length after birth
  6. 226
    “…As several cross-sectional studies have shown that psychiatric conditions accelerate aging and shorten telomere length (TL), we explored whether AS affected TL. …”
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    Test anxiety and telomere length: Academic stress in adolescents may not cause rapid telomere erosion
  7. 227
    “…Here we show that, in mammals, telomere dysfunction induces the transcription of telomeric DDRNAs (tDDRNAs) and their longer precursors from both DNA strands. …”
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    DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
  8. 228
    “…BACKGROUND: Telomeric small RNAs related to PIWI-interacting RNAs (piRNAs) have been described in various eukaryotes; however, their role in germline-specific telomere function remains poorly understood. …”
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    Key role of piRNAs in telomeric chromatin maintenance and telomere nuclear positioning in Drosophila germline
  9. 229
    por Tomita, Kazunori
    Publicado 2018
    “…Telomerase, the enzyme that replenishes telomeres, is essential for most eukaryotes to maintain their generations. …”
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    How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis
  10. 230
    “…Telomeres play crucial roles during tumorigenesis, inducing cellular senescence upon telomere shortening and extensive chromosome instability during telomere crisis. …”
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    Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1
  11. 231
    “…Here, we validate in situ RNAscope detection of the telomerase TERT mRNA and couple this assay with our recently described TSQ1 method for in situ detection of telomere elongation. This approach enables detection of TERT expression, telomere length, and telomere elongation within individual cells of the population. …”
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    Preliminary development of an assay for detection of TERT expression, telomere length, and telomere elongation in single cells
  12. 232
    por Aksenova, Anna Y., Mirkin, Sergei M.
    Publicado 2019
    “…Tandem DNA repeats derived from the ancestral (TTAGGG)n run were first detected at chromosome ends of the majority of living organisms, hence the name telomeric DNA repeats. Subsequently, it has become clear that telomeric motifs are also present within chromosomes, and they were suitably called interstitial telomeric sequences (ITSs). …”
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    At the Beginning of the End and in the Middle of the Beginning: Structure and Maintenance of Telomeric DNA Repeats and Interstitial Telomeric Sequences
  13. 233
    “…RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclear. …”
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    Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis
  14. 234
    por Wood, Emma M., Young, Andrew J.
    Publicado 2019
    “…Attempts to understand the causes of variation in senescence trajectories would benefit greatly from biomarkers that reflect the progressive declines in somatic integrity (SI) that lead to senescence. While telomere length has attracted considerable interest in this regard, sources of variation in telomere length potentially unrelated to declines in SI could, in some contexts, leave telomere attrition rates a more effective biomarker than telomere length alone. …”
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    Telomere attrition predicts reduced survival in a wild social bird, but short telomeres do not
  15. 235
    por Mitra, Jaba, Ha, Taekjip
    Publicado 2019
    “…A human telomere ends in a single-stranded 3′ tail, composed of repeats of T(2)AG(3). …”
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    Streamlining effects of extra telomeric repeat on telomeric DNA folding revealed by fluorescence-force spectroscopy
  16. 236
    “…BACKGROUND: A large number of studies have suggested a correlation between the status of telomeres and disease risk. High-throughput quantitative fluorescence in situ hybridization (HT Q-FISH) is a highly accurate telomere measurement technique that can be applied to the study of large cell populations. …”
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    Analytical Validation of Telomere Analysis Technology® for the High-Throughput Analysis of Multiple Telomere-Associated Variables
  17. 237
    “…IDH1 mutations are associated with alpha-thalassemia/mental retardation syndrome X-linked (ATRX) mutations and alternative lengthening of telomeres (ALT), suggesting an interaction between IDH1 and telomeres. …”
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    Alternative lengthening of telomeres is the major telomere maintenance mechanism in astrocytoma with isocitrate dehydrogenase 1 mutation
  18. 238
    “…Telomere anchoring to nuclear envelope (NE) is a key feature of nuclear genome architecture. …”
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    Nuclear envelope attachment of telomeres limits TERRA and telomeric rearrangements in quiescent fission yeast cells
  19. 239
    “…Telomeres consist of TTAGGG repeats bound by protein complexes that serve to protect the natural end of linear chromosomes. …”
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    Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres
  20. 240
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    Correction: Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends
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