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  1. 2401
    “…Molecular analyses were performed for: telomere length (TL); global methylation; and the expression of genes in molecular pathways associated with colorectal tumourigenesis. …”
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    Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel
  2. 2402
    “…We used mass spectrometry-based interactomics to determine the composition of telomere protein complexes in T. brucei BSF and PCF stages to learn more about the structure and functions of telomeres in trypanosomes. …”
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    TelAP1 links telomere complexes with developmental expression site silencing in African trypanosomes
  3. 2403
    por Mekhail, Karim
    Publicado 2018
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    Corrigendum: Defining the Damaged DNA Mobility Paradox as Revealed by the Study of Telomeres, DSBs, Microtubules and Motors
  4. 2404
    “…Whether telomere structure integrity is related to radiosensitivity is not well investigated thus far. …”
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    Tumor Cell–Accelerated Senescence Is Associated With DNA-PKcs Status and Telomere Dysfunction Induced by Radiation
  5. 2405
    “…The identification of telomerase-negative HAATI (heterochromatin amplification-mediated and telomerase-independent) cells, in which telomeres are superseded by nontelomeric heterochromatin tracts, challenged the idea that canonical telomeres are essential for chromosome linearity and raised crucial questions as to how such tracts translocate to eroding chromosome ends and confer end protection. …”
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    RNAi drives nonreciprocal translocations at eroding chromosome ends to establish telomere-free linear chromosomes
  6. 2406
    “…In somatic cells, telomeres contain simple, tandemly repeated G-rich sequences that frequently are reduced by 50 to 200 base pairs at each cell division. …”
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    Significant SNPs Related to Telomere Length and Hepatocellular Carcinoma Risk in Chronic Hepatitis B Carriers
  7. 2407
    “…Linear regression analysis was used to assess relationships among health-related characteristics, cellular aging (measured by leukocyte telomere length; LTL), cART, and BMD of WLWH. WLWH (n = 73; mean age 43 ± 9 years) had lower BMD Z-scores at the lumbar spine (LS) (mean difference = −0.39, p < 0.001) and total hip (TH) (−0.29, p = 0.012) relative to controls (n = 290). …”
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    Premature Spinal Bone Loss in Women Living with HIV is Associated with Shorter Leukocyte Telomere Length
  8. 2408
    “…[Image: see text] Human telomeric G-quadruplex DNA stabilization has emerged as an exciting novel approach for anticancer drug development. …”
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    Naphthalenediimide-Linked Bisbenzimidazole Derivatives as Telomeric G-Quadruplex-Stabilizing Ligands with Improved Anticancer Activity
  9. 2409
    “…Since regulation of telomere length (TL) is one mechanism governing cellular proliferation, TL is a useful surrogate marker for cell replicative potential. …”
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    Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5–12 Weeks of Gestation
  10. 2410
    “…Coats plus (CP) is a rare autosomal recessive disorder caused by mutations in CTC1, a component of the CST (CTC1, STN1, and TEN1) complex important for telomere length maintenance. The molecular basis of how CP mutations impact upon telomere length remains unclear. …”
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    CTC1‐STN1 coordinates G‐ and C‐strand synthesis to regulate telomere length
  11. 2411
    por Manning, Erin L., Van Zant, Gary
    Publicado 2001
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    Role of Telomerase in Maintaining Hematopoietic Stem Cell Telomere Length during Replicative Stress and Aging
  12. 2412
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    Introduction of Telomerase to Ataxia Teleangiectasia Cells Can Extend Shortend Telomere and Bypass Replicative Senescence
  13. 2413
    “…BACKGROUND: Lumbar spinal stenosis (LSS) is a common cause of low back pain with degenerative spinal change in older adults. Telomeres are repetitive nucleoprotein DNA sequences of TTAGGG at the ends of chromosomes. …”
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    Relative telomere length and oxidative DNA damage in hypertrophic ligamentum flavum of lumbar spinal stenosis
  14. 2414
    “…BACKGROUND: The telomere biology disorders (TBDs) include a range of multisystem diseases characterized by mucocutaneous symptoms and bone marrow failure. …”
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    Diagnostics of rare disorders: whole-exome sequencing deciphering locus heterogeneity in telomere biology disorders
  15. 2415
    “…Telomeres protect the ends of eukaryotic chromosomes and are essential for cell viability. …”
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    Evolutionary rates of mammalian telomere-stability genes correlate with karyotype features and female germline expression
  16. 2416
    “…RESULTS: Although there was no significant effect of traffic noise exposure at early (pre-fledging) stages of offspring telomere length or loss rate, traffic noise exposure accelerated telomere loss in older (post-fledging) juveniles. …”
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    Timing matters: traffic noise accelerates telomere loss rate differently across developmental stages
  17. 2417
    “…The present study assessed the cytotoxicity of sodium meta-arsenite (SMA) on telomere shortening and cellular apoptosis in human A-549, MDA-MB-231 and U87-MG cancer cell lines. …”
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    Induction of telomere shortening and cellular apoptosis by sodium meta-arsenite in human cancer cell lines
  18. 2418
    “…Telomeres are transcribed giving rise to telomeric repeat-containing RNAs, called TERRA. …”
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    Live-cell imaging reveals the dynamics and function of single-telomere TERRA molecules in cancer cells
  19. 2419
    “…Telomeric DNA has been intensely investigated for its role in chromosome protection, aging, cell death, and disease. …”
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    Addition of Bases to the 5'-end of Human Telomeric DNA: Influences on Thermal Stability and Energetics of Unfolding
  20. 2420
    “…Meiotic chromosomes undergo rapid prophase movements, which are thought to facilitate the formation of inter-homologue recombination intermediates that underlie synapsis, crossing over and segregation. The meiotic telomere complex (MAJIN, TERB1, TERB2) tethers telomere ends to the nuclear envelope and transmits cytoskeletal forces via the LINC complex to drive these rapid movements. …”
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    Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1
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