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  1. 2421
    “…Telomeric crisis is the final replicative barrier to cell immortalisation; it is characterised by genome instability and cell death and is triggered when telomeres become critically short and are subjected to fusion. …”
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    PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation
  2. 2422
    “…Additionally, we detected linear telomere loss with age, however a random regression analysis did not confirm significant heterogeneity in TL of first breeders and telomere shortening rates in further life. …”
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    Sex-specific effects of parasites on telomere dynamics in a short-lived passerine—the blue tit
  3. 2423
    “…One of these ligands, 5b, stabilizes telomeric G4 preferentially over the G4-forming DNA sequences of c-kit and K-ras, due to the interaction of its piperazinylalkyl side chain with the groove of telomeric G4.…”
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    Synthesis and Telomeric G-Quadruplex-Stabilizing Ability of Macrocyclic Hexaoxazoles Bearing Three Side Chains
  4. 2424
    por Eisenberg, Dan T. A.
    Publicado 2019
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    Paternal age at conception effects on offspring telomere length across species—What explains the variability?
  5. 2425
    “…Differential retention of Hop1 requires the disassemblase Pch2/TRIP13, which preferentially removes Hop1 from telomere-distant sequences, and is modulated by the histone deacetylase Sir2 and the nucleoporin Nup2. …”
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    Persistent DNA-break potential near telomeres increases initiation of meiotic recombination on short chromosomes
  6. 2426
    “…Background: Epidemiological studies observing inconsistent associations of telomere length (TL) with ischemic stroke (IS) are susceptible to bias according to reverse causation and residual confounding. …”
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    No Causal Effect of Telomere Length on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
  7. 2427
    “…BACKGROUND: Evidence regarding the correlation between lipoproteins and telomere length in US adults is limited. We aimed to investigate whether lipoproteins was associated with telomere length using US National Health and Nutrition Examination Survey (NHANES) database. …”
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    Association between lipoproteins and telomere length in US adults: data from the NHANES 1999–2002
  8. 2428
    “…RESULTS: For this study we compared DFC cell lines that became senescent at different rates (DFC_F: strong senescent phenotype; DFC_S: weak senescent phenotype). The telomeres of DFC_F were shorter than those of the telomeres of DFC_S prior senescence. …”
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    Short telomeres correlate with a strong induction of cellular senescence in human dental follicle cells
  9. 2429
    “…Subjects with GGO lesions had a higher percentage of lymphocytes with shorter telomeres (Q‐FISH, P = 0.003). Furthermore, relative telomere length was also reduced among the GGO cases (qPCR, P < 0.05). …”
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    Peripheral blood telomere alterations in ground glass opacity (GGO) lesions may suggest malignancy
  10. 2430
    “…Telomeres contain TTAGGG (T; Thymine, A; Adenine and G; Guanine) repetitive sequences and are placed at the end of human chromosomes. …”
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    Serum Level of Total Lipids and Telomere Length in the Male Population: A Cross-Sectional Study
  11. 2431
    “…Here, specificity is increased by targeting both G-quadruplex and its flanking duplex DNA in a naturally occurring dsDNA–ssDNA telomere interface using polyamide (PA) and pyridostatin (PDS) conjugates (PA-PDS). …”
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    Submolecular dissection reveals strong and specific binding of polyamide–pyridostatin conjugates to human telomere interface
  12. 2432
    “…Here, we show that the simultaneous suppression of hnRNP A1 and hnRNP A2 resulted in dysfunctional telomeres and induced DNA damage responses in cancer cells. …”
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    Heterogeneous Nuclear Ribonucleoproteins A1 and A2 Function in Telomerase-Dependent Maintenance of Telomeres
  13. 2433
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    Identification of patient-derived glioblastoma stem cell (GSC) lines with the alternative lengthening of telomeres phenotype
  14. 2434
    “…The comparison between different time points in patients with cytogenetic changes showed that in the CD34+ MDS cells, there was a significant decrease in the total number of telomeric signals, the average intensity of signals and the total intensity of telomeres. …”
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    3D Telomere Structure Analysis to Detect Genomic Instability and Cytogenetic Evolution in Myelodysplastic Syndromes
  15. 2435
    “…The influence of smoking exposure on telomere length with a focus on the impact of race has rarely been discussed. …”
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    Associations of smoking indicators and cotinine levels with telomere length: National Health and Nutrition Examination Survey
  16. 2436
    “…These pathways are particularly pertinent at telomeres. Cancer cells that use Alternative Lengthening of Telomeres (ALT) display heightened levels of telomere-specific replication stress, and co-opt stalled replication forks as substrates for break-induced telomere synthesis. …”
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    The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)
  17. 2437
    “…Telomeres are repeated, non-coding deoxyribonucleic acid (DNA) sequences at the end of chromosomes. …”
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    Adverse Childhood Experiences and Telomere Length a Look Into the Heterogeneity of Findings—A Narrative Review
  18. 2438
    “…Genetic factors underlying leukocyte telomere length (LTL) may provide insights into telomere homeostasis, with direct links to disease susceptibility. …”
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    Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies
  19. 2439
    “…Telomere length (TL) is associated with cardiovascular disease (CVD) and cancer. …”
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    Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients
  20. 2440
    “…Telomere length maintenance is essential for cell proliferation, which is particularly prominent in cancer. …”
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    Telomere Maintenance-Associated PML Is a Potential Specific Therapeutic Target of Human Colorectal Cancer
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