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  1. 2441
    “…Smoking is associated with shorter leucocyte telomere length (LTL), a biomarker of increased morbidity and reduced longevity. …”
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    Smoking does not accelerate leucocyte telomere attrition: a meta-analysis of 18 longitudinal cohorts
  2. 2442
    “…Telomeres and telomerase play important roles in maintaining chromosome integrity and genomic stability. …”
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    Association Between Leukocyte Telomere Length and Colorectal Cancer Risk in the Singapore Chinese Health Study
  3. 2443
    por Shin, Yun-A
    Publicado 2019
    “…Obesity is known to continuously increase systemic inflammation and oxidative stress, leading to shorter telomere length. However, research regarding the correlation between physical activity, exercise, obesity, and telomere length is not consistent. …”
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    How Does Obesity and Physical Activity Affect Aging?: Focused on Telomere as a Biomarker of Aging
  4. 2444
    “…Biallelic PARN mutations were associated with Høyeraal–Hreidarsson (HH) syndrome, a rare telomere biology disorder that, because of its severity, is likely not exclusively due to hTR down‐regulation. …”
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    Impaired telomere integrity and rRNA biogenesis in PARN‐deficient patients and knock‐out models
  5. 2445
    “…These defects were suppressed by removal of telomere DNA and by deletion of the telomere-binding protein Taz1. …”
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    Telomere DNA length-dependent regulation of DNA replication timing at internal late replication origins
  6. 2446
    “…OBJECTIVES: To (1) describe the epidemiology of child and adult telomere length, and (2) investigate parent–child telomere length concordance. …”
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    Telomere length: population epidemiology and concordance in Australian children aged 11–12 years and their parents
  7. 2447
    “…Telomeres located at the ends of linear chromosomes play important roles in the maintenance of life. …”
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    Casein kinase 2 regulates telomere protein complex formation through Rap1 phosphorylation
  8. 2448
    “…Telomere length (TL) is a prognostic indicator in Caucasian chronic lymphocytic leukemia (CLL), but its significance in Asian CLL remains unknown. …”
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    Telomere length and its correlation with gene mutations in chronic lymphocytic leukemia in a Korean population
  9. 2449
    “…Simultaneously, a secondary mitotic death pathway is engaged through non-canonical telomere deprotection, regulated by TRF2, Aurora B and ATM. …”
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    Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection
  10. 2450
    “…BRCA1/2 are tumor suppressor genes controlling genomic stability also at telomeric and subtelomeric loci. Their mutation confers a predisposition to different human cancers but also sensitivity to antitumor drugs including poly(ADP-ribose) polymerase (PARP) inhibitors and G-quadruplex stabilizers. …”
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    BRCA2 Deletion Induces Alternative Lengthening of Telomeres in Telomerase Positive Colon Cancer Cells
  11. 2451
    “…BACKGROUND: Telomere length (TL) is a marker of biological aging and is inversely related to aging-related diseases. …”
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    Prenatal Exposure to Phthalates and Newborn Telomere Length: A Birth Cohort Study in Wuhan, China
  12. 2452
    por Tucker, Larry A.
    Publicado 2019
    “…The quantitative polymerase chain reaction method was used to measure leukocyte telomere length. Results showed that milk consumption frequency was not related to telomere length; however, there was a strong association between milk fat intake and telomere length. …”
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    Milk Fat Intake and Telomere Length in U.S. Women and Men: The Role of the Milk Fat Fraction
  13. 2453
    “…Recently, we reported that telomere dysfunction induces the transcription of telomeric non-coding RNAs (tncRNAs) which control the DNA damage response (DDR) at dysfunctional telomeres. …”
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    Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
  14. 2454
    “…Increasing evidence shows that telomere length shortening is associated with the risk for Alzheimer’s disease (AD), pointing to a potential modifiable target for prevention. …”
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    Exploring the Causal Pathway From Telomere Length to Alzheimer’s Disease: An Update Mendelian Randomization Study
  15. 2455
    “…Deregulated telomere length is a causative factor in many physiological and pathological processes, including aging and cancer. …”
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    Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence
  16. 2456
    “…RATIONALE: A subset of patients with idiopathic pulmonary fibrosis (IPF) contains short leukocyte telomeres or telomere related mutations. We previously showed that alveolar type 2 cells have short telomeres in fibrotic lesions. …”
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    From organ to cell: Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis
  17. 2457
    por Lemkul, Justin A
    Publicado 2020
    “…Here, we performed molecular dynamics simulations to study two bimolecular GQs, a telomeric DNA GQ and the analogous telomeric repeat-containing RNA (TERRA) GQ. …”
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    Same fold, different properties: polarizable molecular dynamics simulations of telomeric and TERRA G-quadruplexes
  18. 2458
    “…[Image: see text] Replicative senescence, which is caused by telomere shortening from the end replication problem, is considered one of the tumor-suppressor mechanisms in eukaryotes. …”
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    Ginger Extract Promotes Telomere Shortening and Cellular Senescence in A549 Lung Cancer Cells
  19. 2459
    “…Herein, this study aimed to investigate whether telomere length, a biological indicator of age-related diseases, is associated with ATDILI outcomes and could serve as an early ATDILI biomarker. …”
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    Leukocyte telomere length as a diagnostic biomarker for anti-tuberculosis drug-induced liver injury
  20. 2460
    “…Telomere length attrition has been implicated in various complex disorders including Type 2 Diabetes (T2D). …”
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    Telomere Maintenance Genes are associated with Type 2 Diabetes Susceptibility in Northwest Indian Population Group
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