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  1. 2461
    “…BACKGROUND: Small vessel vasculitis (SVV) is a group of systemic autoimmune diseases that are mediated by neutrophil extracellular traps (NETs) in response to cathelicidin LL37, an aging molecular marker, which could be induced by telomere dysfunction. Therefore, in this study, we evaluated the hypothesis that telomere dysfunction in neutrophils may promote SVV via an LL37-NETs-dependent mechanism. …”
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    Telomere dysfunction promotes small vessel vasculitis via the LL37-NETs-dependent mechanism
  2. 2462
    “…The precise relationship between epigenetic alterations and telomere dysfunction is still an extant question. Previously, we showed that eroded telomeres lead to differentiation instability in murine embryonic stem cells (mESCs) via DNA hypomethylation at pluripotency-factor promoters. …”
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    Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment
  3. 2463
    por Ghosh, Meenakshi, Singh, Mahavir
    Publicado 2020
    “…The telomere repeats containing RNA (TERRA) is transcribed from the C-rich strand of telomere DNA and comprises of UUAGGG nucleotides repeats in humans. …”
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    Structure specific recognition of telomeric repeats containing RNA by the RGG-box of hnRNPA1
  4. 2464
    “…In budding yeast, Cdc13, Stn1, and Ten1 form the telomere-binding heterotrimer CST complex. Here we investigate the role of Cdc13/CST in maintaining genome stability by using a Chr VII disome system that can generate recombinants, chromosome loss, and enigmatic unstable chromosomes. …”
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    Loss of Cdc13 causes genome instability by a deficiency in replication-dependent telomere capping
  5. 2465
    “…In the present study, we analyzed the karyotype of 11 species of Amazonian didelphids, comparing the distribution of the heterochromatin with that of the telomeric signals, and found that, in six species, the ITS coincided with the blocks of heterochromatin. …”
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    Comparison of the heterochromatin and telomeric sequences distribuition in chromosomes of 11 species of Amazonian marsupials (Didelphimorphia; Didelphidae)
  6. 2466
    “…We show that the use of alemtuzumab in lung transplant recipients with short telomeres is safe, though is associated with an increased incidence of neutropenia, thrombocytopenia and anemia requiring packed red blood cell transfusions. …”
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    Alemtuzumab as a Therapy for Chronic Lung Allograft Dysfunction in Lung Transplant Recipients With Short Telomeres
  7. 2467
    por Ingles, Emory D., Deakin, Janine E.
    Publicado 2020
    “…Using long term cell culture, we observed homogenization of telomere length over time. We predict a similar homogenization of telomere lengths occurred in DFT1, and that DFT2 is unlikely to undergo further substantial rearrangements due to maintained telomere length.…”
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    Comparative Cytogenetic Mapping and Telomere Analysis Provide Evolutionary Predictions for Devil Facial Tumour 2
  8. 2468
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    Correction to: Association among dispositional mindfulness, self-compassion, and leukocyte telomere length in Chinese adults
  9. 2469
    “…Approximately 90% of human tumors use telomerase to synthesize de novo telomere repeats and obtain telomere-dependent cellular immortality. …”
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    The Role of Alternative RNA Splicing in the Regulation of hTERT, Telomerase, and Telomeres: Implications for Cancer Therapeutics
  10. 2470
    por Shubin, Calla B, Greider, Carol W
    Publicado 2020
    “…To examine the established link between DNA replication and telomere length, we tested whether firing of telomeric origins would cause telomere lengthening. …”
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    The role of Rif1 in telomere length regulation is separable from its role in origin firing
  11. 2471
    “…Changes of telomere length with age were assessed in diploid and triploid rainbow trout (Oncorhynchus mykiss) females in the cross-sectional study using Q-FISH technique. …”
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    Telomere Dynamics in the Diploid and Triploid Rainbow Trout (Oncorhynchus mykiss) Assessed by Q-FISH Analysis
  12. 2472
    “…A number of molecular markers for biological aging have been identified, including telomere length (TL). Excessive telomere shortening is an index of senescence, causes genomic instability and is associated with a higher risk of age‐related diseases. …”
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    Preconception telomere length as a novel maternal biomarker to assess the risk of spina bifida in the offspring
  13. 2473
    por Sharma, Rohit, Martins, Natália
    Publicado 2020
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    Telomeres, DNA Damage and Ageing: Potential Leads from Ayurvedic Rasayana (Anti-Ageing) Drugs
  14. 2474
    “…Many studies indicate that reduced leukocyte telomere length (LTL) is involved in the EH pathogenesis, however, the direct analysis of arterial telomere length (ATL) from EH patients and normotensive individuals did not show a difference. …”
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    Shorter Leukocyte Telomere Length coupled with lower expression of Telomerase Genes in patients with Essential Hypertension
  15. 2475
    por Lee, Kyung Hyun, Kimmel, Marek
    Publicado 2020
    “…Under the normal physiological condition, telomeres shorten with each cell division, and cells use the telomere lengths to sense the number of divisions. …”
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    Analysis of two mechanisms of telomere maintenance based on the theory of g-Networks and stochastic automata networks
  16. 2476
    “…Telomeric DNA, whose length homeostasis is closely correlated with immortality of cancer cells, is regarded as a molecular clock for cellular lifespan. …”
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    Near-infrared-traceable DNA nano-hydrolase: specific eradication of telomeric G-overhang in vivo
  17. 2477
    “…BACKGROUND: Shorter telomere length (TL) has been associated with poor health behaviors, increased risks of chronic diseases and early mortality. …”
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    Effect of plasma polyunsaturated fatty acid levels on leukocyte telomere lengths in the Singaporean Chinese population
  18. 2478
    “…Telomeres are DNA-protein structures at the ends of chromosomes essential in maintaining chromosomal stability. …”
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    Genetically predicted telomere length is associated with clonal somatic copy number alterations in peripheral leukocytes
  19. 2479
    “…Here we show that some T cells (primarily naïve and central memory cells) elongated telomeres by acquiring telomere vesicles from antigen-presenting cells (APCs) independently of telomerase action. …”
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    An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory
  20. 2480
    “…We explored whether measures of telomere length could be used as an alternative approach to age estimation in dugongs given that in other species, telomere length and age are inversely related. …”
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    Age relationships with telomere length, body weight and body length in wild dugong (Dugong dugon)
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