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  1. 2501
    por Aguilar, Miguel, Prieto, Pilar
    Publicado 2021
    “…In plant polyploids, these terminal regions are even more important in terms of homologous chromosome recognition, due to the presence of homoeologs (equivalent chromosomes from related genomes). Although telomeres interaction seems to assist homologous pairing and consequently, the progression of meiosis, other chromosome regions, such as subtelomeres, need to be considered, because the DNA sequence of telomeres is not chromosome-specific. …”
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    Telomeres and Subtelomeres Dynamics in the Context of Early Chromosome Interactions During Meiosis and Their Implications in Plant Breeding
  2. 2502
    “…Alternative Lengthening of Telomeres (ALT) is a Break-Induced Replication (BIR)-based mechanism elongating telomeres in a subset of human cancer cells. …”
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    TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells
  3. 2503
    “…Studies in humans and model systems have established an important role of short telomeres in predisposing to liver fibrosis through pathways that are incompletely understood. …”
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    Fructose Causes Liver Damage, Polyploidy, and Dysplasia in the Setting of Short Telomeres and p53 Loss
  4. 2504
    “…PURPOSE OF REVIEW: Alternative lengthening of telomeres (ALT) is a telomerase-independent mechanism used by some types of malignancies, including pancreatic neuroendocrine tumors, to overcome the issue of telomere shortening, thus supporting tumor growth and cell proliferation. …”
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    Alternative Lengthening of Telomeres (ALT) in Pancreatic Neuroendocrine Tumors: Ready for Prime-Time in Clinical Practice?
  5. 2505
    “…This study aimed to systematically review the association between telomere length (TL) and muscular fitness. In October 2020, an articles search was applied to PubMed, Scopus, and Web of Science. …”
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    A Systematic Review of the Association Between Muscular Fitness and Telomere Length Across the Adult Lifespan
  6. 2506
    por Wang, Chuanle, Songyang, Zhou, Huang, Yan
    Publicado 2021
    “…BACKGROUND: About 10–15% of tumor cells extend telomeres through the alternative lengthening of telomeres (ALT) mechanism, which is a recombination-dependent replication pathway. …”
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    TRIM28 inhibits alternative lengthening of telomere phenotypes by protecting SETDB1 from degradation
  7. 2507
    “…Finally, using super-resolution microscopy in the female germline, we show that homologous chromosomes remain associated at telomere domains in the absence of chiasma and after breakdown and modification to the synaptonemal complex in pachytene. …”
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    Oligopaint DNA FISH reveals telomere-based meiotic pairing dynamics in the silkworm, Bombyx mori
  8. 2508
    “…Similar to the human shelterin, fission yeast shelterin is composed of telomeric double- and single-stranded DNA-binding proteins, Taz1 and Pot1, respectively, bridged by Rap1, Poz1 and Tpz1. …”
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    The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis
  9. 2509
    por Li, Bibo, Zhao, Yanxiang
    Publicado 2021
    “…Here we will focus on T. brucei TRF and RAP1, two telomere proteins with unique nucleic acid binding activities, and summarize their functions in telomere integrity and stability, VSG switching, and monoallelic VSG expression. …”
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    Regulation of Antigenic Variation by Trypanosoma brucei Telomere Proteins Depends on Their Unique DNA Binding Activities
  10. 2510
    “…Telomere maintenance is essential to preserve genomic stability and involves telomere-specific proteins, DNA replication and repair proteins. …”
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    Increase in lamin B1 promotes telomere instability by disrupting the shelterin complex in human cells
  11. 2511
    “…This endeavor is especially challenging for the telomere length (TL) quantitative-PCR (qPCR) assay, where amplification efficiency can vary between reactions targeting telomeric repeats (T) and those targeting a single-copy gene (S) to calculate TL as the T/S ratio. …”
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    Impact of Amplification Efficiency Approaches on Telomere Length Measurement via Quantitative-Polymerase Chain Reaction
  12. 2512
    por Hao, Lu, Chen, Qiuyan, Chen, Xi, Zhou, Qing
    Publicado 2021
    “…However, it remains unknown whether elevated circulating bilirubin is associated with longer telomere length. The aim of this cross-sectional study was to examine the association between total bilirubin concentration and telomere length. …”
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    Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination Survey
  13. 2513
    “…Remarkably, we demonstrate that some copies of acqHHV-6B in saliva from healthy adults gained a telomere, indicative of integration and latency, and that the frequency of viral genome excision from telomeres in iciHHV-6B carriers is surprisingly high and varies between tissues. …”
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    Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals
  14. 2514
    “…Familial pulmonary fibrosis (FPF) is a monogenic disease most commonly involving telomere- (TERT) or surfactant- (SFTP) related mutations. …”
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    The Extent of Inflammatory Cell Infiltrate and Fibrosis in Lungs of Telomere- and Surfactant-Related Familial Pulmonary Fibrosis
  15. 2515
    “…BACKGROUND: Telomerase-negative cells have limited proliferation potential. In these cells, telomeres shorten until they reach a critical length and induce a permanently arrested state. …”
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    Telomere shortening causes distinct cell division regimes during replicative senescence in Saccharomyces cerevisiae
  16. 2516
    “…Telomeres are protective structures at the ends of linear chromosomes. …”
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    Genetic, Environmental and Lifestyle Determinants of Accelerated Telomere Attrition as Contributors to Risk and Severity of Multiple Sclerosis
  17. 2517
    “…As indicators for aging, we measured ovarian mitochondrial size and telomere length in peripheral leukocytes. We report in this study that in both breeds the distance between capillaries became smaller with increasing age and that the mean telomere length decreased with increasing age. …”
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    Influence of Age and Breed on Bovine Ovarian Capillary Blood Supply, Ovarian Mitochondria and Telomere Length
  18. 2518
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    Clinical and molecular correlates from a predominantly adult cohort of patients with short telomere lengths
  19. 2519
    por Wada, Ryohei, Yoshida, Wataru
    Publicado 2021
    “…In this study, the effects of m(6)dA modification on the thermal stability of four distinct telomeric G-quadruplex (G4) structures were investigated. …”
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    Thermal Stability Changes in Telomeric G-Quadruplex Structures Due to N(6)-Methyladenine Modification
  20. 2520
    por Xiong, Fusheng, Frasch, Wayne D
    Publicado 2021
    “…ΩqPCR determines absolute telomere length in kb units from single cells. Accuracy and precision of ΩqPCR were assessed using 800 bp and 1600 bp synthetic telomeres inserted into plasmids, which were measured to be 819 ± 19.6 and 1590 ± 42.3 bp, respectively. …”
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    ΩqPCR measures telomere length from single-cells in base pair units
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