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Mostrando 241 - 260 Resultados de 8,819 Para Buscar 'Telonero~', tiempo de consulta: 5.17s Limitar resultados
  1. 241
    “…These cancers are characterized by instability at short tandem repeats (STRs) and in telomeric DNA. We have investigated telomere length in saliva DNA from LS and control families, using single telomere analysis at XpYp and 12q and by qPCR to measure total telomeric DNA. …”
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    Telomere Instability in Lynch Syndrome Families Leads to Some Shorter Telomeres in MSH2+/- Carriers
  2. 242
    “…Telomeres are repetitive non-coding nucleotide sequences (TTAGGGn) capping the ends of chromosomes. …”
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    Imaging assay to probe the role of telomere length shortening on telomere-gene interactions in single cells
  3. 243
    por Kent, Thomas, Clynes, David
    Publicado 2021
    “…Extensive research over the past 20 years has shown that the key molecular event underpinning a subset of cancers involves the deregulated repair of DNA double-strand breaks (DSBs) at telomeres, which in turn leads to telomere lengthening and the potential for replicative immortality. …”
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    Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair
  4. 244
    por Hwang, Moo Gak, Cho, Myeon Haeng
    Publicado 2007
    “…Telomeres are specific protein–DNA complexes that protect the ends of eukaryotic chromosomes from fusion and degradation and are maintained by a specialized mechanism exerted by telomerase and telomere-binding proteins (TBPs), which are evolutionarily conserved. …”
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    Arabidopsis thaliana telomeric DNA-binding protein 1 is required for telomere length homeostasis and its Myb-extension domain stabilizes plant telomeric DNA binding
  5. 245
    “…Here, we de novo assembled and annotated a telomere-to-telomere, gap-free genome of F. vesca ‘Hawaii 4’, with all seven chromosomes assembled into single contigs, providing the highest completeness and assembly quality to date. …”
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    The telomere-to-telomere genome of Fragaria vesca reveals the genomic evolution of Fragaria and the origin of cultivated octoploid strawberry
  6. 246
    “…The majority of attention has been paid to the solution of complex chromosome structures and highly repetitive sequences, along with the emergence of a new ‘telomere-to-telomere (T2T) assembly’ era. However, the bioinformatic tools for the automatic construction and/or characterization of T2T genome are limited. …”
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    quarTeT: a telomere-to-telomere toolkit for gap-free genome assembly and centromeric repeat identification
  7. 247
    “…Eleven pseudo-chromosomes had telomere repeats at both ends, and four had telomere repeats at a single end. …”
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    A telomere-to-telomere reference genome provides genetic insight into the pentacyclic triterpenoid biosynthesis in Chaenomeles speciosa
  8. 248
    “…The telomere resolvase, TelA, forms the hairpin telomeres of the linear chromosome of Agrobacterium tumefaciens in a process referred to as telomere resolution. …”
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    The telomere resolvase, TelA, utilizes an underwound pre-cleavage intermediate to promote hairpin telomere formation
  9. 249
    “…We found that many unmapped reads in GRCh38 originate from telomeres and centromeres that are gaps in GRCh38. …”
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    Localizing unmapped sequences with families to validate the Telomere-to-Telomere assembly and identify new hotspots for genetic diversity
  10. 250
    “…Some human cancers maintain their telomeres using the alternative lengthening of telomeres (ALT) mechanism; a process thought to involve recombination. …”
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    Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination
  11. 251
    “…MDV and HHV-6, among other herpesviruses, harbor telomeric repeats (TMRs) identical to host telomeres at either end of their linear genomes. …”
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    Herpesvirus telomeric repeats facilitate genomic integration into host telomeres and mobilization of viral DNA during reactivation
  12. 252
    “…While telomere repeat-containing non-coding RNA has been identified in a variety of eukaryotes, its biological role is not yet clear. …”
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    Non-coding telomeric and subtelomeric transcripts are differentially regulated by telomeric and heterochromatin assembly factors in fission yeast
  13. 253
    “…Telomeres, specialised structures that protect chromosome ends, play a critical role in preserving chromosome integrity. …”
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    Extreme Telomere Length Dimorphism in the Tasmanian Devil and Related Marsupials Suggests Parental Control of Telomere Length
  14. 254
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    Correction: Telomeric Repeats Facilitate CENP-A(Cnp1) Incorporation via Telomere Binding Proteins
  15. 255
    “…Genome-wide systematic screens in yeast have uncovered a large gene network (the telomere length maintenance network or TLM), encompassing more than 400 genes, which acts coordinatively to maintain telomere length. …”
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    Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups
  16. 256
    “…A fraction of cancer cells maintain telomeres through the telomerase-independent, ‘Alternative Lengthening of Telomeres’ (ALT) pathway. …”
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    RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells
  17. 257
    por Cusanelli, Emilio, Chartrand, Pascal
    Publicado 2015
    “…For this reason, telomeres are essential to genome integrity. Chromosome ends are enriched in heterochromatic marks and proper organization of telomeric chromatin is important to telomere stability. …”
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    Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity
  18. 258
    “…POT1(CP) was expressed at normal levels, bound TPP1 and telomeres, and blocked ATR signaling. POT1(CP) was defective in regulating telomerase, leading to telomere elongation rather than the telomere shortening observed in other telomeropathies. …”
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    A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus
  19. 259
    “…Telomeres are capped at the ends of eukaryotic chromosomes and are composed of TTAGGG repeats bound to the shelterin complex. …”
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    An H2A Histone Isotype, H2ac, Associates with Telomere and Maintains Telomere Integrity
  20. 260
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    Corrigendum: DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
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