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Mostrando 301 - 320 Resultados de 8,819 Para Buscar 'Telonero~', tiempo de consulta: 2.96s Limitar resultados
  1. 301
    “…Telomerase, the enzyme that adds telomeric repeats to chromosome ends, is essential for maintaining the overall telomere length. …”
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    Telomerase Activity and Telomere Length in Daphnia
  2. 302
    “…RESULTS: Here we aimed to investigate both telomere structure and function in FRDA cells. Our results confirmed telomere shortening in FRDA patient leukocytes and identified similar telomere shortening in FRDA patient autopsy cerebellar tissues. …”
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    Identification of telomere dysfunction in Friedreich ataxia
  3. 303
    “…The unlimited proliferation of cancer cells requires a mechanism to prevent telomere shortening. Alternative Lengthening of Telomeres (ALT) is an homologous recombination-mediated mechanism of telomere elongation used in tumors, including osteosarcomas, soft tissue sarcoma subtypes, and glial brain tumors. …”
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    ATRX represses alternative lengthening of telomeres
  4. 304
    por de Lange, Titia
    Publicado 2015
    “…About a decade ago, I proposed that t-loops, the lariat structures adopted by many eukaryotic telomeres, could explain how the transition from circular to linear chromosomes was successfully negotiated by early eukaryotes. …”
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    A loopy view of telomere evolution
  5. 305
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    Commentary: The reliability of telomere length measurements
  6. 306
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    Polychlorinated Biphenyls and Cancer: Are Telomeres to Blame?
  7. 307
    “…Fly telomeres are protected by the terminin complex that localizes and functions exclusively at telomeres and by non-terminin proteins that do not serve telomere-specific functions. …”
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    A role for Separase in telomere protection
  8. 308
    por Donati, Benedetta, Valenti, Luca
    Publicado 2016
    “…Telomeres consist of repeat DNA sequences located at the terminal portion of chromosomes that shorten during mitosis, protecting the tips of chromosomes. …”
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    Telomeres, NAFLD and Chronic Liver Disease
  9. 309
    por Rice, Cory, Skordalakes, Emmanuel
    Publicado 2016
    “…Telomeres comprise the ends of eukaryotic chromosomes and are essential for cell proliferation and genome maintenance. …”
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    Structure and function of the telomeric CST complex
  10. 310
    por Marcand, Stéphane
    Publicado 2014
    “…Since a single end-joining event between 2 telomeres generates a circular chromosome or an unstable dicentric chromosome, NHEJ must be prevented from acting on telomeres. …”
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    How do telomeres and NHEJ coexist?
  11. 311
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    Ruxolitinib therapy and telomere length in myelofibrosis
  12. 312
    “…Eukaryotic chromosomal ends are protected by telomeres from fusion, degradation, and unwanted double-strand break repair events. …”
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    Role of the ESCRT Complexes in Telomere Biology
  13. 313
    por Bateson, Melissa, Nettle, Daniel
    Publicado 2016
    “…Longitudinal studies of human leucocyte telomere length often report a percentage of individuals whose telomeres appear to lengthen. …”
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    The telomere lengthening conundrum – it could be biology
  14. 314
    por Claussin, Clémence, Chang, Michael
    Publicado 2015
    “…The ends of linear chromosomes are capped by nucleoprotein structures called telomeres. A dysfunctional telomere may resemble a DNA double-strand break (DSB), which is a severe form of DNA damage. …”
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    The many facets of homologous recombination at telomeres
  15. 315
    “…Tumor cells with metastatic potential may have a high telomerase activity, allowing cells to escape from the inhibition of cell proliferation due to shortened telomeres. Human telomerase primarily consists of two main components: hTERT, a catalytic subunit, and hTR, an RNA template whose sequence is complimentary to the telomeric 5′-dTTAGGG-3′ repeat. …”
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    Treating Cancer by Targeting Telomeres and Telomerase
  16. 316
    “…We define leukocyte telomere length of 5 kb as the ‘telomeric brink’, which denotes a high risk of imminent death. …”
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    Telomeres and the natural lifespan limit in humans
  17. 317
    “…Telomeres are essential nucleoprotein structures at linear chromosomes that maintain genome integrity by protecting chromosome ends from being recognized and processed as damaged DNA. …”
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    Ubiquitination and SUMOylation in Telomere Maintenance and Dysfunction
  18. 318
    “…In order to progress STS's cells must evade the usual cellular proliferative checkpoints, and then activate a telomere maintenance mechanism in order to achieve replicative immortality. …”
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    Telomere maintenance in soft tissue sarcomas
  19. 319
    “…Consequently, such organisms possess telomeres to cap chromosome ends. Telomeres are essentially tandem repeats of any DNA sequence that are present at the ends of chromosomes. …”
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    Telomere Biology—Insights into an Intriguing Phenomenon
  20. 320
    por Victorelli, Stella, Passos, João F.
    Publicado 2017
    “…Telomeres are protective structures present at the ends of linear chromosomes that are important in preventing genome instability. …”
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    Telomeres and Cell Senescence - Size Matters Not
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