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Mostrando 501 - 520 Resultados de 8,819 Para Buscar 'Telonero~', tiempo de consulta: 5.68s Limitar resultados
  1. 501
    “…Five (10%) relatives were also found with these variants, all harboring a pathogenic germline variant in telomere biology genes. TERTp clone selection did not associate with peripheral blood counts, telomere length, and response to danazol treatment. …”
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    Pathogenic TERT promoter variants in telomere diseases
  2. 502
    “…Telomeres are nucleotide tandem repeats located at the tip of eukaryotic chromosomes that maintain genomic integrity. …”
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    Association of nutraceutical supplements with longer telomere length
  3. 503
    “…(1) Background: Telomeres are repetitive DNA sequences located at the extremities of chromosomes that maintain genetic stability. …”
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    Relative Telomere Length and Cardiovascular Risk Factors
  4. 504
    “…In Drosophila biarmipes, telomere-specialized elements have disappeared completely. …”
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    Diversification and collapse of a telomere elongation mechanism
  5. 505
    “…Telomeres are considered as universal anti‐cancer targets, as telomere maintenance is essential to sustain indefinite cancer growth. …”
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    Multiple cancer pathways regulate telomere protection
  6. 506
    “…This disease seems to be associated with several hallmarks of aging, including telomere attrition and cellular senescence. Increasing evidence suggests that abnormalities involving telomeres and their proteome play a significant role in the pathobiology of IPF. …”
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    Telomere Abnormalities in the Pathobiology of Idiopathic Pulmonary Fibrosis
  7. 507
    por Amano, Hisayuki, Sahin, Ergun
    Publicado 2019
    “…A recent study demonstrates that telomere shortening represses sirtuins and increasing sirtuin activity stabilizes telomeres and improves telomere-dependent disease, suggesting that these two pathways are tightly intertwined.…”
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    Telomeres and sirtuins: at the end we meet again
  8. 508
    “…Telomere length (TL) is associated with several aging-related diseases. …”
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    DNA methylation-based estimator of telomere length
  9. 509
    “…OBJECTIVE: We systematically evaluated CNS manifestations in patients with inherited telomere biology disorders (TBDs) to better understand the clinical and biological consequences of germline aberrations in telomere biology. …”
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    CNS manifestations in patients with telomere biology disorders
  10. 510
    “…This review discusses the role of telomeres and telomerase in OA and OP pathologies and focuses on the usability of telomere length (TL) and the rate of telomere shortening as potential disease biomarkers. …”
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    Telomere length and telomerase activity in osteoporosis and osteoarthritis
  11. 511
    por Peska, Vratislav, Garcia, Sònia
    Publicado 2020
    “…Telomeres are basic structures of eukaryote genomes. …”
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    Origin, Diversity, and Evolution of Telomere Sequences in Plants
  12. 512
    “…The main purpose of the review article is to assess the contributions of telomere length and telomerase activity to the cardiac function at different stages of development and clarify their role in cardiac disorders. …”
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    Telomeres and Telomerase in Heart Ontogenesis, Aging and Regeneration
  13. 513
    por Tan, Jun, Lan, Li
    Publicado 2020
    “…Telomeric DNA are TTAGGG tandem repeats, which are susceptible for oxidative DNA damage and hotspot regions for formation of DNA secondary structures such as t-loop, D-loop, G-quadruplexes (G4), and R-loop. …”
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    The DNA secondary structures at telomeres and genome instability
  14. 514
    por Monroy-Jaramillo, Nancy
    Publicado 2017
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    Analyzing leukocyte telomere length in bipolar disorder
  15. 515
    “…For this reason, centromeres and telomeres are parts of each linear chromosome that are necessary for their proper functioning. …”
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    The epigenetic regulation of centromeres and telomeres in plants and animals
  16. 516
    por Seimiya, Hiroyuki
    Publicado 2020
    “…The telomere is the specialized nucleoprotein complex at the end of the chromosome. …”
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    Crossroads of telomere biology and anticancer drug discovery
  17. 517
    “…Persons with HIV demonstrate increased risk for aging-associated complications and have reduced telomere length (TL) compared with age-matched persons without HIV. …”
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    Relationship of Telomere Length to Fat Redistribution in HIV
  18. 518
    por Perona, Rosario
    Publicado 2020
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    The Different Roads to Maintain Telomeres in Cancer Cells
  19. 519
    “…Telomere crisis contributes to cancer genome evolution, yet only a subset of cancers display breakage-fusion-bridge (BFB) cycles and chromothripsis, hallmarks of experimental telomere crisis identified in previous studies. …”
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    Structural variant evolution after telomere crisis
  20. 520
    “…This effect was most pronounced at the chain termini, which could promote telomere extension by telomerase. We conclude that folding frustration is an important and largely overlooked factor controlling the structure of telomeric DNA.…”
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    Frustrated folding of guanine quadruplexes in telomeric DNA
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