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581por Lee, Junyeop, Lee, Jina, Sohn, Eric J., Taglialatela, Angelo, O’Sullivan, Roderick J., Ciccia, Alberto, Min, Jaewon“…Alternative Lengthening of Telomeres (ALT) is a telomere maintenance mechanism mediated by break-induced replication (BIR), evident in approximately 15% of human cancers. …”
Publicado 2023
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582por Kreilmeier-Berger, Theresa, Aupperle-Lellbach, Heike, Reifinger, Martin, Hörstke, Nicolai Valentin, Holzmann, Klaus, Kleiter, Miriam“…SIMPLE SUMMARY: Knowledge of telomere maintenance mechanisms (TMMs) in different tumor types is crucial for the development of TMM-specific diagnostics and therapies. …”
Publicado 2023
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583por Sullivan, Daniel I., Bello, Fiona M., Silva, Agustin Gil, Redding, Kevin M., Giordano, Luca, Hinchie, Angela M., Loughridge, Kelly E., Mora, Ana L., Königshoff, Melanie, Kaufman, Brett A., Jurczak, Michael J., Alder, Jonathan K.“…Conversely, we examined the consequences of dysfunctional telomere‐driven cellular senescence on mitochondrial biogenesis and function. …”
Publicado 2023
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584“…RESULTS: After conducting the follow-up analysis, it was observed that 83.3% of the participants in the study exhibited a reduction in telomere length, while 16.7% experienced an increase in telomere length. …”
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585por Kakridonis, Fotios, Pneumatikos, Spyros G., Vakonaki, Elena, Berdiaki, Aikaterini, Tzatzarakis, Manolis N., Fragkiadaki, Persefoni, Spandidos, Demetrios A., Baliou, Stella, Ioannou, Petros, Hatzidaki, Eleftheria, Nikitovic, Dragana, Tsatsakis, Aristidis, Vasiliadis, Elias“…Telomeres are the ends of chromosomes that protect them from DNA damage. …”
Publicado 2023
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586por Yeung, Suey S.Y., Ma, Suk Ling, Wang, Xingyan, Chen, Yangchao, Tsui, Stephen Kwok Wing, Tang, Nelson Leung Sang, Woo, Jean“…INTRODUCTION: Telomere length (TL) is generally regarded as a biomarker of aging. …”
Publicado 2023
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587“…Telomerase consists of a reverse transcriptase (TERT) and an RNA that contains a template for telomere-repeat extension. Telomerase is required to prevent telomere erosion and its activity or lack thereof is important for tumorigenesis and ageing. …”
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588
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589“…The histone H2A variant H2AX is phosphorylated in response to DNA double-strand breaks originating from diverse origins, including dysfunctional telomeres. Here, we show that normal mitotic telomere maintenance does not require H2AX. …”
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590por Tabori, U, Wong, V, Ma, J, Shago, M, Alon, N, Rutka, J, Bouffet, E, Bartels, U, Malkin, D, Hawkins, C“…There was no correlation between telomere length and hTERT expression or survival. Surprisingly, prior radiation or chemotherapy neither induced sustained DNA damage nor affected telomere maintenance in recurrent tumours. …”
Publicado 2008
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591“…Est1p telomere association was low in all four strains. Wild type levels of Est2p telomere binding in late S/G2 phase was Est1p-dependent and required that Est1p be both telomere-bound and associated with a stem-bulge region in TLC1 RNA. …”
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592por Hertz-Fowler, Christiane, Figueiredo, Luisa M., Quail, Michael A., Becker, Marion, Jackson, Andrew, Bason, Nathalie, Brooks, Karen, Churcher, Carol, Fahkro, Samah, Goodhead, Ian, Heath, Paul, Kartvelishvili, Magdalena, Mungall, Karen, Harris, David, Hauser, Heidi, Sanders, Mandy, Saunders, David, Seeger, Kathy, Sharp, Sarah, Taylor, Jesse E., Walker, Danielle, White, Brian, Young, Rosanna, Cross, George A. M., Rudenko, Gloria, Barry, J. David, Louis, Edward J., Berriman, Matthew“…One of the best known examples of the use of telomere proximity for adaptive purposes are the bloodstream expression sites (BESs) of the African trypanosome Trypanosoma brucei. …”
Publicado 2008
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593
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594“…Telomeres are nucleoprotein structures located at the linear ends of eukaryotic chromosomes. …”
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595por Adelfalk, Caroline, Janschek, Johannes, Revenkova, Ekaterina, Blei, Cornelia, Liebe, Bodo, Göb, Eva, Alsheimer, Manfred, Benavente, Ricardo, de Boer, Esther, Novak, Ivana, Höög, Christer, Scherthan, Harry, Jessberger, Rolf“…Meiosis-specific mammalian cohesin SMC1β is required for complete sister chromatid cohesion and proper axes/loop structure of axial elements (AEs) and synaptonemal complexes (SCs). During prophase I, telomeres attach to the nuclear envelope (NE), but in Smc1β(−/−) meiocytes, one fifth of their telomeres fail to attach. …”
Publicado 2009
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597por Wang, Zhilong, Rhee, David B., Lu, Jian, Bohr, Christina T., Zhou, Fang, Vallabhaneni, Haritha, de Souza-Pinto, Nadja C., Liu, Yie“…Here, we investigated the impact of oxidative guanine damage and its repair by OGG1 on telomere integrity in mice. The mouse cells were analyzed for telomere integrity by telomere quantitative fluorescence in situ hybridization (telomere–FISH), by chromosome orientation–FISH (CO–FISH), and by indirect immunofluorescence in combination with telomere–FISH and for oxidative base lesions by Fpg-incision/Southern blot assay. …”
Publicado 2010
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598por Diaz de Leon, Alberto, Cronkhite, Jennifer T., Katzenstein, Anna-Luise A., Godwin, J. David, Raghu, Ganesh, Glazer, Craig S., Rosenblatt, Randall L., Girod, Carlos E., Garrity, Edward R., Xing, Chao, Garcia, Christine Kim“…Here we examine the telomere lengths and pulmonary fibrosis phenotype seen in multiple kindreds with heterozygous TERT mutations. …”
Publicado 2010
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599“…Cdc13 is a single stranded telomere binding protein that specifically localizes to the telomere ends of budding yeasts and is essential for cell viability. …”
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600por Anchelin, Monique, Murcia, Laura, Alcaraz-Pérez, Francisca, García-Navarro, Esther M., Cayuela, María L.“…Telomere length and telomerase activity are important factors in the pathobiology of human diseases. …”
Publicado 2011
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