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Mostrando 601 - 620 Resultados de 8,819 Para Buscar 'Telonero~', tiempo de consulta: 3.19s Limitar resultados
  1. 601
    “…INTRODUCTION: Telomere shortening is a cell-intrinsic mechanism that limits cell proliferation by induction of DNA damage responses resulting either in apoptosis or cellular senescence. …”
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    Regeneration of the Exocrine Pancreas Is Delayed in Telomere-Dysfunctional Mice
  2. 602
    “…We examined whether telomere length, which is inherited and known to shorten with age, plays a role in the age-dependent increased incidence of diabetes. …”
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    Short Telomeres Compromise β-Cell Signaling and Survival
  3. 603
    “…The probability of forming proper telomere structures depends on the length of the telomeric DNA tract. …”
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    Genome-Wide Association Study of Relative Telomere Length
  4. 604
    “…Many data pertaining to the accelerated telomere loss in cultured cells derived from Werner syndrome (WS), a representative premature aging syndrome, have been accumulated. …”
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    Accelerated in vivo epidermal telomere loss in Werner syndrome
  5. 605
    “…There is a considerable heterogeneity in blood cell telomere length (TL) for individuals of similar age and recent studies have revealed that TL changes by time are dependent on TL at baseline. …”
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    Blood Cell Telomere Length Is a Dynamic Feature
  6. 606
    por Kimura, Masayuki, Aviv, Abraham
    Publicado 2011
    “…Telomeres play a central role in human cancer, cardiovascular aging and possibly longevity. …”
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    Measurement of telomere DNA content by dot blot analysis
  7. 607
    “…CONTEXT: Obesity in adults is associated with shorter mean leukocyte telomere length (LTL), a marker of biological age that is also associated with age-related conditions including cardiovascular disease and type 2 diabetes. …”
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    Childhood Obesity Is Associated with Shorter Leukocyte Telomere Length
  8. 608
    “…Leukocyte telomere length (TL) is considered a biomarker for biological aging. …”
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    Leukocyte Telomere Length in the Finnish Diabetes Prevention Study
  9. 609
    “…In many organisms, telomere DNA consists of simple sequence repeat tracts that are required to protect the chromosome end. …”
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    Mec1p associates with functionally compromised telomeres
  10. 610
    “…CONTEXT: Whether a healthy lifestyle may be associated with longer telomere length is largely unknown. OBJECTIVES: To examine healthy lifestyle practices, which are primary prevention measures against major age-related chronic diseases, in relation to leukocyte telomere length. …”
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    Healthy Lifestyle and Leukocyte Telomere Length in U.S. Women
  11. 611
    “…A major interest has recently emerged in understanding how telomere shortening, mechanism triggering cell senescence, is linked to organism ageing and life history traits in wild species. …”
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    Telomeres, Age and Reproduction in a Long-Lived Reptile
  12. 612
    “…The unlimited proliferation potential of cancer cells requires the maintenance of their telomeres. This is frequently accomplished by reactivation of telomerase. …”
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    PML body meets telomere: The beginning of an ALTernate ending?
  13. 613
    “…Also, as evidence of unstable telomeres, colocalization of γ-H2AX and telomere signals in interphase cells was observed. …”
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    Genomic Instability and Telomere Fusion of Canine Osteosarcoma Cells
  14. 614
    por Chiodi, Ilaria, Mondello, Chiara
    Publicado 2012
    “…Telomerase canonical activity at telomeres prevents telomere shortening, allowing chromosome stability and cellular proliferation. …”
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    Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria
  15. 615
    “…Leukocyte telomere length (LTL) provides a potential marker of biological age, closely related to the endothelial dysfunction and consequently to the atherosclerotic process. …”
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    Telomere Length Variation in Juvenile Acute Myocardial Infarction
  16. 616
    “…Telomere shortening in somatic tissues largely reflects stem cell replication. …”
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    Telomeres shorten at equivalent rates in somatic tissues of adults
  17. 617
    “…BACKGROUND: Telomeres alteration during carcinogenesis and tumor progression has been described in several cancer types. …”
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    Telomere Length Modulation in Human Astroglial Brain Tumors
  18. 618
    “…As the chromosomal localization of γH2Ax foci plays an important role in determining the molecular mechanism responsible for their formation, we examined the localization of Pb-induced foci with respect to telomeres. Indeed, short or dysfunctional telomeres (uncapped or damaged telomeres) may be recognized as DSB by the DNA repair machinery, leading to “telomere-Induced Foci” (TIFs). …”
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    Lead Exposure Induces Telomere Instability in Human Cells
  19. 619
    “…Therefore, here we reviewed studies focused on the assessment of telomeric length in brain tumours with the aim to emphasized those findings indicating a potential clinical role of telomeres in GBM. …”
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    Potential Clinical Role of Telomere Length in Human Glioblastoma
  20. 620
    “…Telomere lengths vary among different porcine iPS cell lines, some with telomere elongation and maintenance, and others telomere shortening. …”
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    Telomere Reprogramming and Maintenance in Porcine iPS Cells
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