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Mostrando 621 - 640 Resultados de 8,819 Para Buscar 'Telonero~', tiempo de consulta: 3.28s Limitar resultados
  1. 621
    “…Despite the importance of this enzyme, our understanding of the mechanisms that regulate its activity and establish telomere length homeostasis in mammalian cells is incomplete, in part because the perfect repetitive nature of telomeric sequence hampers in situ detection of telomere elongation patterns. …”
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    In situ visualization of telomere elongation patterns in human cells
  2. 622
    “…Here, we propose that the inhibition of the MEN is specifically required when telomeres are damaged but it is not necessary to face all types of chromosomal DNA damage, which is in agreement with previous data in mammals suggesting the existence of a putative telomere-specific DNA damage response that inhibits mitotic exit. …”
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    Inhibition of the Mitotic Exit Network in Response to Damaged Telomeres
  3. 623
    “…Chromosome ends, or telomeres, are protected by nucleoprotein caps which avoid their recognition as DSB by the cellular DNA repair machinery. …”
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    Signaling of double strand breaks and deprotected telomeres in Arabidopsis
  4. 624
    “…BACKGROUND: Among the numerous genetic defects associated with hepatocarcinogenesis, telomere abnormalities appear to play a role both in tumor promotion and maintenance. …”
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    Cause-specific telomere factors deregulation in hepatocellular carcinoma
  5. 625
    por Kim, Mi Kyung, Smith, Susan
    Publicado 2014
    “…Telomeres use distinct mechanisms (not used by arms or centromeres) to mediate cohesion between sister chromatids. …”
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    Persistent telomere cohesion triggers a prolonged anaphase
  6. 626
    “…Telomeric DNAs consist of tandem repeats of G-clusters such as TTAGGG and TG(1-3), which are the human and yeast repeat sequences, respectively. …”
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    Telomeric repeats act as nucleosome-disfavouring sequences in vivo
  7. 627
    “…Telomeres are specialized nucleoprotein assemblies that protect the ends of linear chromosomes. …”
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    Molecular Recognition in Complexes of TRF Proteins with Telomeric DNA
  8. 628
    “…Telomeres, nucleoprotein structures at the ends of linear eukaryotic chromosomes, are important for the maintenance of genomic stability. …”
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    Compromised telomere maintenance in hypomethylated Arabidopsis thaliana plants
  9. 629
    “…Following adverse childhood experiences, high quality maternal care can protect against accelerated telomere shortening in peripheral cells. It is less clear, however, how telomere length in the brain is influenced by early caregiving experiences. …”
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    Infant-Caregiver Experiences Alter Telomere Length in the Brain
  10. 630
    “…Leukocyte telomere length (LTL) is longer in association with advanced paternal age, but this association has not been examined along with family history (FH) in schizophrenia. …”
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    Telomere length, family history, and paternal age in schizophrenia
  11. 631
    “…In addition, Tet TKO ESCs exhibited increased telomere–sister chromatid exchange and elongated telomeres. …”
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    Role of Tet proteins in enhancer activity and telomere elongation
  12. 632
    “…We observed increased aneuploidy in Cdk4(R/R) fibroblasts along with significantly elevated telomerase activity and telomere length in Cdk4(R/R) islets and embryonic fibroblasts. …”
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    Telomere dysfunction suppresses multiple endocrine neoplasia in mice
  13. 633
    “…This method enables us to determine, for the first time, that telomere organization is cell-cycle dependent, with assembly of telomeres into a telomeric disk in the G2 phase. …”
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    The three-dimensional organization of telomeres in the nucleus of mammalian cells
  14. 634
    “…The role telomeres and telomerase play in the initiation and progression of human cancers has been extensively evaluated. …”
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    The potential utility of telomere-related markers for cancer diagnosis
  15. 635
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    Telomeres, Atherosclerosis, and Human Longevity: A Causal Hypothesis
  16. 636
    “…Using conventional cytogenetic and fluorescence in situ hybridization studies, we identified a high number of telomeric associations (TAs). Moreover, telomere length measurements by terminal restriction fragment (TRF) assay showed a shorter mean TRF peak value, with a consistent correlation with the number of TAs. …”
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    Expression profile of telomere-associated genes in multiple myeloma
  17. 637
    “…We found that daughters of depressed mothers had shorter telomeres than did daughters of never-depressed mothers and, further, that shorter telomeres were associated with greater cortisol reactivity to stress. …”
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    Telomere length and cortisol reactivity in children of depressed mothers
  18. 638
    “…The purpose of the work was to investigate telomere length (TL) and mechanisms involved in TL maintenance in individual neuroblastoma (NB) tumors. …”
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    Intratumoral diversity of telomere length in individual neuroblastoma tumors
  19. 639
    “…Importantly, deleting the gene encoding telomere associated silencing factor SIR3 abolishes telomere grouping and decreases longevity, a defect that is rescued by expressing a silencing defective SIR3 allele competent for hypercluster formation. …”
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    Spatial reorganization of telomeres in long-lived quiescent cells
  20. 640
    “…Cells surviving crisis are often tumorigenic and their telomeres are commonly maintained through the reactivation of telomerase. …”
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    Telomere maintenance through recruitment of internal genomic regions
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