Mostrando 721 - 740 Resultados de 8,819 Para Buscar 'Telonero~', tiempo de consulta: 6.25s Limitar resultados
  1. 721
    “…AIM: To determine whether it was predictive of genetic anticipation, we evaluated telomere length in IBD. We hypothesized that multiplex IBD families exhibit a genetic defect impacting telomere maintenance mechanisms. …”
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  2. 722
    “…BACKGROUND: Telomeres are vital for genomic integrity, and telomere length has been linked to many adverse health outcomes. …”
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  3. 723
    “…Lagging-strand telomeres lacking TRF1 or BLM form fragile telomeres—structures that resemble common fragile sites (CFSs)—but how they are formed is not known. …”
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  4. 724
    “…Mitochondrial dysfunction and telomere shortening have been implicated in both the pathophysiology of bipolar disorder and as targets of lithium treatment. …”
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  5. 725
    “…Consequently, its substrates, i.e. telomeres, get shorter in most human cells with time. …”
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  6. 726
  7. 727
    “…BACKGROUND: Prior studies in humans have suggested that telomere shortening may be accelerated by infection, but research on multiple pathogens and use of large population-based study samples has been limited. …”
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  8. 728
    “…The present review aimed to summarise the current knowledge of the association between telomeres and ageing-related kidney diseases and explored the contribution of dysfunctional telomeres to these diseases. …”
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  9. 729
    “…BACKGROUND: Telomere length in early life predicts later length, and shortened telomere length among adults and children has been linked to increased risk of chronic disease and mortality. …”
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  10. 730
    “…We review the contributing factors to post-MI remodeling, its association with telomere biology, as well as a myriad of other factors affecting aging and telomere length in relation to cardiovascular health. …”
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  11. 731
    por Newton, Chad
    Publicado 2020
    “…Telomeres shorten with age; therefore, telomere dysfunction is of particular relevance for understanding age-related disease mechanisms. …”
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  12. 732
    “…At present, the key questions concerning the driving force behind their rapid evolution and the means of co-evolution of telomeric repeats and telomere-binding proteins remain largely unanswered. …”
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  13. 733
    “…Moreover, quantitative analysis of telomere dysfunction-induced foci (TIFs) revealed that maternal obesity induces the defective telomeres in oocytes and embryos. …”
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  14. 734
  15. 735
  16. 736
  17. 737
    “…This is accomplished through the conserved specialized nucleoprotein structure of telomeres. Due to the repetitive nature of telomeric DNA, and the unusual terminal structure, namely a protruding single stranded 3′ DNA end, completing telomeric DNA replication in a timely and efficient manner is a challenge. …”
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  18. 738
    “…BACKGROUND: Accelerated aging and telomere shortening have been studied in many chronic diseases such as interstitial pulmonary fibrosis and chronic obstructive pulmonary disease. …”
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  19. 739
    “…Atopic diseases can impose a significant burden on children and adolescents. Telomere length is a cellular marker of aging reflecting the impact of cumulative stress exposure on individual health. …”
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  20. 740
    “…The human lifespan is strongly influenced by telomere length (TL) which is defined in a zygote—when two highly specialised haploid cells form a new diploid organism. …”
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