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Mostrando 1,101 - 1,120 Resultados de 8,819 Para Buscar 'Telonero~', tiempo de consulta: 3.71s Limitar resultados
  1. 1101
    “…Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. …”
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    Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo
  2. 1102
    “…Telomerase is essential to maintain telomere length in most eukaryotes. Other functions for telomerase have been proposed but molecular mechanisms remain unclear. …”
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    High incidence of rapid telomere loss in telomerase-deficient Caenorhabditis elegans
  3. 1103
    “…In MCF-7 cells, experimental telomere loop disruption caused identical responses, consistent with the hypothesis that T-oligos act by mimicking telomere overhang exposure. …”
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    Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells
  4. 1104
    “…Telomere length regulation is an important aspect of cell maintenance in eukaryotes, since shortened telomeres can lead to a number of defects, including impaired cell division. …”
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    Short telomeres in short-lived males: what are the molecular and evolutionary causes?
  5. 1105
    Publicado 1986
    “…Telomeres are essential structures that stabilize the ends of eukaryotic chromosomes and allow complete replication of linear DNA molecules. …”
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    Microinjected Tetrahymena rDNA ends are not recognized as telomeres in Xenopus eggs
  6. 1106
    Publicado 1996
    “…Mammalian telomeres are composed of long arrays of TTAGGG repeats complexed with the TTAGGG repeat binding factor, TRF. …”
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    Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex
  7. 1107
    “…Drosophila telomeres are formed by two non-LTR retrotransposons, HeT-A and TART, which transpose only to chromosome ends. …”
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    Gag proteins of the two Drosophila telomeric retrotransposons are targeted to chromosome ends
  8. 1108
    “…Centromeres, telomeres, and ribosomal gene clusters consist of repetitive DNA sequences. …”
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    Intranuclear Anchoring of Repetitive DNA Sequences: Centromeres, Telomeres, and Ribosomal DNA
  9. 1109
    “…It is triggered as a stereotypic response to unrepaired nuclear DNA damage or to uncapped telomeres. In addition to a direct role of nuclear DNA double-strand breaks as inducer of a DNA damage response, two more subtle types of DNA damage induced by physiological levels of reactive oxygen species (ROS) can have a significant impact on cellular senescence: Firstly, it has been established that telomere shortening, which is the major contributor to telomere uncapping, is stress dependent and largely caused by a telomere-specific DNA single-strand break repair inefficiency. …”
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    DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
  10. 1110
    “…Telomeres are known to prevent chromosome ends from being recognized as DNA double-strand breaks. …”
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    Role of ATM in the telomere response to the G-quadruplex ligand 360A
  11. 1111
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    Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?
  12. 1112
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    Sub-Telomere Directed Gene Expression during Initiation of Invasive Aspergillosis
  13. 1113
    “…Telomere dysfunction is known to induce growth arrest (senescence) and cell death. …”
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    TOR Regulates Cell Death Induced by Telomere Dysfunction in Budding Yeast
  14. 1114
    “…We report here that increased telomerase activity results in increased telomere length that eventually reaches a plateau, accompanied by the generation of telomere length heterogeneity and the accumulation of extrachromosomal telomeric repeat DNA, principally in the form of telomeric circles (t-circles). …”
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    Control of telomere length by a trimming mechanism that involves generation of t-circles
  15. 1115
    “…Effects of natural isoflavones on the structural competition of human telomeric G-quadruplex d[AG(3)(T(2)AG(3))(3)] and its related Watson–Crick duplex d[AG(3)(T(2)AG(3))(3)-(C(3)TA(2))(3)C(3)T] are investigated by using circular dichroism (CD), ESI-MS, fluorescence quenching measurement, CD stopped-flow kinetic experiment, UV spectroscopy and molecular modeling methods. …”
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    Natural isoflavones regulate the quadruplex–duplex competition in human telomeric DNA
  16. 1116
    “…The arrangement of the human telomeric quadruplex in physiologically relevant conditions has not yet been unambiguously determined. …”
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    Arrangements of human telomere DNA quadruplex in physiologically relevant K(+) solutions
  17. 1117
    “…BACKGROUND: Telomere length is considered as a biomarker of aging, stress, cancer. …”
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    Telomere Length in Human Adults and High Level Natural Background Radiation
  18. 1118
    por Olive, Peggy L.
    Publicado 2009
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    Endogenous DNA breaks: γH2AX and the role of telomeres
  19. 1119
    “…Telomerase has the potential to interfere with repair by inappropriately adding telomeres to DNA breaks. It was unknown whether cells modulate telomerase in response to DNA damage, to increase the accuracy of repair. …”
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    DNA damage signalling prevents deleterious telomere addition at DNA breaks
  20. 1120
    “…Telomeres undergo attrition with each cell division, and telomere length is associated with age-related diseases and mortality in the elderly. …”
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    Effect of Long-Term Hormone Therapy on Telomere Length in Postmenopausal Women
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