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  1. 1221
    “…However, little is known about the role of the FPC at other natural impediments including telomeres. Telomeres are considered to be difficult to replicate due to the presence of repetitive GT-rich sequences and telomere-binding proteins. …”
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    Swi1(Timeless) Prevents Repeat Instability at Fission Yeast Telomeres
  2. 1222
    por Bär, Christian, Blasco, Maria A.
    Publicado 2016
    “…Telomeres, the protective ends of linear chromosomes, shorten throughout an individual’s lifetime. …”
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    Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases
  3. 1223
    “…Telomeric regions contain prominent sites of heterochromatin, which is associated with unique histone modification profiles such as the methylation of histone H3 at Lys9 (H3K9me). …”
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    The proper connection between shelterin components is required for telomeric heterochromatin assembly
  4. 1224
    “…Telomeres are areas of heterochromatin composed of TTAGGG repeats located at the ends of linear chromosomes. …”
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    Beyond Telomerase: Telomere Instability as a Novel Target for Cancer Therapy
  5. 1225
    “…The objective of this study was to determine whether there is an association between urinary phthalate metabolites [mono-ethyl phthalate (MEP), mono-butyl phthalate (MBP), mono-(2-ethyl)-hexyl phthalate (MEHP), and mono-benzyl phthalate (MBzP) and leukocyte telomere length (LTL) in the adult population of the National Health and Nutrition Examination Survey (NHANES) 1999–2002 (n = 2472). …”
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    Urinary Phthalates and Leukocyte Telomere Length: An Analysis of NHANES 1999–2002
  6. 1226
    “…PURPOSE: Telomere shortening occurs in tumor tissues and peripheral blood lymphocytes of many common human malignancies, including lung cancer, but its variation in T-cells has never been investigated. …”
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    Shorter telomere length of T-cells in peripheral blood of patients with lung cancer
  7. 1227
    “…BACKGROUND: Telomere length and DNA methylation have been proposed as biological clock measures that track chronological age. …”
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    The epigenetic clock and telomere length are independently associated with chronological age and mortality
  8. 1228
    “…Telomere length (TL) in early life has been found to be predictive of subsequent lifespan. …”
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    Embryonic and postnatal telomere length decrease with ovulation order within clutches
  9. 1229
    “…Surprisingly, stability of the R-triplex formed by telomeric sequence depends strikingly on the counter ion, being higher for Na(+) than for Li(+). …”
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    Conformational variability of recombination R-triplex formed by the mammalian telomeric sequence
  10. 1230
    “…Although telomere length is genetically determined, mouse embryonic stem (ES) cells with telomeres of twice the normal size have been generated. …”
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    Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations
  11. 1231
    por Nersisyan, Lilit
    Publicado 2016
    “…Telomere length dynamics plays a crucial role in regulation of cellular processes and cell fate. …”
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    Integration of Telomere Length Dynamics into Systems Biology Framework: A Review
  12. 1232
    “…Here, we demonstrate that a TH59 derivative, HPTH59-b, along with immunostaining for specifying cell types in the tissues, visualizes telomeres in mouse and human tissue sections. Quantitative measurements of telomere length with single-cell resolution suggested shorter telomeres in the proliferating cell fractions of tumor than in non-tumor tissues. …”
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    Telomere Visualization in Tissue Sections using Pyrrole–Imidazole Polyamide Probes
  13. 1233
    “…Telomeres prevent chromosome ends from being recognized as double-stranded breaks (DSBs). …”
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    Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells
  14. 1234
    “…BACKGROUND: Telomere length <1st percentile‐for‐age in leukocyte subsets by flow cytometry with fluorescence in situ hybridization (flow FISH) is highly sensitive and specific in diagnosing patients with dyskeratosis congenita (DC), a telomere biology disorder. …”
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    The limitations of qPCR telomere length measurement in diagnosing dyskeratosis congenita
  15. 1235
    por Greider, Carol W.
    Publicado 2016
    “…Telomere length is regulated around an equilibrium set point. …”
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    Regulating telomere length from the inside out: the replication fork model
  16. 1236
    “…BACKGROUND: Telomere erosion can lead to genomic instability and cancer progression. …”
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    Short telomere length and its correlation with gene mutations in myelodysplastic syndrome
  17. 1237
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    Telomeric repeat silencing in germ cells is essential for early development in Drosophila
  18. 1238
    “…PBMCs were isolated and analyzed using quantitative PCR to determine telomere length. The association between HIV infection, demographic and clinical characteristics, and telomere length was assessed, as were the associations between telomere length, TB diagnosis and 2-month mortality. …”
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    HIV Infection Is Associated with Shortened Telomere Length in Ugandans with Suspected Tuberculosis
  19. 1239
    “…Whether or not telomerase preferentially extends the shortest telomeres is still under debate. When human cancer cells are cultured at neutral pH, telomerase extends telomeres in telomere length-independent manner. …”
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    Preferential extension of short telomeres induced by low extracellular pH
  20. 1240
    “…Telomere length was measured in leukocyte DNA samples by Q‐PCR. …”
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    Leukocyte telomere length in relation to the risk of Barrett's esophagus and esophageal adenocarcinoma
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