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  1. 1521
    “…Telomeres, repetitive DNA sequences that promote chromosomal stability, have been related to different measures of mental well-being and self-rated health, but mainly in women during adulthood. …”
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    Telomere Length and Mental Well-Being in Elderly Men from the Netherlands and Greece
  2. 1522
    “…The loss of telomere function can result in the fusion of telomeres with other telomeric loci, or non-telomeric double-stranded DNA breaks. …”
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    Mre11 modulates the fidelity of fusion between short telomeres in human cells
  3. 1523
    “…Telomere shortening and disruption of telomeric components are pathways that induce telomere deprotection. …”
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    A Telomere Dependent DNA Damage Checkpoint Induced by Prolonged Mitotic Arrest
  4. 1524
    “…Aging is characterized by shortening of telomeres. The relationship of telomere length to important clinical outcomes such as mortality, disease progression and cancer in COPD is unknown. …”
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    The Relationship between Telomere Length and Mortality in Chronic Obstructive Pulmonary Disease (COPD)
  5. 1525
    “…Most cancer cells accumulate genomic abnormalities at a remarkably rapid rate, as they are unable to maintain their chromosome structure and number. Excessively short telomeres, a known source of chromosome instability, are observed in early human-cancer lesions. …”
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    Progressive Telomere Dysfunction Causes Cytokinesis Failure and Leads to the Accumulation of Polyploid Cells
  6. 1526
    “…Telomerase activity is readily detectable in extracts from human hematopoietic stem and progenitor cells, but appears unable to maintain telomere length with proliferation in vitro and with age in vivo. …”
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    Collapse of Telomere Homeostasis in Hematopoietic Cells Caused by Heterozygous Mutations in Telomerase Genes
  7. 1527
    “…The aim of this work was to compare transcriptional silencing in haploids and diploids at both telomeres and the hidden mating-type (HM) loci. Transcriptional silencing was assayed, by growth on 5-fluoroorotic acid (5-FOA) media or by flow cytometry, on strains where a telomere or HM locus was marked. …”
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    Apparent Ploidy Effects on Silencing Are Post-Transcriptional at HML and Telomeres in Saccharomyces cerevisiae
  8. 1528
    “…Telomeres, the essential terminal regions of linear eukaryotic chromosomes, consist of G-rich DNA repeats bound by a plethora of associated proteins. …”
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    Selaginella moellendorffii telomeres: conserved and unique features in an ancient land plant lineage
  9. 1529
    “…BACKGROUND: Telomeres are nucleoprotein complexes at the end of linear eukaryotic chromosomes which maintain the genome integrity by regulating telomere length, preventing recombination and end to end fusion events. …”
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    Functional diversification of yeast telomere associated protein, Rif1, in higher eukaryotes
  10. 1530
    “…The aim of this study is to characterize telomeric and subtelomeric regions of T. cruzi available in TriTrypDB and connect the sequences of telomeres to T. cruzi working draft sequence. …”
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    Anatomy and evolution of telomeric and subtelomeric regions in the human protozoan parasite Trypanosoma cruzi
  11. 1531
    “…In the yeast Saccharomyces cerevisiae, the establishment and maintenance of silent chromatin at the telomere requires a delicate balance between opposing activities of histone modifying enzymes. …”
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    Recruitment of Rpd3 to the Telomere Depends on the Protein Arginine Methyltransferase Hmt1
  12. 1532
    “…BACKGROUND: Telomere length, an indicator of ageing and longevity, has been correlated with several biomarkers of cardiometabolic disease in both Arab children and adults. …”
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    Circulating leukocyte telomere length is highly heritable among families of Arab descent
  13. 1533
    “…BACKGROUND: Rodents have been reported to contain large arrays of interstitial telomeric sequences (TTAGGG)n (ITS) located in pericentromeric heterochromatin. …”
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    Characterization of telomeric repeats in metaphase chromosomes and interphase nuclei of Syrian Hamster Fibroblasts
  14. 1534
    “…Linear regression analyses, adjusted for age, sex, and telomere length measured at the first assessment wave (T1), showed that low intelligence was associated with shorter leukocyte telomere length at approximately 2 years follow-up (beta = .081, t = 2.160, p = .031). …”
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    The Association between Intelligence and Telomere Length: A Longitudinal Population Based Study
  15. 1535
    “…[Image: see text] Inorganic arsenic is a strong carcinogen, possibly by interaction with the telomere length. The aim of the study was to evaluate how chronic arsenic exposure from drinking water as well as the arsenic metabolism efficiency affect the individual telomere length and the expression of telomere-related genes. …”
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    Arsenic Exposure through Drinking Water Is Associated with Longer Telomeres in Peripheral Blood
  16. 1536
    “…FANCD2 lymphocytes exhibited multiple types of telomeric abnormalities, including premature telomere shortening, increase in telomeric recombination and aberrant telomeric structures ranging from fragile to long-string extended telomeres. …”
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    Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients
  17. 1537
    “…Telomeres in cells that use the recombination-mediated alternative lengthening of telomeres (ALT) pathway elicit a DNA damage response that is partly independent of telomere length. …”
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    Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells
  18. 1538
    “…Human chromosome ends are capped by shelterin, a protein complex that protects the natural ends from being recognized as sites of DNA damage and also regulates the telomere-replicating enzyme, telomerase(1–3). Shelterin includes the heterodimeric POT1-TPP1 protein, which binds the telomeric single-stranded DNA tail(4–9). …”
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    The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity
  19. 1539
    “…OBJECTIVES: Recent studies have shown that telomere length was significantly reduced in placentas collected at delivery from pregnancies complicated by intrauterine growth restriction secondary to placental insufficiency. …”
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    Reduced Placental Telomere Length during Pregnancies Complicated by Intrauterine Growth Restriction
  20. 1540
    “…The mammalian Protection Of Telomeres (POT1) protein interacts with single-stranded telomeric DNA and can exert positive and negative effects on telomere length. …”
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    Caenorhabditis elegans POT-1 and POT-2 Repress Telomere Maintenance Pathways
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