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  1. 1561
    “…Here, we describe a model in which telomeric repeat-binding factor 2 (TERF2) can control tumorigenesis not only via cancer cell-intrinsic mechanisms but also via non-cancer cell autonomous pathways. …”
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    A novel pathway links telomeres to NK-cell activity: Implications for immunotherapy
  2. 1562
    “…In this report, we examine the short-term effect of chiral metallo-supramolecular complex enantiomers treatment on tumor cells, and find that a zinc-finger-like alpha helical chiral metallo-supramolecular complex, [Ni(2)L(3)](4+)-P enantiomer (NiP), can selectively provoke the rapid telomere uncapping, trigger DNA damage responses at telomere and degradation of G-overhang and the delocalization of telomeric protein from telomeres. …”
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    G-Quadruplex binding enantiomers show chiral selective interactions with human telomere
  3. 1563
    “…Telomeres are guanine-rich sequences at the end of chromosomes which shorten during each replication event and trigger cell cycle arrest and/or controlled death (apoptosis) when reaching a threshold length. …”
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    Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs
  4. 1564
    “…Telomeres, the caps of eukaryotic chromosomes, control chromosome stability and cellular senescence, but aging and exposure to chronic stress are suspected to cause attrition of telomere length. …”
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    Social Isolation Shortens Telomeres in African Grey Parrots (Psittacus erithacus erithacus)
  5. 1565
    “…Mammalian telomeric DNA consists of tandem repeats of the sequence TTAGGG associated with a specialized set of proteins, known collectively as Shelterin. …”
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    The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines
  6. 1566
    “…As previously reported, the ribonucleoprotein, hnRNP Al, and it is proteolytic derivative, unwinding protein 1 (UP1), bind to and destabilize G-quadruplex structures formed by the human telomeric repeat d(TTAGGG)(n). UP1 has been proposed to be involved in the recruitment of telomerase to telomeres for chain extension. …”
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    Recognition and Binding of Human Telomeric G-Quadruplex DNA by Unfolding Protein 1
  7. 1567
    “…Here we establish that telomeric repeat-binding factor 1 (TRF1), a core component of the telomere protein complex, is a mediator of telomere associations in mammalian cells. …”
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    Resolution of telomere associations by TRF1 cleavage in mouse embryonic stem cells
  8. 1568
    “…Objective To assess the association between leucocyte telomere length and risk of cardiovascular disease. …”
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    Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis
  9. 1569
    “…INTRODUCTION: Shortening of telomere is associated with cellular senescence and cancer. …”
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    Telomere instability in papillary bladder urothelial carcinomas: Comparison with grading and risk of recurrence
  10. 1570
    “…BACKGROUND: There have been several reports suggesting that adverse childhood experiences such as physical maltreatment and long institutionalization influence telomere length. However, there has been no study examining the relationship of telomere length with variations in parental rearing. …”
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    Parental care influences leukocyte telomere length with gender specificity in parents and offsprings
  11. 1571
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    RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP
  12. 1572
    “…DNA damage and telomere dysfunction shorten organismal lifespan. Here we show that oral glucose administration at advanced age increases health and lifespan of telomere dysfunctional mice. …”
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    Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice
  13. 1573
    “…The replication time of Saccharomyces cerevisiae telomeres responds to TG(1–3) repeat length, with telomeres of normal length replicating late during S phase and short telomeres replicating early. …”
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    At Short Telomeres Tel1 Directs Early Replication and Phosphorylates Rif1
  14. 1574
    “…Telomeres are important in aging processes and carcinogenesis. …”
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    Telomere length in Chernobyl accident recovery workers in the late period after the disaster
  15. 1575
    por Cesare, Anthony J
    Publicado 2014
    “…It was shown that restoring mitotic DSB repair was detrimental, resulting in repair dependent genome instability and covalent telomere fusions. The telomere DDR that occurs naturally during cellular aging and in cancer is known to be refractory to G2/M checkpoint activation. …”
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    Mitosis, double strand break repair, and telomeres: A view from the end
  16. 1576
    “…Background: In eutherian mammals and in humans, the female fetus may be masculinized while sharing the intra-uterine environment with a male fetus. Telomere length (TL), as expressed in leukocytes, is heritable and is longer in women than in men. …”
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    Sex difference in leukocyte telomere length is ablated in opposite-sex co-twins
  17. 1577
    por Fairlie, Jennifer, Harrington, Lea
    Publicado 2015
    “…More than 85% of all human cancers possess the ability to maintain chromosome ends, or telomeres, by virtue of telomerase activity. Loss of functional telomeres is incompatible with survival, and telomerase inhibition has been established in several model systems to be a tractable target for cancer therapy. …”
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    Enforced telomere elongation increases the sensitivity of human tumour cells to ionizing radiation
  18. 1578
    “…In approximately thirty percent of glioblastoma multiforme tumors, telomeres are not maintained by telomerase but through an alternative mechanism, termed alternative lengthening of telomere (ALT), suggesting potential interest in developing specific therapeutic strategies. …”
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    A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT)
  19. 1579
    “…The helicase RTEL1 promotes t-loop unwinding and suppresses telomere fragility to maintain the integrity of vertebrate telomeres. …”
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    TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding
  20. 1580
    “…Interaction network surrounding telomeres has been intensively studied during the past two decades. …”
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    TeloPIN: a database of telomeric proteins interaction network in mammalian cells
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