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  1. 1581
    “…INTRODUCTION: Cushing’s syndrome (CS) increases cardiovascular risk (CVR) and adipocytokine imbalance, associated with an increased inflammatory state. Telomere length (TL) shortening is a novel CVR marker, associated with inflammation biomarkers. …”
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    Dyslipidemia and Chronic Inflammation Markers Are Correlated with Telomere Length Shortening in Cushing’s Syndrome
  2. 1582
    por Uziel, Orit, Lahav, Meir
    Publicado 2014
    “…In a previous study, we have shown that shortening of telomeres by telomerase inhibition sensitized cancer cells to cisplatinum, slower their migration, increased DNA damage and impaired DNA repair [1]. …”
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    Proteomic and microRNA data clarifying the effects of telomere shortening on cancer cells
  3. 1583
    “…Psychosis is associated with a disequilibrium between free radical production and antioxidative defense. Although telomere attrition has been demonstrated in schizophrenia, no relationship has been reported between telomere length and severity of schizophrenia. …”
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    Telomere length in blood cells is related to the chronicity, severity, and recurrence rate of schizophrenia
  4. 1584
    “…Here, we analyze the response of primary human cells and murine hematopoietic stem cells (HSCs) to aneuploidy induction and the role of telomeres and the telomerase in this process. The study shows that aneuploidy induces replication stress at telomeres leading to telomeric DNA damage and p53 activation. …”
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    Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion
  5. 1585
    “…Cellular DNA is organized into chromosomes and capped by a unique nucleoprotein structure, the telomere. Both oxidative stress and telomere shortening/dysfunction cause aging-related degenerative pathologies and increase cancer risk. …”
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    Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death
  6. 1586
    “…Telomere length, a highly heritable trait, is longer in offspring of older fathers. …”
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    Paternal age and telomere length in twins: the germ stem cell selection paradigm
  7. 1587
    “…BACKGROUND: Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. …”
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    Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort
  8. 1588
    “…Super-resolution microscopy revealed that over 50% of telomeres localize to the lamina and that LAP2α association with telomeres is impaired in HGPS. …”
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    Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria
  9. 1589
    “…BACKGROUND: Replicative senescence, associated with telomere shortening, plays an important role in aging and cardiovascular disease. …”
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    Telomere length, cardiovascular risk and arteriosclerosis in human kidneys: an observational cohort study
  10. 1590
    “…Telomere integrity in Drosophila melanogaster is maintained by a putative multisubunit complex called terminin that is believed to act in analogy to the mammalian shelterin complex in protecting chromosome ends from being recognized as sites of DNA damage. …”
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    Cross-Species Interaction between Rapidly Evolving Telomere-Specific Drosophila Proteins
  11. 1591
    “…Background: A longer leukocyte telomere length (LTL) in women than men has been attributed to a slow rate of LTL attrition in women, perhaps due to high estrogen exposure during the premenopausal period. …”
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    Leukocyte telomere length dynamics in women and men: menopause vs age effects
  12. 1592
    “…In particular, we analyze the shape of telomere length distributions underlying stem cell behavior within individuals. …”
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    Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions
  13. 1593
    “…Mph1 and Mte1 interdependently colocalize at DNA damage-induced foci and dysfunctional telomeres, and MTE1 deletion results in elongated telomeres. …”
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    Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance
  14. 1594
    por Nakai-Futatsugi, Yoko, Niwa, Hitoshi
    Publicado 2016
    “…ZSCAN4 is a DNA-binding protein that functions for telomere elongation and genomic stability. In vivo, it is specifically expressed at the two-cell stage during mouse development. …”
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    Zscan4 Is Activated after Telomere Shortening in Mouse Embryonic Stem Cells
  15. 1595
    “…Telomere attrition is linked to cancer, diabetes, cardiovascular disease and aging. …”
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    Rif1 and Exo1 regulate the genomic instability following telomere losses
  16. 1596
    por Cai, Qiuyin
    Publicado 2016
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    Telomere length: A possible link between phthalate exposure and cancer development?
  17. 1597
    “…In contrast, positive relationships were identified between Alu and LINE-1 methylation and relative telomere length in BA patients (P < 0.0001). These findings suggest that retrotransposon hypomethylation is associated with plasma 8-OHdG and telomere length in BA patients.…”
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    Global methylation, oxidative stress, and relative telomere length in biliary atresia patients
  18. 1598
    “…Telomeres are important for maintaining the integrity of the genome through the action of the shelterin complex. …”
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    Telomere protein RAP1 levels are affected by cellular aging and oxidative stress
  19. 1599
    “…Telomeres are specific structures that protect chromosome ends and act as a biological clock, preventing normal cells from replicating indefinitely. …”
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    Replication Timing of Human Telomeres is Conserved during Immortalization and Influenced by Respective Subtelomeres
  20. 1600
    “…BACKGROUND: Patients with short telomere syndromes and pulmonary fibrosis have increased complications after lung transplant. …”
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    Association of Donor and Recipient Telomere Length with Clinical Outcomes following Lung Transplantation
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