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  1. 1641
    “…BACKGROUND: Telomere defects are thought to play a role in cardiomyopathies, but the specific cell type affected by the disease in human hearts is not yet identified. …”
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    Cardiomyocyte‐Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans
  2. 1642
    “…BACKGROUND: Telomere length is an emerging novel biomarker of biologic age, cardiovascular risk and chronic medical conditions. …”
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    Telomere attrition, kidney function, and prevalent chronic kidney disease in the United States
  3. 1643
    “…Here, we investigated the function of the major RNR subunits Rnr1 and Rnr3 in telomere elongation in budding yeast. We show that Rnr1 is essential for the sustained elongation of short telomeres by telomerase. …”
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    Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres
  4. 1644
    “…Increased inflammation and oxidative stress associated with obesity can accelerate aging. Telomere length (TL) has the capacity to serve as an aging indicator at the cellular level. …”
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    Changes in Telomere Length 3-5 years after Gastric Bypass Surgery
  5. 1645
    “…Telomere maintenance dysfunction has been implicated in the pathogenesis of Idiopathic Pulmonary Fibrosis (IPF). …”
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    Short telomere length in IPF lung associates with fibrotic lesions and predicts survival
  6. 1646
    “…We ascertained that such telomere-proximal facultative heterochromatin requires native telomere repeats and found that a short array of ectopic telomere repeats, (TTAGGG)(17,) can induce a large domain (~225 kb) of H3K27me2/3. …”
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    Telomere repeats induce domains of H3K27 methylation in Neurospora
  7. 1647
    “…BACKGROUND: Sarcopenia is defined as the loss of muscle mass or function with aging and is associated with adverse outcomes. Telomere shortening is associated with mortality, yet its relationship with sarcopenia is unknown. …”
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    The Association of Sarcopenia, Telomere Length and Mortality: Data from the NHANES 1999–2002
  8. 1648
    “…Twenty-one telomere maintenance genes are differentially expressed in Myotis, of which 14 are enriched for DNA repair, and 5 for alternative telomere-lengthening mechanisms. …”
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    Growing old, yet staying young: The role of telomeres in bats’ exceptional longevity
  9. 1649
    “…Telomeres contain TTAGGG repetitive sequences and are located at the end of human chromosomes. …”
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    Foods, Dietary Patterns and Occupational Class and Leukocyte Telomere Length in the Male Population
  10. 1650
    “…We investigated whether critically ill children admitted to the PICU have shorter-than-normal telomeres, and whether early parenteral nutrition (PN) independently affects telomere length when adjusting for known determinants of telomere length. …”
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    Leukocyte telomere length in paediatric critical illness: effect of early parenteral nutrition
  11. 1651
    “…Recent studies have linked constitutive telomere length (TL) to aging-related diseases including cancer at different sites. …”
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    Telomere length, ATM mutation status and cancer risk in Ataxia-Telangiectasia families
  12. 1652
    “…Telomere length is a prognostic biomarker for aging diseases. …”
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    Leukocyte telomere length and diet in the apparently healthy, middle-aged Asklepios population
  13. 1653
    “…Recent observations have reported the existence of telomeric repeats containing long ncRNAs – TERRA in mammalian and yeast cells. …”
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    Expression of Subtelomeric lncRNAs Links Telomeres Dynamics to RNA Decay in S. cerevisiae
  14. 1654
    por Özer, Özgün, Hickson, Ian D.
    Publicado 2018
    “…Certain regions of the human genome, such as common fragile sites and telomeres, are particularly sensitive to DNA replication stress due to their inherently ‘difficult-to-replicate’ nature. …”
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    Pathways for maintenance of telomeres and common fragile sites during DNA replication stress
  15. 1655
    “…BACKGROUND: The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences in complex with proteins that protects them from being processed by the DNA repair machinery. …”
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    TelNet - a database for human and yeast genes involved in telomere maintenance
  16. 1656
    “…Telomere length significantly increased between the embryonic and larval stages of development. …”
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    Telomere elongation during early development is independent of environmental temperatures in Atlantic salmon
  17. 1657
    “…A more proximal bulged stem with the CS2 element is thought to associate with Est1, a telomerase protein required for telomerase recruitment to telomeres. Previous work found that changes in CS2a cause a loss of all stem IVc proteins, not just the Pop proteins. …”
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    The yeast telomerase module for telomere recruitment requires a specific RNA architecture
  18. 1658
    “…The present study aims to explore the potential influence of leucocyte telomere length (LTL) on both a single indicator and a composite construct of physical functioning in a large European population of elderly men and women across diverse geographical locations. …”
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    Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults
  19. 1659
    “…In humans, telomere studies have mainly relied on measurements of leukocyte telomere length and it is generally accepted that individuals with short leukocyte telomere length are considered biologically older than those with longer ones. …”
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    Early Senescence and Leukocyte Telomere Shortening in SCHIZOPHRENIA: A Role for Cytomegalovirus Infection?
  20. 1660
    por Fletcher, Jason M.
    Publicado 2018
    “…Telomere length (TL) has been associated with a range of aging outcomes as well as mortality. …”
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    Spousal concordance in telomere length: New evidence from older adults in the US
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