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Mostrando 1,941 - 1,960 Resultados de 8,819 Para Buscar 'Telonero~', tiempo de consulta: 3.11s Limitar resultados
  1. 1941
    “…Quite remarkably, our experiments in yeast telomeric silencing show a very distinctive pattern when it comes to the transition from bistability to monostability. …”
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    Breaking an Epigenetic Chromatin Switch: Curious Features of Hysteresis in Saccharomyces cerevisiae Telomeric Silencing
  2. 1942
    “…The present study aims to investigate whether gastrokine 1 (GKN1) induces senescence and apoptosis in gastric cancer cells by regulating telomere length and telomerase activity. Telomere length, telomerase activity, and hTERT expression decreased significantly in AGS(GKN1) and MKN1(GKN1) cells. …”
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    Gastrokine 1 induces senescence and apoptosis through regulating telomere length in gastric cancer
  3. 1943
    “…WRN helicase is involved in the maintenance of chromosome integrity through DNA replication, repair, and recombination by interacting with a variety of proteins associated with DNA repair and telomere maintenance. The accelerated aging associated with WS is reportedly caused by telomere dysfunction, and the underlying mechanism of the disease is yet to be elucidated. …”
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    Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming
  4. 1944
    “…In conclusion, calorie restriction-triggered nitric oxide provides antioxidative protection and alleviates telomere attrition via mitochondrial biogenesis, thereby maintaining chromosomal stability and integrity, which are the hallmarks of longevity.…”
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    Artemisinin mimics calorie restriction to trigger mitochondrial biogenesis and compromise telomere shortening in mice
  5. 1945
    “…Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is a classical metabolic enzyme involved in energy production and plays a role in additional nuclear functions, including transcriptional control, recognition of misincorporated nucleotides in DNA and maintenance of telomere structure. Here, we show that the recombinant protein T. cruzi GAPDH (rTcGAPDH) binds single-stranded telomeric DNA. …”
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    Glyceraldehyde 3-Phosphate Dehydrogenase-Telomere Association Correlates with Redox Status in Trypanosoma cruzi
  6. 1946
    “…The segregation of centromeres and telomeres at mitosis is coordinated at multiple levels to prevent the formation of aneuploid cells, a phenotype frequently observed in cancer. …”
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    Aurora B prevents chromosome arm separation defects by promoting telomere dispersion and disjunction
  7. 1947
    Publicado 2015
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    Correction: Recruitment of Rpd3 to the Telomere Depends on the Protein Arginine Methyltransferase Hmt1
  8. 1948
    “…The homologous recombination (HR)-mediated repair of DSBs plays an essential role in assurance of genome stability and cell longevity. Telomeres resemble DSBs and are competent for HR. Here we show that in budding yeast Saccharomyces cerevisiae telomere recombination elicits genome instability and accelerates cellular aging. …”
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    Inhibition of Telomere Recombination by Inactivation of KEOPS Subunit Cgi121 Promotes Cell Longevity
  9. 1949
    “…Disruption of telomere maintenance pathways leads to accelerated entry into cellular senescence, a stable proliferative arrest that promotes aging-associated disorders in some mammals. …”
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    Stn1 is critical for telomere maintenance and long-term viability of somatic human cells
  10. 1950
    “…Telomerase, the enzyme that maintains telomeres, preferentially lengthens short telomeres. …”
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    The Pif1 Helicase, a Negative Regulator of Telomerase, Acts Preferentially at Long Telomeres
  11. 1951
    “…Telomere dysfunction and fusion can drive genomic instability and clonal evolution in human tumours, including breast cancer. …”
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    Telomere fusion threshold identifies a poor prognostic subset of breast cancer patients
  12. 1952
    “…It is known that glucose disturbances contribute to micro- and macrovascular complications and vascular aging. Telomere length is considered to be a cellular aging biomarker. …”
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    Short telomere length is associated with arterial aging in patients with type 2 diabetes mellitus
  13. 1953
    “…Fly telomeres are protected by the terminin complex (HOAP-HipHop-Moi-Ver) that localizes and functions exclusively at telomeres and by non-terminin proteins that do not serve telomere-specific functions. …”
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    The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres
  14. 1954
    “…Mammalian telomeres are protected by shelterin, a multiprotein complex that binds the TTAGGG telomeric repeats and recruits a series of additional factors that are essential for telomere function. …”
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    AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance
  15. 1955
    “…BACKGROUND: Telomeres are essential for chromosomal integrity and stability. …”
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    The Association between Telomere Length and Cancer Prognosis: Evidence from a Meta-Analysis
  16. 1956
    “…One possible mechanism of the ageing heart is a cellular senescence. Leukocyte telomere length (LTL) is a marker of replicative ageing. …”
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    Age-Related Left Ventricular Changes and Their Association with Leukocyte Telomere Length in Healthy People
  17. 1957
    “…Cells can become senescent by shortened telomeres and oxidative stress is known to accelerate telomere attrition. …”
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    Differential Telomere Shortening in Blood versus Arteries in an Animal Model of Type 2 Diabetes
  18. 1958
    por Hass, Evan P, Zappulla, David C
    Publicado 2015
    “…Ku binding to yeast telomerase RNA promotes telomere lengthening and telomerase recruitment to telomeres, but how this is achieved remains unknown. …”
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    The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae
  19. 1959
    “…We tested the hypothesis that IR may be associated with cellular senescence, as measured by leukocyte telomere length (LTL), and arterial stiffness (core feature of arterial aging), as measured by carotid-femoral pulse wave velocity (c-f PWV). …”
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    Association of Insulin Resistance, Arterial Stiffness and Telomere Length in Adults Free of Cardiovascular Diseases
  20. 1960
    por Zhang, Chenan, Doherty, Jennifer A., Burgess, Stephen, Hung, Rayjean J., Lindström, Sara, Kraft, Peter, Gong, Jian, Amos, Christopher I., Sellers, Thomas A., Monteiro, Alvaro N.A., Chenevix-Trench, Georgia, Bickeböller, Heike, Risch, Angela, Brennan, Paul, Mckay, James D., Houlston, Richard S., Landi, Maria Teresa, Timofeeva, Maria N., Wang, Yufei, Heinrich, Joachim, Kote-Jarai, Zsofia, Eeles, Rosalind A., Muir, Ken, Wiklund, Fredrik, Grönberg, Henrik, Berndt, Sonja I., Chanock, Stephen J., Schumacher, Fredrick, Haiman, Christopher A., Henderson, Brian E., Amin Al Olama, Ali, Andrulis, Irene L., Hopper, John L., Chang-Claude, Jenny, John, Esther M., Malone, Kathleen E., Gammon, Marilie D., Ursin, Giske, Whittemore, Alice S., Hunter, David J., Gruber, Stephen B., Knight, Julia A., Hou, Lifang, Le Marchand, Loic, Newcomb, Polly A., Hudson, Thomas J., Chan, Andrew T., Li, Li, Woods, Michael O., Ahsan, Habibul, Pierce, Brandon L.
    Publicado 2015
    “…Epidemiological studies have reported inconsistent associations between telomere length (TL) and risk for various cancers. …”
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    Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study
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