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121por Guzik, Mateusz, Urban, Szymon, Iwanek, Gracjan, Biegus, Jan, Ponikowski, Piotr, Zymliński, Robert“…Interventions regarding autonomic nervous system imbalance, i.e., baroreflex activation therapy; vagus, splanchnic and cardiopulmonary nerves modulation; respiratory disturbances, i.e., phrenic nerve stimulation and synchronized diaphragmatic therapy; decongestion management, i.e., the Reprieve system, transcatheter renal venous decongestion system, Doraya, preCardia, WhiteSwell and Aquapass, are presented. Each segment is divided into subsections: potential pathophysiological target, existing evidence and weaknesses or unexplained issues. …”
Publicado 2022
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125por Maitland, Kathryn“…There has been some progress on defining best practice for antimalarial treatment with the publication of the AQUAMAT trial in 2010, involving 5,425 children at 11 centres across 9 African countries, showing that in artesunate-treated children, the relative risk of death was 22.5% (95% confidence interval (CI) 8.1 to 36.9) lower than in those receiving quinine. …”
Publicado 2015
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127por Karus, Katrit, Zagars, Matiss, Agasild, Helen, Tuvikene, Arvo, Zingel, Priit, Puncule, Linda, Medne-Peipere, Madara, Feldmann, TõnuEnlace del recurso
Publicado 2022
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128por Husaini, Danladi Chiroma, Enriquez, Andrea, Arzu, Theslyn, Miranda, Kelcia, Mossiah, Denise, Cardinez, CrystalEnlace del recurso
Publicado 2020
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131por Luoto, Jill, Najnin, Nusrat, Mahmud, Minhaj, Albert, Jeff, Islam, M. Sirajul, Luby, Stephen, Unicomb, Leanne, Levine, David I.Enlace del recurso
Publicado 2011
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134por Moyo, Tshebukani Mzingaye, Juru, Tsitsi Patience, Sibanda, Edwin, Marape, Gladys, Gombe, Notion Tafara, Govha, Emmanuel, Tshimanga, MufutaEnlace del recurso
Publicado 2022
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135por Ramutton, Thiranut, Hendriksen, Ilse CE, Mwanga-Amumpaire, Juliet, Mtove, George, Olaosebikan, Rasaq, Tshefu, Antoinette K, Onyamboko, Marie A, Karema, Corine, Maitland, Kathryn, Gomes, Ermelinda, Gesase, Samwel, Reyburn, Hugh, Silamut, Kamolrat, Chotivanich, Kesinee, Promnares, Kamoltip, Fanello, Caterina I, von Seidlein, Lorenz, Day, Nicholas PJ, White, Nicholas J, Dondorp, Arjen M, Imwong, Mallika, Woodrow, Charles J“…METHODS: Studies designed to detect deletion of Pfhrp2 and its paralog Pfhrp3 were undertaken with samples from patients in seven countries contributing to the largest hospital-based severe malaria trial (AQUAMAT). The quantitative relationship between sequence polymorphism and PFHRP2 plasma concentration was examined in samples from selected sites in Mozambique and Tanzania. …”
Publicado 2012
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137“…In South Africa, malaria is known to be endemic in three provinces. Two large trials, AQUAMAT and SEAQUAMAT, demonstrated the superiority of intravenous (IV) artesunate compared to quinine. …”
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138por Castro, Isabel, Calatayud, M. Luisa, Orts-Arroyo, Marta, Moliner, Nicolás, Marino, Nadia, Lloret, Francesc, Ruiz-García, Rafael, Munno, Giovanni De, Julve, MiguelEnlace del recurso
Publicado 2021
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139por Mzumara, Grace, Leopold, Stije, Marsh, Kevin, Dondorp, Arjen, Ohuma, Eric O., Mukaka, Mavuto“…METHODS: A retrospective analysis of the ‘Artesunate versus quinine in the treatment of severe falciparum malaria in African children’ (AQUAMAT) trial was conducted to identify clinical features of severe metabolic acidosis and uraemia in 5425 children from nine African countries. …”
Publicado 2021
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140por Hendriksen, Ilse C. E., Mwanga-Amumpaire, Juliet, von Seidlein, Lorenz, Mtove, George, White, Lisa J., Olaosebikan, Rasaq, Lee, Sue J., Tshefu, Antoinette K., Woodrow, Charles, Amos, Ben, Karema, Corine, Saiwaew, Somporn, Maitland, Kathryn, Gomes, Ermelinda, Pan-Ngum, Wirichada, Gesase, Samwel, Silamut, Kamolrat, Reyburn, Hugh, Joseph, Sarah, Chotivanich, Kesinee, Fanello, Caterina I., Day, Nicholas P. J., White, Nicholas J., Dondorp, Arjen M.“…METHODS AND FINDINGS: Admission plasma PfHRP2 was measured prospectively in African children (from Mozambique, The Gambia, Kenya, Tanzania, Uganda, Rwanda, and the Democratic Republic of the Congo) aged 1 month to 15 years with severe febrile illness and a positive P. falciparum lactate dehydrogenase (pLDH)-based rapid test in a clinical trial comparing parenteral artesunate versus quinine (the AQUAMAT trial, ISRCTN 50258054). In 3,826 severely ill children, Plasmadium falciparum PfHRP2 was higher in patients with coma (p = 0.0209), acidosis (p<0.0001), and severe anaemia (p<0.0001). …”
Publicado 2012
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