Single-cell analysis of COVID-19, sepsis, and HIV infection reveals hyperinflammatory and immunosuppressive signatures in monocytes

por Liu, Nianping, Jiang, Chen, Cai, Pengfei, Shen, Zhuoqiao, Sun, Wujianan, Xu, Hao, Fang, Minghao, Yao, Xinfeng, Zhu, Lin, Gao, Xuyuan, Fang, Jingwen, Lin, Jun, Guo, Chuang, Qu, Kun
Publicado 2021

Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19

por Kim, Dong-Min, Kim, Yuri, Seo, Jun-Won, Lee, Jooyeon, Park, Uni, Ha, Na-Young, Koh, Jaemoon, Park, Hyoree, Lee, Jae-Won, Ro, Hyo-Jin, Yun, Na Ra, Kim, Da Young, Yoon, Sung Ho, Na, Yong Sub, Moon, Do Sik, Lim, Sung-Chul, Kim, Choon-Mee, Jeon, Kyeongseok, Kang, Jun-Gu, Jang, Na-Yoon, Jeong, Hyeongseok, Kim, Jungok, Cheon, Shinhyea, Sohn, Kyung Mok, Moon, Jae Youg, Kym, Sungmin, Han, Seung Ro, Lee, Myung-Shin, Kim, Hyun-Je, Park, Woong-Yang, Choi, Ji-Yeob, Shin, Hyun-Woo, Kim, Hye-Young, Cho, Chung-Hyun, Jeon, Yoon Kyung, Kim, Yeon-Sook, Cho, Nam-Hyuk
Publicado 2021

A highly potent antibody effective against SARS-CoV-2 variants of concern

por Fenwick, Craig, Turelli, Priscilla, Perez, Laurent, Pellaton, Céline, Esteves-Leuenberger, Line, Farina, Alex, Campos, Jérémy, Lana, Erica, Fiscalini, Flurin, Raclot, Charlène, Pojer, Florence, Lau, Kelvin, Demurtas, Davide, Descatoire, Marc, Joo, Victor S., Foglierini, Mathilde, Noto, Alessandra, Abdelnabi, Rana, Foo, Caroline S., Vangeel, Laura, Neyts, Johan, Du, Wenjuan, Bosch, Berend-Jan, Veldman, Geertruida, Leyssen, Pieter, Thiel, Volker, LeGrand, Roger, Lévy, Yves, Trono, Didier, Pantaleo, Giuseppe
Publicado 2021

Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses

por Banach, Bailey B., Cerutti, Gabriele, Fahad, Ahmed S., Shen, Chen-Hsiang, Oliveira De Souza, Matheus, Katsamba, Phinikoula S., Tsybovsky, Yaroslav, Wang, Pengfei, Nair, Manoj S., Huang, Yaoxing, Francino-Urdániz, Irene M., Steiner, Paul J., Gutiérrez-González, Matías, Liu, Lihong, López Acevedo, Sheila N., Nazzari, Alexandra F., Wolfe, Jacy R., Luo, Yang, Olia, Adam S., Teng, I-Ting, Yu, Jian, Zhou, Tongqing, Reddem, Eswar R., Bimela, Jude, Pan, Xiaoli, Madan, Bharat, Laflin, Amy D., Nimrania, Rajani, Yuen, Kwok-Yung, Whitehead, Timothy A., Ho, David D., Kwong, Peter D., Shapiro, Lawrence, DeKosky, Brandon J.
Publicado 2021

Role of miR-2392 in driving SARS-CoV-2 infection

por McDonald, J. Tyson, Enguita, Francisco J., Taylor, Deanne, Griffin, Robert J., Priebe, Waldemar, Emmett, Mark R., Sajadi, Mohammad M., Harris, Anthony D., Clement, Jean, Dybas, Joseph M., Aykin-Burns, Nukhet, Guarnieri, Joseph W., Singh, Larry N., Grabham, Peter, Baylin, Stephen B., Yousey, Aliza, Pearson, Andrea N., Corry, Peter M., Saravia-Butler, Amanda, Aunins, Thomas R., Sharma, Sadhana, Nagpal, Prashant, Meydan, Cem, Foox, Jonathan, Mozsary, Christopher, Cerqueira, Bianca, Zaksas, Viktorija, Singh, Urminder, Wurtele, Eve Syrkin, Costes, Sylvain V., Davanzo, Gustavo Gastão, Galeano, Diego, Paccanaro, Alberto, Meinig, Suzanne L., Hagan, Robert S., Bowman, Natalie M., Wolfgang, Matthew C., Altinok, Selin, Sapoval, Nicolae, Treangen, Todd J., Moraes-Vieira, Pedro M., Vanderburg, Charles, Wallace, Douglas C., Schisler, Jonathan C., Mason, Christopher E., Chatterjee, Anushree, Meller, Robert, Beheshti, Afshin
Publicado 2021

B.1.617.2 enters and fuses lung cells with increased efficiency and evades antibodies induced by infection and vaccination

por Arora, Prerna, Sidarovich, Anzhalika, Krüger, Nadine, Kempf, Amy, Nehlmeier, Inga, Graichen, Luise, Moldenhauer, Anna-Sophie, Winkler, Martin S., Schulz, Sebastian, Jäck, Hans-Martin, Stankov, Metodi V., Behrens, Georg M.N., Pöhlmann, Stefan, Hoffmann, Markus
Publicado 2021

In vivo characterization of emerging SARS-CoV-2 variant infectivity and human antibody escape potential

por Lam, Brandon, Kung, Yu Jui, Lin, John, Tseng, Ssu-Hsueh, Tsai, Ya Chea, He, Liangmei, Castiglione, Gianni, Egbert, Emily, Duh, Elia J., Bloch, Evan M., Tobian, Aaron A.R., Milstone, Aaron M., Roden, Richard B.S., Wu, Tzyy-Choou, Hung, Chien-Fu
Publicado 2021

A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration

por Wu, Xilin, Cheng, Lin, Fu, Ming, Huang, Bilian, Zhu, Linjing, Xu, Shijie, Shi, Haixia, Zhang, Doudou, Yuan, Huanyun, Nawaz, Waqas, Yang, Ping, Hu, Qinxue, Liu, Yalan, Wu, Zhiwei
Publicado 2021

Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD

por Errico, John M., Zhao, Haiyan, Chen, Rita E., Liu, Zhuoming, Case, James Brett, Ma, Meisheng, Schmitz, Aaron J., Rau, Michael J., Fitzpatrick, James A.J., Shi, Pei-Yong, Diamond, Michael S., Whelan, Sean P.J., Ellebedy, Ali H., Fremont, Daved H.
Publicado 2021

Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex

por Wu, Jiqin, Wang, Haofeng, Liu, Qiaojie, Li, Rui, Gao, Yan, Fang, Xiang, Zhong, Yao, Wang, Meihua, Wang, Quan, Rao, Zihe, Gong, Peng
Publicado 2021

Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL(pro) substrate degradome

por Pablos, Isabel, Machado, Yoan, de Jesus, Hugo C. Ramos, Mohamud, Yasir, Kappelhoff, Reinhild, Lindskog, Cecilia, Vlok, Marli, Bell, Peter A., Butler, Georgina S., Grin, Peter M., Cao, Quynh T., Nguyen, Jenny P., Solis, Nestor, Abbina, Srinivas, Rut, Wioletta, Vederas, John C., Szekely, Laszlo, Szakos, Attila, Drag, Marcin, Kizhakkedathu, Jayachandran N., Mossman, Karen, Hirota, Jeremy A., Jan, Eric, Luo, Honglin, Banerjee, Arinjay, Overall, Christopher M.
Publicado 2021

Stabilized coronavirus spike stem elicits a broadly protective antibody

por Hsieh, Ching-Lin, Werner, Anne P., Leist, Sarah R., Stevens, Laura J., Falconer, Ester, Goldsmith, Jory A., Chou, Chia-Wei, Abiona, Olubukola M., West, Ande, Westendorf, Kathryn, Muthuraman, Krithika, Fritch, Ethan J., Dinnon, Kenneth H., Schäfer, Alexandra, Denison, Mark R., Chappell, James D., Baric, Ralph S., Graham, Barney S., Corbett, Kizzmekia S., McLellan, Jason S.
Publicado 2021

Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain

por Cerutti, Gabriele, Guo, Yicheng, Wang, Pengfei, Nair, Manoj S., Wang, Maple, Huang, Yaoxing, Yu, Jian, Liu, Lihong, Katsamba, Phinikoula S., Bahna, Fabiana, Reddem, Eswar R., Kwong, Peter D., Ho, David D., Sheng, Zizhang, Shapiro, Lawrence
Publicado 2021

Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome

por Xu, Weifan, Pei, Gaofeng, Liu, Hongrui, Ju, Xiaohui, Wang, Jing, Ding, Qiang, Li, Pilong
Publicado 2021

Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

por Ho, J.J. David, Cunningham, Tyler A., Manara, Paola, Coughlin, Caroline A., Arumov, Artavazd, Roberts, Evan R., Osteen, Ashanti, Kumar, Preet, Bilbao, Daniel, Krieger, Jonathan R., Lee, Stephen, Schatz, Jonathan H.
Publicado 2021

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

por D’Antonio, Matteo, Nguyen, Jennifer P., Arthur, Timothy D., Matsui, Hiroko, D’Antonio-Chronowska, Agnieszka, Frazer, Kelly A.
Publicado 2021

Anti-SARS-CoV-2 antibodies elicited by COVID-19 mRNA vaccine exhibit a unique glycosylation pattern

por Farkash, Inbal, Feferman, Tali, Cohen-Saban, Noy, Avraham, Yahel, Morgenstern, David, Mayuni, Grace, Barth, Natasha, Lustig, Yaniv, Miller, Liron, Shouval, Dror S., Biber, Asaf, Kirgner, Ilya, Levin, Yishai, Dahan, Rony
Publicado 2021

Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding

por Mannar, Dhiraj, Saville, James W., Zhu, Xing, Srivastava, Shanti S., Berezuk, Alison M., Zhou, Steven, Tuttle, Katharine S., Kim, Andrew, Li, Wei, Dimitrov, Dimiter S., Subramaniam, Sriram
Publicado 2021

HLA-A(∗)02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses

por Nesterenko, Pavlo A., McLaughlin, Jami, Tsai, Brandon L., Burton Sojo, Giselle, Cheng, Donghui, Zhao, Daniel, Mao, Zhiyuan, Bangayan, Nathanael J., Obusan, Matthew B., Su, Yapeng, Ng, Rachel H., Chour, William, Xie, Jingyi, Li, Yan-Ruide, Lee, Derek, Noguchi, Miyako, Carmona, Camille, Phillips, John W., Kim, Jocelyn T., Yang, Lili, Heath, James R., Boutros, Paul C., Witte, Owen N.
Publicado 2021

The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance

por Kimura, Izumi, Kosugi, Yusuke, Wu, Jiaqi, Zahradnik, Jiri, Yamasoba, Daichi, Butlertanaka, Erika P., Tanaka, Yuri L., Uriu, Keiya, Liu, Yafei, Morizako, Nanami, Shirakawa, Kotaro, Kazuma, Yasuhiro, Nomura, Ryosuke, Horisawa, Yoshihito, Tokunaga, Kenzo, Ueno, Takamasa, Takaori-Kondo, Akifumi, Schreiber, Gideon, Arase, Hisashi, Motozono, Chihiro, Saito, Akatsuki, Nakagawa, So, Sato, Kei
Publicado 2022