Probing key interactions between SARS-CoV-2 spike and heparan sulfate

por Kearns, Fiona L., Rosenfeld, Mia, Hoon Kim, Sang, Casalino, Lorenzo, Papanikolas, Micah, Simmerling, Carlos, Freeman, Ronit, Amaro, Rommie E.
Publicado 2022

Catalytic function and substrate specificity of alpha and beta coronavirus papain-like proteases: targeting human NL63, SARS-CoV and SARS-CoV-2 (Covid-19) with designed inhibitors

por Chapman, Mackenzie E., Daczkowski, Courtney M., Ghosh, Arun K., Mesecar, Andrew D.
Publicado 2022

Combining sample expansion and light-sheet microscopy for the volumetric imaging of virus-infected cells with superresolution

por Mascheroni, Luca, Scherer, Katharina, Kaminski, Clemens F.
Publicado 2022

Investigating SARS-CoV-2 ORF7a and BST-2 heterodimerization by molecular dynamics simulations

por Hsieh, Min-Kang, Klauda, Jeffery B.
Publicado 2022

Amantadine preferential binding and disordering of phase separated membranes

por Kinnun, Jacob J., Scott, Haden L., Melesse, Michael, Doughty, Benjamin, Labbe, Jesse, Collier, Patrick, Katsaras, John
Publicado 2022

Computational studies of the dynamics of SARS-CoV-2 spike, membrane, and nucleocapsid proteins

por Dutta, Mandira, Voth, Gregory A.
Publicado 2022

A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions

por Bauer, Magnus S., Gruber, Sophia, Hausch, Adina, Milles, Lukas F., Nicolaus, Thomas, Schendel, Leonard C., López Navajas, Pilar, Procko, Erik, Lietha, Daniel, Bernardi, Rafael C., Lipfert, Jan, Gaub, Hermann E.
Publicado 2022

The roles of glycans in the SARS-CoV-2 spike protein

por Casalino, Lorenzo, Amaro, Rommie E.
Publicado 2022

SARS-CoV-2 S1 spike protein peptides inhibit alpha 7 nAChRs and are counteracted by a PAM at alpha 7

por Farley, Joseph, Anderson, Jonathan B.
Publicado 2022

Changes in the receptor-binding interface may cause immune evasion by the SARS-CoV-2 delta variant b.1.617.2

por Baral, Prabin, Bhattarai, Nisha, Lokman Hossen, Md, Stebliankin, Vitalii, Gerstman, Bernard S., Narasimhan, Giri, Chapagain, Prem P.
Publicado 2022

SARS-CoV-2 antibodies specific to the mesa and inner side of spike protein receptor binding domain maintain high affinities for both D614G and b.1.351 variants

por Li, Kan, Huntwork, Richard H.C., Horn, Gillian Q., Feeney, Elizabeth, Hastie, Kathryn M., Li, Haoyang, Rayaprolu, Vamseedhar, Olmedillas, Olmedillas, Schendel, Sharon L., Heise, Mark, Baric, Ralph S., Alam, S. Munir, Ollmann Saphire, Erica, Tomaras, Georgia D., Dennison, S. Moses
Publicado 2022

The SARS-CoV-2 spike protein reversibly samples an open-trimer conformation exposing novel epitopes

por Shoemaker, Sophie R., Costello, Shawn M., Hobbs, Helen T., Nguyen, Annalee W., Hsieh, Ching-Lin, Maynard, Jennifer A., McLellan, Jason S., Pak, John E., Marqusee, Susan
Publicado 2022

Structural dynamic changes in the SARS-CoV and SARS-CoV-2 S spike assemblies upon ACE2 activation

por Chen, Chengbo, Munro, James B., Lee, Kelly K.
Publicado 2022

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA

por Jack, Amanda, Ferro, Luke, Trnka, Michael J., Wehri, Eddie, Nadgir, Amrut, Nguyenla, Xammy, Fox, Douglas, Costa, Katelyn, Stanley, Sarah, Schaletzky, Julia, Yildiz, Ahmet
Publicado 2022

Impact of mutations near the SARS-CoV-2 furin-cleavage site on viral infectivity

por Nguyen, Kien, Chakraborty, Srirupa, Manrique, Pedro D., Korber, Bette, Gnanakaran, S.
Publicado 2022

Single molecule activity assay for SARS-CoV-2 RNA dependent RNA polymerase

por Chung, SangYoon, Alhadid, Yazan, Segal, Maya, Lee, Jookyung, Borukhov, Sergei, Weiss, Shimon
Publicado 2022

Unraveling SARS-CoV-2 spike protein activation pathway reveals unprecedented cryptic pockets

por Dokainish, Hisham M., Re, Suyong, Mori, Takaharu, Kobayashi, Chigusa, Jung, Jaewoon, Sugita, Yuji
Publicado 2022

Host cell membrane capture by the SARS-CoV-2 spike protein fusion intermediate

por Su, Rui, Zeng, Jin, O'Shaughnessy, Ben
Publicado 2022

Comparing structural ensembles with DiffNets helps explain the activation mechanism of the SARS-CoV-2 protein NSP16

por Ward, Michael D.
Publicado 2022

The discovery of antivirals and novel targets for SARS-CoV-2 and EV-A71

por Haddad, Christina, Tolbert, Blanton S., Hargrove, Amanda E., Brewer, Gary, Li, Mei-Ling
Publicado 2022