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  1. 309241
    “…The purpose of this study was to determine the magnitude of interindividual variability in response to two nutrition supplementation interventions for sarcopenia and metabolic health, after accounting for sources of variability not attributable to supplementation. METHODS: A 24 week, randomized, double‐blind, placebo‐controlled trial tested the impact of leucine‐enriched protein (LEU‐PRO), LEU‐PRO plus long‐chain n‐3 PUFA (LEU‐PRO+n‐3) or control (CON) supplementation in older adults (n = 83, 71 ± 6 years) at risk of sarcopenia. …”
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    Interindividual variability in response to protein and fish oil supplementation in older adults: a randomized controlled trial
  2. 309242
    “…Secondary outcomes included QoR-40 and mean pain VAS at days 0 (evening of surgery), 1, 2, and 3; cumulative opioid consumption for 72 hours; functional outcomes and quality of life at 6 weeks, 6 months, and 1 year; and cost-effectiveness for 1 year. …”
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    Efficacy of Liposomal Bupivacaine and Bupivacaine Hydrochloride vs Bupivacaine Hydrochloride Alone as a Periarticular Anesthetic for Patients Undergoing Knee Replacement: A Randomized Clinical Trial
  3. 309243
    “…This procedure has been performed by developing a two-week protocol and employing Shh and RA. The miRNA profile analysis showed a significant up-regulation in the expression of some miRs involved in neuron differentiation and motor neuron maturation. …”
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    Large-scale analysis of MicroRNA expression in motor neuron-like cells derived from human umbilical cord blood mesenchymal stem cells
  4. 309244
    “…Moreover, the cattle learned to avoid the virtual border and respond to auditory cues, where the cows received significantly more auditory warning and electric impulses per week throughout the first 14 days than the remaining 125 days (p < 0.001). …”
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    Is Virtual Fencing an Effective Way of Enclosing Cattle? Personality, Herd Behaviour and Welfare
  5. 309245
    “…METHODS: This randomized controlled trial evaluated a 12-week, web-based, automated self-help intervention for fertility-related distress following cancer—Fex-Can Fertility. …”
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    Efficacy of a Web-Based Psychoeducational Intervention for Young Adults With Fertility-Related Distress Following Cancer (Fex-Can): Randomized Controlled Trial
  6. 309246
    “…MAIN EXPOSURE: A healthy lifestyle score was developed based on five modifiable lifestyle factors: a diet for brain health (Mediterranean-DASH Diet Intervention for Neurodegenerative Delay—MIND diet score in upper 40% of cohort distribution), late life cognitive activities (composite score in upper 40%), moderate or vigorous physical activity (≥150 min/week), no smoking, and light to moderate alcohol consumption (women 1-15 g/day; men 1-30 g/day). …”
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    Healthy lifestyle and life expectancy with and without Alzheimer’s dementia: population based cohort study
  7. 309247
    “…We examined whether a 5-week training program that primarily targets the storage component of working memory (Cogmed RM, adaptive) could improve cognition, speech-in-noise perception and self-reported hearing in a randomized controlled trial of adult hearing aid users with mild to moderate hearing loss, compared with an active control (Cogmed RM, nonadaptive) group of adults from the same population. …”
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    Cogmed Training Does Not Generalize to Real-World Benefits for Adult Hearing Aid Users: Results of a Blinded, Active-Controlled Randomized Trial
  8. 309248
    “…Male C57BL/6 mice were randomly divided into five groups (n = 10, each) and treated for 8 weeks as follows: the control diet-fed group (pair-fed), ethanol diet-fed group (EtOH-fed), QGHXR group (EtOH-fed + QGHXR), Qinggan recipe group (EtOH-fed + QGR), and Huoxue recipe group (EtOH-fed + HXR). …”
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    Qinggan Huoxue Recipe Alleviates Alcoholic Liver Injury by Suppressing Endoplasmic Reticulum Stress Through LXR-LPCAT3
  9. 309249
    por Lu, Zhihao, Wang, Junye, Shu, Yongqian, Liu, Lianke, Kong, Li, Yang, Lei, Wang, Buhai, Sun, Guogui, Ji, Yinghua, Cao, Guochun, Liu, Hu, Cui, Tongjian, Li, Na, Qiu, Wensheng, Li, Gaofeng, Hou, Xinfang, Luo, Hui, Xue, Liying, Zhang, Yanqiao, Yue, Wenbin, Liu, Zheng, Wang, Xiuwen, Gao, Shegan, Pan, Yueyin, Galais, Marie-Pierre, Zaanan, Aziz, Ma, Zhuo, Li, Haoyu, Wang, Yan, Shen, Lin, Pan, Zhanyu, Zhang, Shuqun, Lin, Gen, Xie, Yanru, Li, Tao, Ren, Tiejun, Li, Weidong, Gu, Kangsheng, Wang, Shoufeng, He, Wei, Xia, Bing, Fan, Yun, Liang, Jun, Zhao, Kuaile, Pan, Hongming, Xu, Nong, Cheng, Ying, Gao, Quanli, Sun, Ping, Zang, Aimin, Zheng, Anping, Luo, Zhiguo, Liu, Tianshu, Ding, Shubo, Xu, Tianwen, Li, Wei, Liu, Fang, Cang, Shundong, Wang, Junsheng, Lin, Xiaoyan, Jiang, Da, Mao, Rui, Ma, Dong, Liu, Yunpeng, Tao, Min, Tang, Yong, Chen, Xi, Chen, Ping, Feng, Guosheng, Yang, Zhenzhou, Zhang, Guifang, Zhang, Xuebang, Huang, Yong, Lee, Fa-Chyi, Dean, Andrew, El Hajbi, Farid, Ghiringhelli, François, Borg, Christophe, Tougeron, David, Dahan, Laetitia, Pernot, Simon, Rivera, Fernando, Pazo Cid, Roberto Antonio, Vazquez Rivera, Maria Francisca
    Publicado 2022
    “…INTERVENTION: Participants were randomised 1:1 to receive sintilimab or placebo (3 mg/kg in patients weighing <60 kg or 200 mg in patients weighing ≥60 kg) in combination with cisplatin 75 mg/m(2) plus paclitaxel 175 mg/m(2) every three weeks. The trial was amended to allow investigators to choose the chemotherapy regimen: cisplatin plus paclitaxel or cisplatin plus 5-fluorouracil (800 mg/m(2) continuous infusion on days 1-5). …”
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    Sintilimab versus placebo in combination with chemotherapy as first line treatment for locally advanced or metastatic oesophageal squamous cell carcinoma (ORIENT-15): multicentre, randomised, double blind, phase 3 trial
  10. 309250
    “…The mental health questions provided a sample size of 432 642 valid responses, with an average of 14 918 responses every 2 weeks. To investigate how policy stringency was associated with mental health, we considered two potential mediators: observed physical distancing and perceptions of the government's handling of the pandemic. …”
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    Policy stringency and mental health during the COVID-19 pandemic: a longitudinal analysis of data from 15 countries
  11. 309251
    “…However, during AKT/mTOR treatment, outgrowth of therapy-resistant tumors was observed in all mice analyzed within a few weeks. Resistance was associated in most cases with restoration of AKT signaling in the tumors, intrahepatic metastases and distant metastases. …”
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    Combined Targeting of AKT and mTOR Inhibits Tumor Formation of EpCAM(+) and CD90(+) Human Hepatocellular Carcinoma Cells in an Orthotopic Mouse Model
  12. 309252
    “…METHODS: A systematic search of YouTube videos was conducted over the course of 1 week in April 2020 using the following keywords: “gestational diabetes,” “gestational diabetes management,” “gestational diabetes treatment,” and “pregnancy and diabetes.” …”
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    Content Quality of YouTube Videos About Gestational Diabetes: Systematic Evaluation
  13. 309253
    “…We tested the feasibility of remotely delivering the intervention with older adults in a 6-week trial. Data collection involved assessment of PA through accelerometery and activity tracker, self-reported mood and mental well-being through ecological momentary assessment, and contextual information on PA through voice memos. …”
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    A Personalized Smartphone-Delivered Just-in-time Adaptive Intervention (JitaBug) to Increase Physical Activity in Older Adults: Mixed Methods Feasibility Study
  14. 309254
    “…Secondary plant metabolites and, in particular, some phenolic compounds are known to have a strong allelopathic effect on weed growth. In this study we investigated whether phenolic acids (chlorogenic acid, caffeic acid, ferulic acid, gallic acid, protocatechuic acid, p-hydroxybenzoic acid, syringic acid, vanillic acid, and p-coumaric acid) can inhibit the early growth of A. artemisiifolia. …”
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    Selected Phenolic Acids Inhibit the Initial Growth of Ambrosia artemisiifolia L.
  15. 309255
    “…He had recently been admitted at an outside facility for hypercalcemia, which had been managed with denosumab (120 mg subcutaneously) over the previous four weeks. He was admitted from the ED with a serum calcium of 14.6 mg/dL, potassium of 2.9 mmol/L, and phosphate of 1.2 mg/dL; ionized calcium was elevated at 8.0 mg/dL. …”
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    Neuroendocrine Carcinoma as a Cause of Humoral Hypercalcemia of Malignancy: A Case of a Patient With Elevated Parathyroid Hormone-Related Protein
  16. 309256
    “…The fathers (with the mothers) of the intervention group were educated using individual face-to-face education and counseling, in two sessions, with the duration of about 40 min and one-week interval, whereas, the fathers of the control group did not receive any education and only mothers were educated with the same instruction. …”
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    Educating fathers to improve exclusive breastfeeding practices: a randomized controlled trial
  17. 309257
    “…Remaining questions were answered and virtual or telephone follow-up was scheduled. RESULTS: Within 7 weeks of closure, we pivoted to offer our Sexual Health Clinic virtually. …”
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    Virtual Intracavernosal Injection Training During the COVID Pandemic
  18. 309258
    “…Self-reported behavioural outcomes were assessed by a questionnaire pre-intervention (T0, n = 564) and at 2–4 weeks follow-up (T2, n = 493). Psychological outcomes were assessed post-intervention (T1, n = 564) and at follow-up. …”
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    Promoting an active choice among physically inactive adults: a randomised web-based four-arm experiment
  19. 309259
    por Lyu, Xiuhong, Miskovsky, John
    Publicado 2022
    “…The patient is a 41-year-old Caucasian male with severe alcohol abuse who presented with complaints of diffuse yellowish discoloration of skin, fatigue, and "feeling not like himself” for six weeks. A review of systems revealed mild exertional dyspnea and bilateral lower extremity swelling. …”
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    Detecting Concealing Heart Failure in a Young Alcohol-Related Liver Failure Patient Using the Most Basic Pathophysiological Principle
  20. 309260
    “…Background Coronavirus disease 2019 (COVID-19) patients with persistent symptoms for at least four weeks in spite of being reverse transcriptase-polymerase chain reaction (RTPCR) negative for COVID infection are defined as long COVID (wherein pulmonary involvement is seen in a significant proportion of cases). …”
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    The Microbial Profile and Resistance Pattern of Pathogens Isolated From Long COVID Pneumonia Patients and Their Correlation to Clinical Outcome: Our Experience From a Tertiary Care Hospital
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