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  1. 310861
    por Menon, Trisha, Xie, Yan Yan, Wang, Ally
    Publicado 2023
    “…Despite significant improvements in TSH values (from 857 to 67 uIU/L), FT4 (from <0.1 to 1.2 ng/dL), and TT3 (from < 20 to 60 ng/dL), the patient’s cardiac function did not improve and he underwent successful orthotopic heart transplantation two weeks after initial presentation. A cardiac biopsy demonstrated cardiomegaly with left ventricular hypertrophy, subendocardial fibrosis, and patent arteries, without other etiologies of heart failure. …”
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  2. 310862
    “…CGM revealed an average glucose of 192 mg/dL, TIR 71%, above target 24%, and below target 5%. Two weeks later, patient developed bilateral white-pale cold hands, weight gain, fatigue, bloating, constipation, and liver dysfunction with transaminase increasing from baseline ALT 68 U/L, AST 82 U/L, bilirubin 0.5 U/L, to AST 305 U/L, ALT 206 U/L, and bilirubin 1.1 U/L. …”
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  3. 310863
    “…Type 2 diabetes (T2D) was induced in skeletally mature male C57BL/6J mice by high fat diet combined with streptozotocin; and, after established diabetes, mice were treated for 4 weeks with the bone anabolic agents. At the end of the study, T2D mice exhibited decreased total (−5%), femoral (−7%) and spinal (−11%) BMD vs nondiabetic mice. …”
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  4. 310864
    “…Subsequent pituitary MRI showed pituitary intraglandular abscess with a 15% decrease.The patient was discharged six weeks later with prednisone, levothyroxine, somatropin and testosterone, as well as doxycycline and rifampin for another 4 months. …”
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  5. 310865
    “…She required multiple administrations of pamidronate or zoledronic acid every 4-6 weeks. She was started on cinacalcet without substantial effect on hypercalcemia or need for bisphosphonate. …”
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  6. 310866
    “…The patient became hypocalcemic within three weeks of initiation of chemotherapy, and he was started on calcium supplementation without improvement. …”
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  7. 310867
    “…Case #3: 48-year-old male with central hypogonadism currently taking testosterone 100 mg IM every week. Evaluation for central hypogonadism was unrevealing for pituitary lesion. …”
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  8. 310868
    “…Male and female rat pups were injected, on postnatal day 1, subcutaneously with 0.3 mg EB via microsphere that was designed to release EB for 2 weeks; unexposed age matching pups were used as controls (n=6-7/group). …”
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  9. 310869
    “…Her symptoms and sixth nerve palsy resolved after surgery, and she was discharged with hormone replacements and a 6-week course of ceftriaxone. Conclusion: While other Enterobacteriaceae have previously been isolated from pituitary abscesses (including E. coli, Citrobacter, Salmonella, Proteus and Klebsiella), our case demonstrates, to the best of our knowledge, the first case of Serratia isolated from a pituitary abscess. …”
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  10. 310870
    por Davis, Adam N, Elshimy, Ghada
    Publicado 2023
    “…Case: A 69-year-old female with stage IV choroidal melanoma presented to the ED on 7/12/22 with a sudden new onset headache for one week. CT head without contrast was unremarkable, and she was discharged home. …”
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  11. 310871
    “…Patient was subsequently asked to stop all over the counter supplement medications and a DHEA-s level was checked about 6 weeks and was markedly reduced to 435 ug/dL. TSH and free t4 improved to 0.789 IU/mL and free t4 1.43 ng/dL respectively. …”
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  12. 310872
    “…She was diagnosed with Graves’ disease, kept on Methimazole 10mg/day. 2 weeks later, she presented to the ED after syncope at home. …”
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  13. 310873
    “…Glucose ranged between 160-300 mg/dL without any hypoglycemia. On week 4 of alpelisib, plasma glucose was 340 mg/dL, proinsulin >700 pmol/L, insulin 181 uIU/mL, and C-peptide 20.2 ng/mL. …”
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  14. 310874
    “…Methods: PubMed, Cochrane and EMBASE were systematically searched in October 2022 to include randomized controlled studies (RCTs) comparing CL systems (automated pancreas, hybrid CL and advanced hybrid CL) versus SC (daily insulin injections, sensor augmented pump and continuous glucose monitoring) with at least 12 weeks of duration. Outcomes assessed were percentage time in range (% TIR) 70-180mg/dL and change in HbA1c. …”
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  15. 310875
    “…The study was prospective and double blind, participants consuming 150 mg of capsuled GA daily for 2 weeks (n= 62) or placebo (n=63). Highly selective and sensitive validated inhouse LC-MS/MS method, able to measure both serum and urine samples, was used to quantify free cortisol and cortisone. …”
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  16. 310876
    “…Using a well-established PCOS model of hyperandrogenemia we aim to test the hypothesis that androgens cause splenic dysregulations that are exacerbated by obesity. Methods: Three-week-old female mice were treated with the androgen dihydrotestosterone (DHT, 8 mg, s.c) or vehicle. …”
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  17. 310877
    “…Methods: Animal study: Continuous subcutaneous PP infusion for four weeks in a high fat diet mouse model; retinal mRNA obtained using Laser Capture Microdissection and submitted for Ingenuity Pathway analysis. …”
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  18. 310878
    “…In the current study, we investigated the potential of LEAP2 to protect against insulin-induced-hypoglycemia and counteract the effects of ghrelin deletion during the hypoglycemic clamp. Methods: Eight-ten week-old male wild-type (WT), Ghrelin-KO, LEAP2-KO, and LEAP2/Ghrelin-doubleKO (lacking both ghrelin and LEAP2 ) littermates were used for this study (n=7-10 per genotype). …”
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  19. 310879
    “…Blood work revealed elevated plasma normetanephrine (NM) 3543 pg/mL (normal 0- 145) and metanephrine (MN) 871 pg/mL (normal 0-62). (18)F-FDG PET/CT showed a left adrenal mass without abnormal FDG activity. (68)Ga-DOTATATE PET/CT was compatible with left PCC (SUVmax 28). (18)F-DOPA PET/CT showed left PCC and a small retroperitoneal PGL. Two weeks after initiating phenoxybenzamine, she underwent total left adrenalectomy. …”
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  20. 310880
    por Skariah, Annie M, Porter, Tama
    Publicado 2023
    “…Other labs including autoimmune panel were positive for TSI (2.8 with normal <1.3) and thyroid receptor antibody >40 (<15.5 IU/l) confirming Graves' disease. 4 weeks after starting treatment with methimazole, patient was experiencing episodes of hypoglycemia, related to food intake. …”
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