“…METHODS: 137 patients with CD and mUFC >1.5×upper limit of normal were enrolled into a 48-week (W) core phase that included an 8W double-blind, randomized-withdrawal period for eligible patients. …”
Enlace del recurso
Enlace del recurso

“…Experiments in a tumor xenograft model: AtT-20 cells in Matrigel were injected subcutaneously into BALB/c-nu mice. A week after inoculation, we administered 1.2 mg/kg PD168368 intraperitoneally once daily for 14 days. …”
Enlace del recurso
Enlace del recurso

“…To examine the ability of chronic AZP-3813 treatment to maintain suppression of IGF1 levels, we injected normal, 5-week old (∼150g), male Sprague Dawley rats subcutaneously either with vehicle or with AZP-3813 at doses of either 10 or 30mg/kg QD for 19 days (n=7/group). …”
Enlace del recurso
Enlace del recurso

“…The patient was started on hydrocortisone 50 mg in the morning and 20 mg in the afternoon with outpatient taper two weeks following discharge to prednisone 10 mg daily. …”
Enlace del recurso
Enlace del recurso

“…ACTH level was high at 120pg/mL (5-27), and a repeat in 4 weeks was normal at 11pg/ml. His renin activity was elevated at 71ng/ml/hr (1.5-3.5). …”
Enlace del recurso
Enlace del recurso

“…She had undergone two-gland parathyroidectomy with intraoperative PTH decrease of > 50% and normalization of calcium. However two weeks later, her PTH returned to pre-operative levels (with normal 25(OH)D) and continues to remains elevated. …”
Enlace del recurso
Enlace del recurso

“…CLINICAL CASE: A 21-year-old man presented for evaluation of hyperandrogenism after experiencing progressive loss of posterior patch of hair over 3 weeks. He also endorsed acne, intermittent headaches, striae, and difficulty losing weight for the past 2 years. …”
Enlace del recurso
Enlace del recurso

“…CASE: A 60-year-old man with a history of hypertension and BPH presented to the hospital with two weeks of progressive shortness of breath and dysphagia. …”
Enlace del recurso
Enlace del recurso

“…Significant differences (IG vs CG) were also observed for frequency intakes of whole grain products (+1. 0 vs +0. 04/day, p<0. 01) and dairy products (+0.5 vs -0.2/day, p<0. 01) as well as in the percentage of active women (>3 kcal/kg/day: +14.2% vs +2.3%, p=0. 03) and the time spent in sedentary behaviours (-6.7 vs -0.1 h/week, p<0. 01). Distance covered during the 6-minute walk test tended to increase more in IG vs CG (+28.8 vs +5.5 metres, p=0. 05). …”
Enlace del recurso
Enlace del recurso

“…Youth were treated with immediate release metformin dosed twice daily for at least 6 weeks. Pill diaries and pill counts were conducted to assess adherence. …”
Enlace del recurso
Enlace del recurso

“…Growth hormone was trialed for 2 weeks, but he developed acute pancreatitis, so it was discontinued. …”
Enlace del recurso
Enlace del recurso

“…Clinical case: A 60-years old woman presented with a 5-week history of left sided abdominal lump. Her history is significant for NF-1, flank surgery age 5 and hypertension managed by amlodipine. …”
Enlace del recurso
Enlace del recurso

“…She stopped fluticasone and several days later repeated urine testing revealing a urine Fluticasone 17β-carboxylic acid level of 96 pg/nL, two weeks later inhaled budesonide was initiated and over the course of three months her ACTH increased from 3.3 to 18.3 to 26.3 (pg/mL) and cortisol rose slightly from 0.9 to 3.2 to 3.7 mcg/dL. …”
Enlace del recurso
Enlace del recurso

“…Pathology revealed a 3.8 cm LF. Six weeks post-operatively, TT and FT normalized to 18 and 3.6 (0.2-5), respectively.Features atypical for PCOS, including presentation outside age 15-25, rapid progression, TT >2× upper limit of normal (ULN), and free androgen index >4× ULN should prompt thorough evaluation. …”
Enlace del recurso
Enlace del recurso

“…Treatment was initiated with metreleptin 5 mg daily SC in Sister A and 3.75 mg SC daily, increasing to 5 mg daily at Week 8 in Sister B. Both remained on therapy throughout the 18 month observational trial without serious adverse effects or clinical evidence of neutralizing antibodies. …”
Enlace del recurso
Enlace del recurso

“…Adequate intake frequency of confectionery (2–4 times/week) was beneficial to their emotions, conduct, and total difficulties and was also beneficial for peer and prosocial behavior for boys (Girls: emotions: p = 0.02, conduct: p = 0.02, hyperactivity: p = 0.4, peer: p = 0.06, total difficulties: p = 0.01, prosocial behavior: p = 0.1; Boys: emotions: p = 0.009, conduct: p = 0.0009, hyperactivity: p = 0.7, peer: p = 0.02: total difficulties: p = 0.003, prosocial behavior: p = 0.0002). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…At outpatient follow up in 3 weeks, free T4 improved to 1.44 ng/dL and TSH decreased to 1.050 uIU/mL. …”
Enlace del recurso
Enlace del recurso

“…CLINICAL CASE: An ex-28 weeks (birth weight 1.35 kg) male infant admitted to the NICU had increased urine output of 6 mL/kg/hr on days of life (DOL) 9-10. …”
Enlace del recurso
Enlace del recurso

“…Repeat TSHrAb was 9.85 U/L (<1U/L) after 3 weeks of steroids. Levothyroxine was stopped to check whether she had recurrence of Graves’ disease. …”
Enlace del recurso
Enlace del recurso

“…Methimazole was held, and labs repeated after a few weeks, did not change significantly. In September 2020, levothyroxine 25 mcg daily, was initiated due to fatigue symptoms and an elevated TSH 10.61 uIU/ml with low FT4 0.8 ng/dl. …”
Enlace del recurso
Enlace del recurso