“…In the context of the skin biopsy results, a provisional diagnosis of systemic medium-vessel vasculitis was made, and steroid therapy commenced with significant subjective improvement, improvement in anaemia and hypoalbuminaemia, and normalisation of CRP. Two weeks after discharge, genetic testing returned with a somatic variant of the UBA1 gene (Met41Leu), revising the diagnosis to VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic Syndrome). …”
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“…Methods and Study design: Secondary analysis of specimens obtained from a single-arm, open-label clinical trial (NCT01378299) on pharmacogenetics of response to T therapy conducted between 2011-2016 N=105 men (40-74 years old), with average morning T <300 ng/dL who were given intramuscular T cypionate 200 mg every 2 weeks for 18 months As earlier results from our lab, effect of T therapy is maximal after 6 months, we chose to study the specimens at baseline (BL) and 6 months (6M). …”
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“…A marrow biopsy couldn’t be pursued as the patient died within a week of hospitalization. An autopsy was not performed as per family’s request. …”
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“…Following feeding for 15 weeks, the serum levels of Homocysteine (Hcy), total cholesterol (TC), and triglyceride (TG) were measured using an automatic biochemical analyzer. …”
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“…Ten (67%) developed recurrence (median 2 episodes, range 1-7) after ≥2 weeks of oral maintenance therapy. Antiviral treatment is shown in Figure 1. …”
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“…When a variant accounted for >50% of sequenced cases, all person-time during that week was assigned to that variant. Effect estimates for each variant wave were calculated using Cox proportional hazards regression models. …”
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“…Following the introduction of pathogen (Day 0) mice were dosed daily vial oral gavage with five unique candidate consortia (DE061, DE456, DE240, DE714, and DE492) as the microbiome intervention or vehicle only for 6 days and fecal titers are monitored for a 3-week period to evaluate pathogen abundance (B,C) The titers of VRE or CR-Kpn were quantified in fecal pellets by plating on selective agar at the indicated time-points. …”
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“…A nasopharyngeal swab, oropharyngeal swab, and 10mL blood were collected at enrollment (V1), 30 days after enrollment (V2), and in the 4 weeks prior to the start of the influenza season(s) for three years after enrollment (1 yr, 2 yr, 3 yr). …”
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“…Edward Hospital COVID admissions & CDC Nowcast variant proportions during January 2022 [Figure: see text] Left: CDC Nowcast showing Omicron accounted for >95% new infections week ending January 8, 2022 , Right: Edward Hospital COVID admissions from 6/2021-6/2022. …”
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“…Efficacy (n=56): The proportion of pts with clinically significant CMV infection (CMV disease/pre-emptive treatment for CMV viremia) through Week 24 post-HCT was similar (25%) to that seen in adults receiving LET in the Phase 3 study (37.5%). …”
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“…In the PHQ-9, the participants reported that they never felt depressed or felt depressed only for 1–3 days in the past week. The mean score for myths 1–6 and 9–10 ranged from 1.15 (SD = 0.36) to 1.29 (SD = 0.46). …”
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“…Data were collected during Personal Social and Health Education lessons across a 2-week period. PARTICIPANTS/MATERIALS, SETTING, METHODS: Four animations on testicular health and fertility, informed by andrologists, academics, designers, boys, and young men, were developed. …”
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“…After 5 days in supplemented medium, the elutriated cells displayed AP and its production was doubled by the addition of BMP2 (1 ng) (P < 0.04). Two weeks later, 30% of the cells were very large and reacted with anti-osteocalcin antibody. …”
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“…Thus the early stages undergo involution in from two to three weeks, while the late stages may require one to two months. …”
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“…With the usual acute, actively progressing infection of from I to 2 weeks duration produced by our strain of Tr. brucei, the drug has a curative range of from 0.2 to 0.35 gm. per kilo of body weight, when administered intravenously in single doses, or from one-third to one-half the minimal lethal dose. …”
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“…The febrile reaction varied in the animals of this series from a severe continuous fever of 104–105°F., lasting 2 to 3 months, in one instance, with a remittence during the 3rd to 5th weeks, to the acute high fever (106°F.) of 1 day's duration in the fatally infected monkey, No. 25. …”
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“…He further produced experimental arthritis in four rabbits by injection of microbes or a dilute carbolic acid solution. Two to four weeks later, he injected Pregl’s solution and noted resolution. …”
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“…The uncovered wounds of the patients were irradiated two to five times per week for 30 minutes at a standard distance of 25 cm (approximately 140 mW/cm(2) wIRA and approximately 45 mW/cm(2) VIS). …”
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“…The control period for the total colony count was 4 weeks (8 samples/unit). The subsequent application phase of the ActiDes-Blue procedure was 6 months (31 samples/unit). …”
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“…All patients had been HER2- positive by local pathology assessment and had received 24 to 36 weeks of neoadjuvant trastuzumab plus an anthracycline/taxane-based chemotherapy. …”
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