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201por Alqarni, Mohammed Hamed, Foudah, Ahmed Ibrahim, Muharram, Magdy Mohamed, Labrou, Nikolaos E.“…Glutathione transferases (GSTs) are a family of Phase II detoxification enzymes that are involved in the development of the multidrug resistance (MDR) mechanism in cancer cells and therefore affect the clinical outcome of cancer chemotherapy. …”
Publicado 2021
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202por Parimbelli, Mauro, Pezzotti, Elena, Negro, Massimo, Calanni, Luca, Allemano, Silvia, Bernardi, Marco, Berardinelli, Angela, D’Antona, GiuseppeEnlace del recurso
Publicado 2021
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203por Alqarni, Mohammed Hamed, Foudah, Ahmed Ibrahim, Muharram, Magdy Mohamed, Labrou, Nikolaos E.“…Human glutathione transferase A1-1 (hGSTA1-1) contributes to developing resistance to anticancer drugs and, therefore, is promising in terms of drug-design targets for coping with this phenomenon. …”
Publicado 2021
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204por Kalirawna, Teja Ram, Rohilla, Jitendra, Bairwa, Shyam Sunder, Gothwal, Sunil Kumar, Tak, Pinki, Jain, Rajesh“…BACKGROUND: Stroke is responsible for the largest proportion of neurological disorders causing a significant morbidity. Gamma-glutamyl transferase (GGT) enzyme has an active involvement in atherosclerosis through its role in oxidative and inflammatory mechanisms. …”
Publicado 2021
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205por Trobec, Tomaž, Sepčić, Kristina, Žužek, Monika Cecilija, Kladnik, Jerneja, Podjed, Nina, Cardoso Páscoa, Catarina, Turel, Iztok, Frangež, Robert“…A library of organoruthenium(II) complexes was prepared to investigate the influence of their structural elements on inhibition of ChEs, and on another pharmacologically important group of enzymes, glutathione S-transferases (GSTs). Two groups of organoruthenium(II) compounds were considered: (i) organoruthenium(II) complexes with p-cymene as an arene ligand, and (ii) organoruthenium(II) carbonyl complexes as CO-releasing molecules. …”
Publicado 2021
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206“…Tipifarnib, a farnesyl transferase inhibitor, is a small molecule drug candidate that has demonstrated promising clinical activity in HRAS-mutant head and neck squamous cell carcinoma (HNSCC). …”
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207“…Gamma-glutamyl transferase (GGT) is a marker of oxidative stress and cholestasis. …”
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208por Lee, AnbokEnlace del recurso
Publicado 2019
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209por Ottavi, Samantha, Scarry, Sarah M., Mosior, John, Ling, Yan, Roberts, Julia, Singh, Amrita, Zhang, David, Goullieux, Laurent, Roubert, Christine, Bacqué, Eric, Lagiakos, H. Rachel, Vendome, Jeremie, Moraca, Francesca, Li, Kelin, Perkowski, Andrew J., Ramesh, Remya, Bowler, Matthew M., Tracy, William, Feher, Victoria A., Sacchettini, James C., Gold, Ben S., Nathan, Carl F., Aubé, Jeffrey“…[Image: see text] A newly validated target for tuberculosis treatment is phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. …”
Publicado 2022
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210por Kim, Yun Gi, Han, Kyungdo, Jeong, Joo Hee, Roh, Seung-Young, Choi, Yun Young, Min, Kyongjin, Shim, Jaemin, Choi, Jong-Il, Kim, Young-Hoon“…We aimed to determine whether metabolic syndrome and gamma-glutamyl transferase (ɣ-GTP), including their temporal changes, are associated with the risk of SCD. …”
Publicado 2022
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211Glutathione-S-Transferases as Potential Targets for Modulation of Nitric Oxide-Mediated Vasodilation“…Glutathione-S-transferases (GSTs) are highly promiscuous in terms of their interactions with multiple proteins, leading to various functions. …”
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212“…Human Carnitine Acetyl Transferase (hCAT) reversibly catalyzes the transfer of the acetyl-moiety from acetyl-CoA to L-carnitine, modulating the acetyl-CoA/CoA ratio in mitochondria. …”
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213por Simic, Petar, Pljesa, Igor, Nejkovic, Lazar, Jerotic, Djurdja, Coric, Vesna, Stulic, Jelena, Kokosar, Nenad, Popov, Dunja, Savic-Radojevic, Ana, Pazin, Vladimir, Pljesa-Ercegovac, Marija“…Chemotherapy resistance of ovarian cancer, regarded as the most lethal malignant gynecological disease, can be explained by several mechanisms, including increased activity of efflux transporters leading to decreased intracellular drug accumulation, increased efflux of the therapeutic agents from the cell by multidrug-resistance-associated protein (MRP1), enhanced DNA repair, altered apoptotic pathways, silencing of a number of genes, as well as drug inactivation, especially by glutathione transferase P1 (GSTP1). Indeed, GSTP1 has been recognized as the major enzyme responsible for the conversion of drugs most commonly used to treat metastatic ovarian cancer into less effective forms. …”
Publicado 2022
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214Glutathione S-transferases Control astrocyte activation and neuronal health during neuroinflammation“…Glutathione S-transferases (GST) are phase II detoxification enzymes of xenobiotic metabolism and readily expressed in the brain. …”
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215“…Comparative studies designed to investigate the role of glutathione S-transferase (GST) activity on the enzyme catalyzed trapping of aflatoxin B(1)-8,9-epoxide (AFBO) with glutathione, and the relationship with aflatoxin B(1) (AFB(1)) resistance have not been conducted in poultry. …”
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216por Abeywansha, Thilini, Huang, Wei, Ye, Xuan, Nawrocki, Allison, Lan, Xin, Jankowsky, Eckhard, Taylor, Derek J., Zhang, Yi“…Arginyl-tRNA-protein transferase 1 (ATE1) is a master regulator of protein homeostasis, stress response, cytoskeleton maintenance, and cell migration. …”
Publicado 2023
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217“…This modification is generally catalyzed by three types of prenyl transferases, which include farnesyl transferase (FT), geranylgeranyl transferase (GGT-1) and Rab geranylgeranyl transferase (GGT-2). …”
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218por Zhang, Jie, Ye, Zhi-wei, Bräutigam, Lars, Chakraborty, Paramita, Luo, Zhenwu, Culpepper, John, Aslam, Muhammad, Zhang, Leilei, Johansson, Katarina, Haeggström, Jesper Z., Xu, Jianqiang, Olsson, Magnus, Townsend, Danyelle M., Mehrotra, Shikhar, Morgenstern, Ralf, Tew, Kenneth D.“…We identify a role for microsomal glutathione transferase 1 (MGST1) in biosynthetic pathways for melanin and as a determinant of tumor progression. …”
Publicado 2023
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219por Ye, Qinglin, Xu, Guiling, Huang, Haizhen, Pang, Shuting, Xie, Boji, Feng, Bingmei, Liang, Peng, Qin, Yijie, Li, Siji, Luo, Yin, Xue, Chao, Li, WeiEnlace del recurso
Publicado 2023
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220por Đukić, Nina, Strømland, Øyvind, Elsborg, Jonas Damgaard, Munnur, Deeksha, Zhu, Kang, Schuller, Marion, Chatrin, Chatrin, Kar, Pulak, Duma, Lena, Suyari, Osamu, Rack, Johannes Gregor Matthias, Baretić, Domagoj, Crudgington, Dorian Richard Kenneth, Groslambert, Joséphine, Fowler, Gerissa, Wijngaarden, Sven, Prokhorova, Evgeniia, Rehwinkel, Jan, Schüler, Herwig, Filippov, Dmitri V., Sanyal, Sumana, Ahel, Dragana, Nielsen, Michael L, Smith, Rebecca, Ahel, Ivan“…PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity, transcription, and DNA replication stress management. …”
Publicado 2023
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