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321“…BACKGROUND: PPAT (phosphoribosyl pyrophosphate amido transferase) catalyzes the first committed step of de novo purine biosynthesis and is a key regulatory point in the biosynthesis of nascent purine nucleotides. …”
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322por Perperopoulou, Fereniki, Poudel, Nirmal, Papageorgiou, Anastassios C., Ataya, Farid S., Labrou, Nikolaos E.“…Glutathione transferases (GSTs; EC. 2.5.1.18) are a large family of multifunctional enzymes that play crucial roles in the metabolism and inactivation of a broad range of xenobiotic compounds. …”
Publicado 2022
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323por Campione, Elena, Mazzilli, Sara, Di Prete, Monia, Dattola, Annunziata, Cosio, Terenzio, Lettieri Barbato, Daniele, Costanza, Gaetana, Lanna, Caterina, Manfreda, Valeria, Gaeta Schumak, Ruslana, Prignano, Francesca, Coniglione, Filadelfo, Ciprani, Fabrizio, Aquilano, Katia, Bianchi, Luca“…Dimethyl fumarate depletes glutathione-S transferase by formation of covalently linked conjugates. …”
Publicado 2022
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324“…SIMPLE SUMMARY: Sitophilus zeamais is a worldwide pest that destroys many grain products, causing a loss of cereal quality and quantity resulting from its metabolites and behavior. Glutathione S-transferases (GSTs), as a group of odorant-degrading enzymes (ODEs), play an important role in degrading xenobiotic odorant molecules in insect olfactory sensing systems. …”
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325por de Oliveira, Maycon Vinicius Damasceno, Furtado, Renan Machado, da Costa, Kauê S., Vakal, Serhii, Lima, Anderson H.“…The UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) enzyme is responsible for transferring the enolpyruvate group from phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine (UNAG) to form UDP-N-acetylglucosamine enolpyruvate (EP-UNAG). …”
Publicado 2022
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326por Zhang, Zhanhu, Xu, Lili, Huang, Lin, Li, Tianqi, Wang, Jane Y., Ma, Chunhua, Bian, Xiaoyun, Ren, Xiaoyan, Li, Haibo, Wang, Xingmin“…Glutathione S-transferase alpha 4 (GSTA4) is a phase II detoxifying enzyme that is overexpressed in colorectal cancer (CRC) and regulated by the oncogenic transcription factor AP-1. …”
Publicado 2022
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327“…Protein O-GlcNAcylation is a dynamic posttranslational modification that is catalyzed by the enzyme O-GlcNAc transferase (OGT) and is essential for neurodevelopment and postnatal neuronal function. …”
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328por Xia, Mingyue, Wang, Shuyan, Qi, Yannan, Long, Kaili, Li, Enjie, He, Lingfeng, Pan, Feiyan, Guo, Zhigang, Hu, Zhigang“…The expression of O-GlcNAc transferase (OGT) and its catalytic product, O-GlcNAcylation (O-GlcNAc), are elevated in many types of cancers, including prostate cancer (PC). …”
Publicado 2022
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329por Carlson, Hans K., Youngblut, Matthew D., Redford, Steven A., Williamson, Adam J., Coates, John D.“…Different oxyanions vary widely in their inhibitory potency and mechanism of inhibition, but current evidence suggests that the sulfate adenylyl transferase/ATP sulfurylase (Sat) enzyme is an important target. …”
Publicado 2021
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330“…BACKGROUND: Glutathione S-transferase (GST) in eukaryotic organisms has multiple functions such as detoxifying endogenous/exogenous harmful substances to protect cells from oxidative damage, participating in sterol synthesis and metabolism, and regulating signaling pathways. …”
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331por Zhang, Songya, Fan, Shuai, Zhu, Jing, Zhou, Liying, Yan, Xiaohui, Yang, Zhaoyong, Si, Tong, Liu, Tao“…Phosphopantetheinyl transferases (PPTases) play important roles in activating apo-acyl carrier proteins (apo-ACPs) and apo-peptidyl carrier proteins (apo-PCPs) in both primary and secondary metabolism. …”
Publicado 2022
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332Hypoxanthine guanine phosphoribosyl transferases SmHGPRTases functional roles in Schistosoma mansonipor Batista, Izabella Cristina Andrade, Gava, Sandra Grossi, Tavares, Naiara Clemente, Calzavara-Silva, Carlos Eduardo, Mourão, Marina Moraes“…In addition, early studies demonstrated that Smp38 MAPK regulates the expression of a large set of genes, among them the hypoxanthine-guanine phosphoribosyl transferase 1 (SmHGPRTase 1, Smp_103560), a key enzyme in the purine salvage pathway that is part of a family comprising five different proteins. …”
Publicado 2022
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333por Sha, Huanhuan, Zou, Renrui, Lu, Ya, Gan, Yujie, Ma, Rong, Feng, Jifeng, Chen, Dan“…The vital Glutathione transferase P1 (GSTPi) inhibitor 6‐(7‐nitro‐2,1,3‐benzoxadiazol‐4‐ylthio) hexanol (NBDHEX) has recently shown antitumor activity in various cancers. …”
Publicado 2022
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334por Borges, Dayanne Silva, Vecchi, Lara, Barros, Deysse Carla Tolentino, Arruda, Vinícius Marques, Ferreira, Helen Soares Valença, da Silva, Matheus Fernandes, Guerra, Joyce Ferreira da Costa, Siqueira, Raoni Pais, Araújo, Thaise GonçalvesEnlace del recurso
Publicado 2023
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335por de Obeso Fernández del Valle, Alvaro, Scheckhuber, Christian Quintus, Chavaro-Pérez, David Armando, Ortega-Barragán, Erandi, Maciver, Sutherland K.“…Gene expression during Acanthamoeba encystation showed an upregulation of glutathione S-transferase (GST) genes and other closely related proteins. mRNA sequencing showed GST, and five genes with similar sequences were upregulated after 24 h of inducing encystation. …”
Publicado 2023
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336por He, Jun, Mu, Yi, Liu, Miao, Che, Bang-Wei, Zhang, Wen-Jun, Chen, Ke-Hang, Tang, Kai-Fa“…Male infertility caused by idiopathic oligoasthenospermia (OAT) is known as idiopathic male infertility. Glutathione S-transferase (GST) and fluoride may play important roles in idiopathic male infertility, but their effects are still unknown. …”
Publicado 2022
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337por Scaffa, Polliana Mendes Candia, Kendall, Alexander, Icimoto, Marcelo Yudi, Fugolin, Ana Paula Piovezan, Logan, Matthew G., DeVito-Moraes, Andre G., Lewis, Steven H., Zhang, Hua, Wu, Hui, Pfeifer, Carmem S.Enlace del recurso
Publicado 2023
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338“…Herein, we report the structural mechanism underlying the substrate and catalytic promiscuity of Vibrio dual lipase/transferase (VDLT). Crystal structures of the VDLT from Vibrio alginolyticus (ValDLT) and its fatty acid complexes were solved, revealing prominent structural flexibility. …”
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339por Xia, Mingyue, Wang, Shuyan, Qi, Yannan, Long, Kaili, Li, Enjie, He, Lingfeng, Pan, Feiyan, Guo, Zhigang, Hu, ZhigangEnlace del recurso
Publicado 2023
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340“…Glutathione S-transferase omega 1 (GstO1) is closely associated with various human diseases, including obesity and diabetes, but its functional mechanism is not fully understood. …”
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