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581por Asadi Saatlou, Zahra, Sedaghat, Mohammad Mehdi, Taghilou, Behrooz, Gholizadeh, Saber“…The current study aimed to the detection of three well-known amino acid substitutions (I114T, L119F, and F120L) in the Glutathione S-Transferases epsilon 2 (GSTe2) gene are associated with DDT and organophosphate insecticides resistance in an Anopheles maculipennis population collected from Iran. …”
Publicado 2019
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582por Liu, Weiping, Long, Hongyu, Zhang, Mengqi, Wang, Yanjing, Lu, Qiong, Yuan, Haiyan, Qu, Qiang, Qu, Jian“…Background: The glutathione S-transferase (GST) genes encode enzymes that metabolize carcinogenic compounds, and their variants, GSTP1 (Ile105Val and Ala114Val), GSTT1 (null/present), and GSTM1 (null/present), reduce enzyme activity that may affect the risk of developing cerebral glioma. …”
Publicado 2019
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583“…Carbohydrates are attached and removed in living systems through the action of carbohydrate‐active enzymes such as glycosyl transferases and glycoside hydrolases. The molecules resulting from these enzymes have many important roles in organisms, such as cellular communication, structural support, and energy metabolism. …”
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584por Tam, Benjamin, Sherf, Dror, Cohen, Shira, Eisdorfer, Sarah Adi, Perez, Moshe, Soffer, Adam, Vilenchik, Dan, Akabayov, Sabine Ruth, Wagner, Gerhard, Akabayov, Barak“…We have overcome this in a tractable way by using an RNA segment that represents the peptidyl transferase center as a target. By using a novel combination of NMR transverse relaxation times (T(2)) and computational chemistry approaches, we have obtained improved inhibitors of the Mtb ribosomal PTC. …”
Publicado 2019
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585por Yang, Yunfan, Fu, Minnie, Li, Min-Dian, Zhang, Kaisi, Zhang, Bichen, Wang, Simeng, Liu, Yuyang, Ni, Weiming, Ong, Qunxiang, Mi, Jia, Yang, Xiaoyong“…Nutrient flux into the hexosamine biosynthetic pathway leads to protein posttranslational modification by O-linked β-N-acetylglucosamine (O-GlcNAc) moieties. O-GlcNAc transferase (OGT) is responsible for the addition of GlcNAc moieties to target proteins. …”
Publicado 2020
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586por Al-Madboly, Lamiaa A., Ali, Safaa M., Fakharany, Esmail M. El, Ragab, Amany E., Khedr, Eman G., Elokely, Khaled M.“…More attention has been recently directed toward glutathione peroxidase and s-transferase enzymes because of the great importance they hold with respect to their applications in the pharmaceutical field. …”
Publicado 2020
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587por Zhao, Yun, Dong, Weiqi, Zhu, Yongchao, Allan, Andrew C., Lin‐Wang, Kui, Xu, Changjie“…Expression analysis was conducted on a glutathione S‐transferase gene (PpGST1), and it was found that the expression correlated well with anthocyanin accumulation in peach fruit tissues. …”
Publicado 2019
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589por Lacombe, Amanda Meneses Ferreira, Soares, Iberê Cauduro, Charchar, Helaine da Silva, Brondani, Vânia Balderrama, Neto, João Evangelista Bezerra, Tanno, Fabio, Srougi, Victor, Chambo, José Luiz, de Freitas, Ricardo Miguel Costa, Hoff, Ana Oliveira, Almeida, Madson Q, Zerbini, Maria Claudia Nogueira, Kroiss, Matthias, Fragoso, Maria Candida Barisson Villares“…Mitotane inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells. …”
Publicado 2020
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591por Mørkholt, Anne Skøttrup, Oklinski, Michal Krystian, Larsen, Agnete, Bockermann, Robert, Issazadeh-Navikas, Shohreh, Nieland, Jette Goller Kloth, Kwon, Tae-Hwan, Corthals, Angelique, Nielsen, Søren, Nieland, John Dirk Vestergaard“…Carnitine Palmitoyl Transferase 1 (CPT1) is a rate-limiting enzyme for beta-oxidation of fatty acids in mitochondria. …”
Publicado 2020
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592por Gardiner, John H., Komazin, Gloria, Matsuo, Miki, Cole, Kaitlin, Götz, Friedrich, Meredith, Timothy C.“…The two genes, which we have named the lipoprotein N-acylation transferase system (Lns), bear no resemblance to previously characterized N-terminal Lpp tailoring enzymes. …”
Publicado 2020
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593por Oni, Ebenezer T., Figueredo, Vincent, Aneni, Ehimen, Veladar, Emir, McEvoy, John W., Blaha, Michael J., Blumenthal, Roger S., Conceicao, Raquel D., Carvalho, Jose A.M., Santos, Raul D., Nasir, Khurram“…BACKGROUND: Serum gamma-glutamyl transferase (GGT) is a marker of oxidative stress, associated with increased cardiovascular (CV) risk. …”
Publicado 2020
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594por Sun, Le-Jia, Guan, Ai, Xu, Wei-Yu, Liu, Mei-Xi, Yin, Huan-Huan, Jin, Bao, Xu, Gang, Xie, Fei-Hu, Xu, Hai-Feng, Du, Shun-Da, Xu, Yi-Yao, Zhao, Hai-Tao, Lu, Xin, Sang, Xin-Ting, Yang, Hua-Yu, Mao, Yi-Lei“…BACKGROUND: Gallbladder carcinoma (GBC) carries a poor prognosis and requires a prediction method. Gamma-glutamyl transferase–to–platelet ratio (GPR) is a recently reported cancer prognostic factor. …”
Publicado 2020
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595por Hernández-Rubio, Anna, Sanvisens, Arantza, Bolao, Ferran, Pérez-Mañá, Clara, García-Marchena, Nuria, Fernández-Prendes, Carla, Muñoz, Alvaro, Muga, RobertoEnlace del recurso
Publicado 2020
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596por Hamilton, David J., Ábrányi-Balogh, Péter, Keeley, Aaron, Petri, László, Hrast, Martina, Imre, Tímea, Wijtmans, Maikel, Gobec, Stanislav, de Esch, Iwan J. P., Keserű, György Miklós“…Drug discovery programs against the antibacterial target UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) have already resulted in covalent inhibitors having small three- and five-membered heterocyclic rings. …”
Publicado 2020
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597por Lin, Yuanxiu, Zhang, Lianxi, Zhang, JiaHao, Zhang, Yunting, Wang, Yan, Chen, Qing, Luo, Ya, Zhang, Yong, Li, Mengyao, Wang, Xiaorong, Tang, Haoru“…Previous studies in model and ornamental plants indicated members of the glutathione S-transferase (GST) gene family were involved in vacuolar accumulation of anthocyanins. …”
Publicado 2020
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598por Stuart, Rebekah B., Zwaanswijk, Suzanne, MacKintosh, Neil D., Witikornkul, Boontarikaan, Brophy, Peter M., Morphew, Russell M.“…However, there is limited phase I capacity in adult parasitic helminths with the phase II detoxification system dominated by the soluble glutathione transferase (GST) superfamily. Previous proteomic studies have demonstrated that the levels of Mu class GST from pooled F. hepatica parasites respond under TCBZ-sulphoxide (TCBZ-SO) challenge during in vitro culture ex-host. …”
Publicado 2021
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599por Essawy, Ahmad, Jo, Seokwon, Beetch, Megan, Lockridge, Amber, Gustafson, Eric, Alejandro, Emilyn U.“…The nutrient sensor O-GlcNAc transferase (OGT) catalyzes posttranslational addition of O-GlcNAc onto target proteins, influencing signaling pathways in response to cellular nutrient levels. …”
Publicado 2021
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600por Tan, Zheqiong, Zou, Yaru, Zhu, Man, Luo, Zhenzhao, Wu, Tangwei, Zheng, Chao, Xie, Aqing, Wang, Hui, Fang, Shiqiang, Liu, Shuiyi, Li, Yong, Lu, Zhongxin“…BACKGROUND: Carnitine palmitoyl transferase 1A (CPT1A), the key regulator of fatty acid oxidation, contributes to tumor metastasis and therapeutic resistance. …”
Publicado 2021
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