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641“…SMYD makes up a SET (Su (Var) 3-9, Enhancer-of-zeste and Trithorax) and MYND (Myeloid, Nervy, and DEAF-1) domain containing lysine methyl transferase subfamily that transfers methyl groups from methyl donors onto lysine residues in histones (H3 and H4) and non-histone proteins. …”
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642por Sheikh, Muhammad Abid, Alawathugoda, Thilina T., Vyas, Garima, Emerald, Bright Starling, Ansari, Suraiya A.“…Protein O-GlcNAcylation is catalyzed by the enzyme O-GlcNAc transferase (OGT), an effector of hexosamine biosynthesis pathway that is found to be upregulated in most cancers. …”
Publicado 2023
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643por Erlacher, Matthias D., Lang, Kathrin, Shankaran, Nisha, Wotzel, Brigitte, Hüttenhofer, Alexander, Micura, Ronald, Mankin, Alexander S., Polacek, Norbert“…Here, we employed an in vitro reconstitution system for chemical engineering the peptidyl transferase center by introducing non-natural nucleosides at position A2451. …”
Publicado 2005
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644por Chandramohan, Uma Maheswari“…The active site residues by using the Prothrombin (1A2C), Neutrophil collagenase (1A86), Glutathione S-transferase P(18 GS) protein with ligand 3-Hydroxyflavone, fair binding affinity was found for the Glutathione S-transferase P (18 GS). …”
Publicado 2023
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645por Guengerich, F P, Shimada, T, Raney, K D, Yun, C H, Meyer, D J, Ketterer, B, Harris, T M, Groopman, J D, Kadlubar, F F“…Studies with cytochrome P450 (P450) enzymes and glutathione S-transferases are summarized here, and recent work with pyrrolizidine alkaloids, aflatoxins, 4,4'-methylenebis(2-chloroaniline), and ethyl carbamate is discussed. …”
Publicado 1992
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646“…Ninety-four human non-small cell lung carcinomas (NSCLC) of previously untreated patients were analysed for the presence of P-glycoprotein (P-170) and glutathione S-transferase-pi (GST-pi) by means of immunohistochemistry. …”
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647“…A study involving the measurement of glutathione S-transferase activities and isoenzyme distributions in human ovarian tumours has been carried out. …”
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648“…The effect of inhibitors of nuclear ADP-ribosyl transferase (ADPRT) on the cytotoxicity of melphalan (L-PAM) in the RIF-1 tumour in vivo was investigated. …”
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649“…As many cytotoxic drugs generate both superoxide and hydrogen peroxide, we assessed the relative significance of catalase and the glutathione redox cycle, as well as glutathione S-transferase (GST), in protecting these cells against hydrogen peroxide and epirubicin toxicity. …”
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650Publicado 1978“…Terminal deoxynucleotidyl transferase (TdT) expression in bovine serum albumin (BSA) gradient-fractionated bone marrow cells was examined in NIH Swiss nu/nu and thymectomized C57BL/6 mice. …”
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651
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652por Dosaka-Akita, H, Kinoshita, I, Yamazaki, K, Izumi, H, Itoh, T, Katoh, H, Nishimura, M, Matsuo, K, Yamada, Y, Kohno, K“…N-acetylgalactosaminyl transferase-3 (GalNAc-T3) is an enzyme involved in the initial glycosylation of mucin-type O-linked proteins. …”
Publicado 2002
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653por Ohyama, Tomoko, Verstreken, Patrik, Ly, Cindy V., Rosenmund, Tanja, Rajan, Akhila, Tien, An-Chi, Haueter, Claire, Schulze, Karen L., Bellen, Hugo J.“…In this study, we identify a role for the Drosophila melanogaster palmitoyl transferase Huntingtin-interacting protein 14 (HIP14) in neurotransmitter release. hip14 mutants show exocytic defects at low frequency stimulation and a nearly complete loss of synaptic transmission at higher temperature. …”
Publicado 2007
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654por Sparreboom, A, Kehrer, D F S, Mathijssen, R H J, Xie, R, de Jonge, M J A, de Bruijn, P, Planting, A S T, Eskens, F A L M, Verheij, C, de Heus, G, Klaren, A, Zhang, S, Verhaeghe, T, Palmer, P A, Verweij, J“…The aims of this study were to determine the maximum-tolerated dose (MTD), toxicity profile, and pharmacokinetics of irinotecan given with oral R115777 (tipifarnib), a farnesyl protein transferase inhibitor. Patients were treated with escalating doses of irinotecan with interval-modulated dosing of R115777 (continuously or on days 1–14, and repeated every 21 days). …”
Publicado 2004
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655por Appels, N M G M, Bolijn, M J, Chan, K, Stephens, T C, Hoctin-Boes, G, Middleton, M, Beijnen, J H, de Bono, J S, Harris, A L, Schellens, J H MEnlace del recurso
Publicado 2008
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656por Kim, Soo-Joong, Kim, Myeong-Gon, Kim, Kwon-Sam, Song, Jung-Sang, Yim, Sung-Vin, Chung, Joo-Ho“…Glutathione S-transferase (GST) plays a key role in the detoxification of xenobiotic atherogen generated by smoking. …”
Publicado 2008
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657por Morales, Eva, Sunyer, Jordi, Castro-Giner, Francesc, Estivill, Xavier, Julvez, Jordi, Ribas-Fitó, Nuria, Torrent, Maties, Grimalt, Joan O., de Cid, Rafael“…We hypothesized that genetic variability in glutathione S-transferase (GST) genes (GSTP1, GSTM1, and GSTT1) could influence the effects of prenatal exposure to p,p′-DDT. …”
Publicado 2008
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658por Chirkova, Anna, Erlacher, Matthias D., Clementi, Nina, Zywicki, Marek, Aigner, Michaela, Polacek, Norbert“…Despite the fact that all 23S rRNA nucleotides that build the ribosomal peptidyl transferase ribozyme are universally conserved, standard and atomic mutagenesis studies revealed the nucleobase identities being non-critical for catalysis. …”
Publicado 2010
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659por Morou, Evangelia, Dowd, Andrew J., Rajatileka, Shavanti, Steven, Andrew, Hemingway, Janet, Ranson, Hilary, Paine, Mark, Vontas, John“…The colorimetric assay is based on the specific alkyl transferase activity of Epsilon GSTs for the haloalkene substrate iodoethane, which produces a dark blue colour highly correlated with AaGSTE2-2-overexpression in individual mosquitoes. …”
Publicado 2010
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660por de Medina-Redondo, María, Arnáiz-Pita, Yolanda, Clavaud, Cécile, Fontaine, Thierry, del Rey, Francisco, Latgé, Jean Paul, Vázquez de Aldana, Carlos R.“…Four genes encoding β(1,3)-glucanosyl-transferases -gas1(+), gas2(+), gas4(+) and gas5(+)- are present in S. pombe, although their function has not been analyzed. …”
Publicado 2010
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