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821por Bell, D A, Thompson, C L, Taylor, J, Miller, C R, Perera, F, Hsieh, L L, Lucier, G W“…This study focuses on the polymorphic enzyme glutathione transferase mu (GT mu). Smokers with low lymphocyte GT mu activity are at an approximately 2-fold higher risk for lung cancer and an approximately 3-fold higher risk for stomach and colon adenocarcinomas. …”
Publicado 1992
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823“…We tentatively named this enzyme ThDP adenylyl transferase (EC 2.7.7.65). CONCLUSION: This is the first demonstration of an enzyme activity transferring a nucleotidyl group on thiamine diphosphate to produce AThTP. …”
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824por Linsenmeyer, M. E., Jefferson, S., Wolf, M., Matthews, J. P., Board, P. G., Woodcock, D. M.“…We have quantitated the levels of mRNAs in bone marrow samples from patients with multiple myeloma of the mdr1 gene (responsible for the Multidrug Resistance phenotype) and for two of the glutathione S-transferase gene, GST-2 and GST-3 (which can also inactivate a wide variety of cytotoxic drugs) and examined the relationship between the levels of expression of these genes and response to subsequent chemotherapy. …”
Publicado 1992
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825por Wright, C., Cairns, J., Cantwell, B. J., Cattan, A. R., Hall, A. G., Harris, A. L., Horne, C. H.“…Expression of c-erbB-2 protein and cytosolic glutathione S-transferase (GST) isoenzymes pi, alpha and mu by the primary tumours of these patients was determined immunohistochemically, and correlated with treatment response. …”
Publicado 1992
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826“…A study has been carried out to investigate the cellular distribution and levels of glutathione-S-transferase isoenzymes (GST), acidic (pi), basic (alpha) and neutral (mu), in ovarian tumour biopsies, and to measure GST activity in the same tumour specimens. …”
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827Publicado 1996“…We have previously reported that the genes encoding the glycosyl transferases responsible for the biosynthesis of the variable alpha chain of the LOS of Neisseria gonorrhoeae are located in a locus containing five genes, lgtA, lgtB, lgtC, lgtD, and lgtE. …”
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828por Banerjee, Asesh, Wang, Rong, Supernavage, Sherry L., Ghosh, Salil K., Parker, James, Ganesh, Nisha F., Wang, Peng G., Gulati, Sunita, Rice, Peter A.“…In this report, we describe the cloning and characterization of the GC gene, pilus glycosyl transferase A (pgtA), which encodes the galactosyl transferase that catalyzes the synthesis of this Gal–GlcNAc bond of pilin glycan. …”
Publicado 2002
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829por Goekkurt, E, Hoehn, S, Wolschke, C, Wittmer, C, Stueber, C, Hossfeld, D K, Stoehlmacher, J“…Patients possessing the glutathione S-transferase P1-105 Valine/Valine (GSTP1-105VV) genotype showed a response rate of 67% compared to 21% in patients harbouring at least one GSTP1-105 Isoleucine (GSTP1-105I) allele (P=0.038). …”
Publicado 2006
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830por Khedhaier, A, Remadi, S, Corbex, M, Ahmed, S B, Bouaouina, N, Mestiri, S, Azaiez, R, Helal, A N, Chouchane, L“…Glutathione S-transferase Theta1 and Mu1 (GSTT1 and GSTM1) are involved in the metabolism and detoxification of a wide range of potential environmental carcinogens. …”
Publicado 2003
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831por Nock, Nora L., Bock, Cathryn, Neslund-Dudas, Christine, Beebe-Dimmer, Jennifer, Rundle, Andrew, Tang, Deliang, Jankowski, Michelle, Rybicki, Benjamin A.“…OBJECTIVE: Genetic polymorphisms that modify the detoxifying activity of glutathione S-transferases (GSTs) can affect the level of carcinogenic metabolites created by endogenous steroid hormones and exogenous chemical substances. …”
Publicado 2009
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832por Chen, Yao-Li, Tseng, Hsin-Shun, Kuo, Wu-Hsien, Yang, Shun-Fa, Chen, Dar-Ren, Tsai, Hsiu-Ting“…Phase II enzymes such as glutathione s-transferases (GSTP1, GSTA1) play important roles in protecting cells against damage induced by carcinogens. …”
Publicado 2010
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833por Curtis, Jessica M., Grimsrud, Paul A., Wright, Wendy S., Xu, Xin, Foncea, Rocio E., Graham, David W., Brestoff, Jonathan R., Wiczer, Brian M., Ilkayeva, Olga, Cianflone, Katherine, Muoio, Deborah E., Arriaga, Edgar A., Bernlohr, David A.“…The primary enzymatic method for lipid aldehyde detoxification is via glutathione S-transferase A4 (GSTA4) dependent glutathionylation. …”
Publicado 2010
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834por Khan, Muhammad Imran, Micheal, Shazia, Akhtar, Farah, Ahmed, Waqar, Ijaz, Bushra, Ahmed, Asifa, Qamar, Raheel“…PURPOSE: The aim of the present study was to investigate the association of glutathione S-transferase GSTT1 and GSTM1 genotypes with pseudoexfoliative glaucoma (PEXG) in a group of Pakistani patients. …”
Publicado 2010
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835por Conti, Roberto, Mannucci, Edoardo, Pessotto, Pompeo, Tassoni, Emanuela, Carminati, Paolo, Giannessi, Fabio, Arduini, Arduino“…OBJECTIVE: We have developed a new antihyperglycemic agent (teglicar) through the selective and reversible inhibition of the liver isoform of carnitine palmitoyl-transferase 1 (L-CPT1). RESEARCH DESIGN AND METHODS: Glucose production was investigated in isolated hepatocytes and during pancreatic clamps in healthy rats. …”
Publicado 2011
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836por Hsu, Ling-I, Chen, Wu-Ping, Yang, Tse-Yen, Chen, Yu-Hsin, Lo, Wann-Cheng, Wang, Yuan-Hung, Liao, Ya-Tang, Hsueh, Yu-Mei, Chiou, Hung-Yi, Wu, Meei-Maan, Chen, Chien-JenEnlace del recurso
Publicado 2011
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837por Haghighi, Sassan, Amini, Massoud, Pournaghshband, Zahra, Amini, Peyvand, Hovsepian, Silva“…BACKGROUND: Considering that serum gamma-glutamyl transferase (GGT) activity could reflect several different processes relevant to diabetes pathogenesis and the increasing rate of type 2 diabetes worldwide, the aim of this study was to assess the association between serum GGT concentrations and glucose intolerance, in the first-degree relatives (FDR) of type 2 diabetic patients. …”
Publicado 2011
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838por Sytykiewicz, Hubert“…Furthermore, the effect of juglone-induced oxidative stress on glutathione transferase (GstI) gene expression patterns in maize seedlings was recorded. …”
Publicado 2011
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839por Wiemann, Philipp, Albermann, Sabine, Niehaus, Eva-Maria, Studt, Lena, von Bargen, Katharina W., Brock, Nelson L., Humpf, Hans-Ulrich, Dickschat, Jeroen S., Tudzynski, Bettina“…The key enzymes needed for their production belong to the family of polyketide synthases (PKSs) and non-ribosomal peptide synthases (NRPSs) that are generally known to be post-translationally modified by a Sfp-type 4′phosphopantetheinyl transferase (PPTase). In this study we provide evidence that the F. fujikuroi Sfp-type PPTase FfPpt1 is essentially involved in lysine biosynthesis and production of bikaverins, fusarubins and fusarins, but not moniliformin as shown by analytical methods. …”
Publicado 2012
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840por Chimalapati, Suneeta, Cohen, Jonathan M., Camberlein, Emilie, MacDonald, Nathanael, Durmort, Claire, Vernet, Thierry, Hermans, Peter W. M., Mitchell, Timothy, Brown, Jeremy S.“…As prolipoproteins are attached to the cell membrane by a single enzyme, prolipoprotein diacylglyceryl transferase (Lgt), deletion of the corresponding gene potentially allows the characterisation of the overall importance of lipoproteins for specific bacterial functions. …”
Publicado 2012
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