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981“…BACKGROUND: Glutathione S-transferase (GST) is a crucial enzyme for metabolism, detoxification, and stress resistance in organisms. …”
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982“…BACKGROUND/AIMS: Our previous work identified the dimethyladenosine transferase 1 homolog as a novel prognostic factor for detecting human gastric carcinoma with high sensitivity and specificity. …”
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983por Ma, Chunhua, Zhang, Zhanhu, Li, Tianqi, Tao, Yumei, Zhu, Guoxiang, Xu, Lili, Ju, Yuanyuan, Huang, Xu, Zhai, Jinyun, Wang, Xingmin“…Chronic inflammation-induced oxidative stress is an important driving force for developing colitis-associated cancer (CAC). 4-hydroxynonenal (4-HNE) is a highly reactive aldehyde derived from lipid peroxidation of ω-6 polyunsaturated fatty acids that contributes to colorectal carcinogenesis. Glutathione S-transferase alpha 4 (Gsta4) specifically conjugates glutathione to 4-HNE and thereby detoxifies 4-HNE. …”
Publicado 2023
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984por Krošel, Monika, Gabathuler, Marcel, Moser, Larissa, Maciukiewicz, Malgorzata, Züllig, Thomas, Seifritz, Tanja, Tomšič, Matija, Distler, Oliver, Ospelt, Caroline, Klein, Kerstin“…CBP and p300 are two highly homologous histone acetyl transferases and writers of activating histone 3 lysine 27 acetylation (H3K27ac) marks. …”
Publicado 2023
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985por Zhang, Lifang, Braynen, Janeen, Fahey, Audrey, Chopra, Kriti, Cifani, Paolo, Tadesse, Dimiru, Regulski, Michael, Hu, Fangle, van Dam, Hubertus J. J., Xie, Meng, Ware, Doreen, Blaby-Haas, Crysten E.“…Analysis of AtZNG1, AtMAP1A, AtMAP2A, and AtMAP2B transgenic mutants are consistent with the role of Arabidopsis ZNG1 as a Zn transferase for AtMAP1A, as previously described in yeast and zebrafish. …”
Publicado 2023
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986por Silva, Caroline Rosa, Flávia da Silva Rovida, Amanda, Gabriele Martins, Juliane, Nathane Nunes de Freitas, Paloma, Ricardo Olchanheski, Luiz, Grange, Luciana, Alvim Veiga Pileggi, Sônia, Pileggi, Marcos“…The stress was controlled by changes in the enzymatic modulation of catalase activity in response to peroxide and glutathione S-transferase activity in response to malondialdehyde, especially at higher herbicide concentrations. …”
Publicado 2023
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987por Ravikumar, Yuvaraj, Koonyosying, Pimpisid, Srichairatanakool, Sirichai, Ponpandian, Lakshmi Naryanan, Kumaravelu, Jayanthi, Srichairatanakool, Somdet“…Recent studies show that EPZ035544 from Epizyme could induce fetal hemoglobin (HbF) levels due to its proven capability to inhibit euchromatin histone lysine methyl transferase (EHMT2). Therefore, the development of EHMT2 inhibitors is considered promising in managing β-thalassemia. …”
Publicado 2023
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988“…Two murine Mabs VA1(IgG1) and VA2(IgG1) were produced against a bacterial fusion protein comprising glutathione S-transferase and five tandem repeats of the MUC1 protein. …”
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989“…The role of glutathione (GSH) and GSH-S-transferase (GST) activity in modulating the cytotoxicity of four platinum drugs and melphalan was evaluated in eight human ovarian carcinoma cell lines. …”
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990“…The isoenzyme Mu of glutathione S-transferase (GSTM1) is dominantly inherited, and the prevalence of this isoenzyme in the population is about 60%. …”
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991por Sarhanis, P., Redman, C., Perrett, C., Brannigan, K., Clayton, R. N., Hand, P., Musgrove, C., Suarez, V., Jones, P., Fryer, A. A., Farrell, W. E., Strange, R. C.“…The importance of polymorphism in the glutathione S-transferase GSTM1, GSTT1 and, cytochrome P450, CYP2D6 loci in the pathogenesis of epithelial ovarian cancer has been assessed in two studies; firstly, a case-control study designed to determine the influence of these genes on susceptibility to this cancer, and secondly, the putative role of these genes in the protection of host cell DNA has been studied by comparing p53 expression in patients with different GSTM1, GSTT1 and CYP2D6 genotypes. …”
Publicado 1996
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992
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993por Welters, M. J., Fichtinger-Schepman, A. M., Baan, R. A., Flens, M. J., Scheper, R. J., Braakhuis, B. J.“…The expression levels of the enzymes glutathione S-transferase (GST) alpha, mu, and pi, the multidrug resistance-related proteins P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and the lung resistance protein (LRP) were determined semiquantitatively by means of immunocytochemistry. …”
Publicado 1998
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994Publicado 1980“…A method is described by which highly enriched populations of viable terminal deoxynucleotidyl transferase-positive (TdT+) cells can be isolated from rat bone marrow by use of the fluorescence-activated cell sorter. …”
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995Publicado 1987“…The cell origin of the rare terminal deoxynucleotidyl transferase (TdT)- positive acute myeloid leukemias (AML) was investigated at the molecular level, by examining the configuration of the Ig H (Igh) and L (Ig kappa, Ig lambda) chain gene regions, and of the T cell receptor (TCR) beta and T cell rearranging (TRG) gamma loci. …”
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996“…The concentrations of glutathione S-transferase (GST) B1 and B2 (Alpha), Pi and Mu have been measured by radioimmunoassay in cytosols from 28 oestrogen receptor (ER) rich an 30 ER-poor breast tumours. …”
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997por Ogiuchi, Yosuke, Maruoka, Yasubumi, Ando, Tomohiro, Kobayashi, Makio, Ogiuchi, Hideki“…We conducted a clinicopathologic study on protein and mRNA levels of thymidylate synthase (TS), thymidine phosphorylase (TP) and orotate phosphoribosyl transferase (OPRT) using biopsy tissue specimens before treatment. …”
Publicado 2008
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998por Sivoňová, Monika, Waczulíková, Iveta, Dobrota, Dušan, Matáková, Tatiana, Hatok, Jozef, Račay, Peter, Kliment, Ján“…BACKGROUND: It has been suggested that polymorphisms in glutathione-S-transferases (GST) could predispose to prostate cancer through a heritable deficiency in detoxification pathways for environmental carcinogens. …”
Publicado 2009
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999por Woodberry, Tonia, Pinzon-Charry, Alberto, Piera, Kim A, Panpisutchai, Yawalak, Engwerda, Christian R, Doolan, Denise L, Salwati, Ervi, Kenangalem, Enny, Tjitra, Emiliana, Price, Ric N, Good, Michael F, Anstey, Nicholas M“…BACKGROUND: The Plasmodium purine salvage enzyme, hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) can protect mice against Plasmodium yoelii pRBC challenge in a T cell-dependent manner and has, therefore, been proposed as a novel vaccine candidate. …”
Publicado 2009
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1000por Mileo, Anna M., Abbruzzese, Claudia, Mattarocci, Stefano, Bellacchio, Emanuele, Pisano, Paola, Federico, Antonio, Maresca, Vittoria, Picardo, Mauro, Giorgi, Alessandra, Maras, Bruno, Schininà, M. Eugenia, Paggi, Marco G.“…METHODOLOGY/PRINCIPAL FINDINGS: By protein-protein interaction analysis, using mass spectrometry, we identified glutathione S-transferase P1-1 (GSTP1) as a novel cellular partner of the HPV-16 E7 oncoprotein. …”
Publicado 2009
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