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10421por Iwao, Yasuhito, Ojima, Hidenori, Kobayashi, Tatsushi, Kishi, Yoji, Nara, Satoshi, Esaki, Minoru, Shimada, Kazuaki, Hiraoka, Nobuyoshi, Tanabe, Minoru, Kanai, Yae“…In specimens from embolized lobes (EMB) and nonembolized lobes (controls), we measured the portal vein to central vein distance (PV-CV), the area and number of hepatocytes per lobule, and apoptotic activity using the terminal deoxynucleotidyl transferase dUTP nick-end labeling assay. Immunohistochemical reactivities were evaluated for light chain 3 (LC3) and lysosomal-associated membrane protein 2 (LAMP2) as autophagy markers and for glutamine synthetase and cytochrome P450 2E1 (CYP2E1) as metabolic zonation markers. …”
Publicado 2017
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10422por Mathew, Lata, Burney, Maryam, Gaikwad, Anjali, Nyshadham, Pranavand, Nugent, Elizabeth K., Gonzalez, Anneliese, Smith, Judith A.“…Four hepatic metabolism phase II pathways—glutathione S transferase (GST), quinone oxidoreductase (QOR), catechol-O-methyltransferases (COMT), and uridine di-phosphate (UDP)-glucuronosyltransferase (UGT)—were evaluated with validated immunoassays. …”
Publicado 2016
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10423por Huang, Li, Li, Zongyi, Tian, Haibin, Wang, Weiguo, Cui, Dawei, Zhou, Zhe, Chen, Xiao, Cheung, Herman S., Xu, Guo-tong, Chen, Yu“…The percentage of terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling-positive apoptotic photoreceptors was significantly lower in the hPDLSC-injected retinas than in those of the control groups. hPDLSCs were also found to express multiple neurotrophic factors, including vascular endothelial growth factor, bioactive basic fibroblast growth factor, brain-derived neurotrophic factor, neurotrophin-3, insulin-like growth factor 1, nerve growth factor, and glial cell line-derived neurotrophic factor. …”
Publicado 2017
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10424por Camara, Soromane, Koffi, Alphonsine A., Ahoua Alou, Ludovic P., Koffi, Kouakou, Kabran, Jean-Paul K., Koné, Aboubacar, Koffi, Mathieu F., N’Guessan, Raphaël, Pennetier, Cédric“…Three resistance mechanisms were identified, involving high allelic frequencies of kdr L1014F mutation (range = 0.46–1), relatively low frequencies of ace-1(R) (below 0.5) and elevated activity of insecticide detoxifying enzymes, mainly mixed function oxidases (MFO), esterase and glutathione S-transferase (GST) in almost all study sites. CONCLUSION: This detailed map of resistance highlights the urgent need to develop new vector control tools to complement current long-lasting insecticidal nets (LLINs) although it is yet unclear whether these resistance mechanisms will impact malaria transmission control. …”
Publicado 2018
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10425por Li, Wenji, Huang, Ying, Sargsyan, Davit, Khor, Tin Oo, Guo, Yue, Shu, Limin, Yang, Anne Yuqing, Zhang, Chengyue, Paredes-Gonzalez, Ximena, Verzi, Michael, Hart, Ronald P., Kong, Ah-Ng“…The top associated disease identified by IPA was adenocarcinoma; however, the cAMP response element-binding protein (CREB)-, histone deacetylase 2 (HDAC2)-, glutathione S-transferase pi (GSTP1)- and polyubiquitin-C (UBC)-related pathways showed significantly altered methylation profiles based on the canonical pathway and network analyses. …”
Publicado 2018
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10426por Yang, Bo, Yan, Shan, Yan, Jianjun, Li, Yafei, Khurwolah, Mohammad Reeaze, Wang, Liansheng, Chen, Zhong“…BACKGROUND: The single nucleotide polymorphism (SNP) rs12040273, a variant of UDP-N–acetylgalactosamine, polypeptide GalNAc-transferase 2, has recently been reported to be significantly associated with development of carotid artery intima-media thickness (IMT) in a Chinese population based on a genome-wide association study. …”
Publicado 2018
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10427por Koronowski, Kevin B., Khoury, Nathalie, Morris-Blanco, Kahlilia C., Stradecki-Cohan, Holly M., Garrett, Timothy J., Perez-Pinzon, Miguel A.“…Additionally, perturbations in β-oxidation and carnitine transferase (pentadecanoic acid, heptadecanoic acid) and glutamate transport and glutamine synthetase (urea, xylitol, adenine, adenosine, glycine, glutamic acid) were predicted. …”
Publicado 2018
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10428“…AIM: To investigate the interactions of the DNA repair gene excision repair cross complementing group 5 (ERCC5) and the metabolic gene glutathione S-transferase pi 1 (GSTP1) and their effects on atrophic gastritis (AG) and gastric cancer (GC) risk. …”
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10429por Sriwattanapong, Kanokwan, Slocum, Stephen L., Chawanthayatham, Supawadee, Fedeles, Bogdan I., Egner, Patricia A., Groopman, John D., Satayavivad, Jutamaad, Croy, Robert G., Essigmann, John M.“…The main detoxification pathway of the AFB(1)-epoxide involves phase II metabolic enzymes including the glutathione-S-transferase (GST) family. Pregnancy can modulate both phase I and II metabolism and alter the biological potency of AFB(1). …”
Publicado 2017
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10430por Genoula, Melanie, Marín Franco, José Luis, Dupont, Maeva, Kviatcovsky, Denise, Milillo, Ayelén, Schierloh, Pablo, Moraña, Eduardo Jose, Poggi, Susana, Palmero, Domingo, Mata-Espinosa, Dulce, González-Domínguez, Erika, León Contreras, Juan Carlos, Barrionuevo, Paula, Rearte, Bárbara, Córdoba Moreno, Marlina Olyissa, Fontanals, Adriana, Crotta Asis, Agostina, Gago, Gabriela, Cougoule, Céline, Neyrolles, Olivier, Maridonneau-Parini, Isabelle, Sánchez-Torres, Carmen, Hernández-Pando, Rogelio, Vérollet, Christel, Lugo-Villarino, Geanncarlo, Sasiain, María del Carmen, Balboa, Luciana“…We found that TB-PE induced FM differentiation as observed by the increase in lipid bodies, intracellular cholesterol, and expression of the scavenger receptor CD36, as well as the enzyme acyl CoA:cholesterol acyl transferase (ACAT). Importantly, interleukin-10 (IL-10) depletion from TB-PE prevented the augmentation of all these parameters. …”
Publicado 2018
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10431por He, Hefan, Liu, Weifeng, Zhou, Yingying, Liu, Yibin, Weng, Peiqing, Li, Yasong, Fu, Huangde“…Evaluation of the modified neurological severity scores, measurement of brain water content, Nissl staining, and terminal deoxynucleotidyl transferase dUTP nick end labeling assay were used to determine the neuroprotective effects of the sevoflurane post-conditioning. …”
Publicado 2018
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10432“…At the time of their visit, they were suspected as having hepatitis due to elevated aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and total bilirubin levels and were hospitalized. …”
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10433por Mor‐Vaknin, Nirit, Rivas, Miguel, Legendre, Maureen, Mohan, Smriti, Yuanfan, Ye, Mau, Theresa, Johnson, Anne, Huang, Bin, Zhao, Lili, Kimura, Yukiko, Spalding, Steven J., Morris, Paula W., Gottlieb, Beth S., Onel, Karen, Olson, Judyann C., Edelheit, Barbara S., Shishov, Michael, Jung, Lawrence K., Cassidy, Elaine A., Prahalad, Sampath, Passo, Murray H., Beukelman, Timothy, Mehta, Jay, Giannini, Edward H., Adams, Barbara S., Lovell, Daniel J., Markovitz, David M.“…The C‐terminal 25‐aa fragment of DEK was expressed in a glutathione S‐transferase–tagged vector. ELISA results were calculated as area under the curve by the trapezoidal rule. …”
Publicado 2018
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10434por Parthasarathy, Anutthaman, Cross, Penelope J., Dobson, Renwick C. J., Adams, Lily E., Savka, Michael A., Hudson, André O.“…Emphasis will be placed on structural and functional aspects of several key AAA-related enzymes, such as shikimate synthase, chorismate mutase, anthranilate synthase, tryptophan synthase, tyrosine aminotransferase, dopachrome tautomerase, radical dehydratase, and type III CoA-transferase. The past development and current potential for interventions including the development of herbicides and antibiotics that target key enzymes in AAA-related pathways, as well as AAA-linked secondary metabolism leading to antimicrobials are also discussed.…”
Publicado 2018
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10435por Hägele, Franziska A, Büsing, Franziska, Nas, Alessa, Aschoff, Julian, Gnädinger, Lena, Schweiggert, Ralf, Carle, Reinhold, Bosy-Westphal, Anja“…By contrast, after WM-intervention fat mass and gamma-glutamyl transferase (GGT) decreased (−0.30 ± 0.65 kg; −2.50 ± 3.94; both p < 0.05), whereas glucose variability was higher (ΔMAGE: +0.45 ± 0.59, p < 0.05). …”
Publicado 2018
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10436“…In a second step, we observed that M. ulcerans genome uniquely encoded chitinase, fucosidase and A-D-GlcNAc-diphosphoryl polyprenol A-3-L-rhamnosyl transferase giving M. ulcerans the potential to metabolize chitine, fucose and N-acetyl galactosamine (NAG), respectively. …”
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10437“…Neuronal apoptosis and the expressions of NR1 mRNA and protein in the frontal cortex were also examined by transferase dUTP nick end labeling (TUNEL) assays, qPCR and Western blot, respectively. …”
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10438por Hui, Tianqian, Zhou, Yachuan, Wang, Tingyu, Li, Jun, Zhang, Shanxing, Liao, Lifan, Gu, Jianhong, Ye, Ling, Zhao, Lan, Chen, Di“…Results of proliferating cell nuclear antigen (PCNA), Ki67, and terminal deoxinucleotidyl transferase-mediated dUTP-fluorescein nick end labeling (TUNEL) staining further demonstrated that cell proliferation was decreased and cell apoptosis was increased in condylar cartilage of β-cat(ex3)(Agc1CreER) mice. …”
Publicado 2018
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10439por Liu, Xianghe, Zhao, Yahui, Zhang, Weina, Gao, Yang, Huo, Miaomiao, Liu, Mei, Xiao, Zefen, Liang, Shufang, Xu, Ningzhi, Zhu, Hongxia“…Terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay, fluorescein isothiocyanate-labeled Annexin V/propidium iodide assay, and poly ADP-ribose polymerase cleavage were used to detect apoptosis. …”
Publicado 2018
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10440por Zhou, Wei, Quan, Juan-Hua, Gao, Fei-Fei, Ismail, Hassan Ahmed Hassan Ahmed, Lee, Young-Ha, Cha, Guang-Ho“…The selected genes include PH domain and leucine- rich-repeat protein phosphatases (PHLPP), casein kinase2 (CK2), vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), glutamate-cysteine ligase (GCL), glutathione S-transferase (GST), and NAD(P)H: quinone oxidoreductase (NQO1). …”
Publicado 2018
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