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1101“…The proliferation of vascular smooth muscle cells (VSMCs) induced by oxidative injury is one of the main features in diabetes-accelerated atherosclerosis. Geranylgeranyl transferase-I (GGTase-I) is an essential enzyme mediating posttranslational modification, especially the geranylgeranylation of small GTPase, Rac1. …”
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1102por Goulooze, Sebastiaan C., Kruithof, Annelieke C., Alikunju, Shanavas, Gautam, Anirudh, Burggraaf, Jacobus, Kamerling, Ingrid M.C., Stevens, Jasper“…We aimed to characterise the population pharmacokinetics of cholesteryl ester transferase protein inhibitor DRL‐17822 in healthy males and explore the effect of food and formulation on the oral absorption of DRL‐17822 in 4 phase I studies. …”
Publicado 2020
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1103por Lee, Da Young, Han, Kyungdo, Yu, Ji Hee, Park, Sanghyun, Seo, Ji A, Kim, Nam Hoon, Yoo, Hye Jin, Kim, Sin Gon, Kim, Seon Mee, Choi, Kyung Mook, Baik, Sei Hyun, Park, Yong Gyu, Kim, Nan Hee“…We examined whether long-term gamma-glutamyl transferase (GGT) variability can predict cardiovascular disease (CVD) and mortality in individuals with diabetes. …”
Publicado 2020
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1104por Barkovskaya, Anna, Seip, Kotryna, Prasmickaite, Lina, Mills, Ian G., Moestue, Siver A., Itkonen, Harri M.“…In this study, we probed the importance of O-GlcNAc transferase (OGT) activity for the survival of tamoxifen-sensitive (TamS) and tamoxifen-resistant (TamR) breast cancer cells. …”
Publicado 2020
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1105por Pagnotta, Priscila Ayelén, Melito, Viviana Alicia, Lavandera, Jimena Verónica, Parera, Victoria Estela, Rossetti, María Victoria, Zuccoli, Johanna Romina, Buzaleh, Ana Maria“…The GSTT1 null, GSTM1 null and GSTP1 (c.313A>G) gene variants alter Glutathione S-transferase (GST) activity, modifying the levels of xenobiotics. …”
Publicado 2021
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1106por Zhou, Jun, Wang, Suying, Zhu, Lun, Zhou, Luting, Zeng, Hong, Gan, Yongli, Wang, Chaofu“…AIM: The concrete features of expression of terminal deoxynucleotidyl transferase (TdT) are needed to be revealed in male and female germ cell tumors (GCTs). …”
Publicado 2021
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1107“…Despite evident differences in composition, structure and underlaying biosynthesis pathways, the final ligation step of CWGPs to the PGN backbone involves a conserved class of enzymes—the LytR-CpsA-Psr (LCP) transferases. Typically, the enzymes are present in multiple copies displaying partly functional redundancy and/or preference for a distinct CWGP type. …”
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1108por Sugiura, Minoru, Nakamura, Mieko, Ikoma, Yoshinori, Yano, Masamichi, Ogawa, Kazunori, Matsumoto, Hikaru, Kato, Masaya, Ohshima, Makoto, Nagao, AkihikoEnlace del recurso
Publicado 2005
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1109por Zhao, Xinxin, Shen, Hui, Liang, Sheng, Zhu, Dekang, Wang, Mingshu, Jia, Renyong, Chen, Shun, Liu, Mafeng, Yang, Qiao, Wu, Ying, Zhang, Shaqiu, Huang, Juan, Ou, Xumin, Mao, Sai, Gao, Qun, Zhang, Ling, Liu, Yunya, Yu, Yanling, Pan, Leichang, Cheng, Anchun“…Here we further dissected the roles of the outer core transferase genes pcgD and hptE in bacterial resistance to duck serum, outer membrane permeability and virulence in ducks. …”
Publicado 2021
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1110por Seo, Hyung-Ju, Ji, Seung-Bae, Kim, Sin-Eun, Lee, Gyung-Min, Park, So-Young, Wu, Zhexue, Jang, Dae Sik, Liu, Kwang-Hyeon“…Herein, we investigated the drug interaction potential of six dibenzocyclooctadiene lignans (schisandrin, gomisin A, B, C, and N, and wuweizisu C) on nine P450 enzymes (CYP1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A) and six uridine 5′-diphosphoglucuronosyl transferase (UGT) enzymes (UGT1A1, 1A3, 1A4, 1A6, 1A9, and 2B7) using human liver microsomes. …”
Publicado 2021
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1111“…Two enzymes are responsible for O-GlcNAc cycling on substrate proteins: O-GlcNAc transferase (OGT) catalyzes the addition while O-GlcNAcase (OGA) helps the removal of GlcNAc. …”
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1112por Fathima, Tahreem, Arumugam, Paramasivam, AS, Smiline Girija, Priyadharsini, J Vijayashree“…In line with the above fact, the present study has been designed to identify genetic alterations in the genes of the DNMT (DNA methyl-transferase) family among head and neck squamous cell carcinoma patients (HNSCC). …”
Publicado 2020
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1113por Bijnens, Esmée M., Derom, Catherine, Thiery, Evert, Martens, Dries S., Loos, Ruth J. F., Weyers, Steven, Nawrot, Tim S.“…Therefore, we studied the association between gamma-glutamyl transferase (GGT), a widely used biomarker of alcohol intake, and telomere length. …”
Publicado 2021
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1114por Song, Wen, Zhou, Fake, Shan, Chunhui, Zhang, Qin, Ning, Ming, Liu, Xiumin, Zhao, Xinxin, Cai, Wenchao, Yang, Xinquan, Hao, Guangfei, Tang, Fengxian“…As a group of multifunctional enzymes, glutathione S-transferases (GSTs) participate in oxidative stress resistance and cellular detoxification. …”
Publicado 2021
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1116por Jenni, Aurelio, Knüsel, Sebastian, Nagar, Rupa, Benninger, Mattias, Häner, Robert, Ferguson, Michael A.J., Roditi, Isabel, Menon, Anant K., Bütikofer, Peter“…We generated insect-stage (procyclic) trypanosomes that lack TbGPI2 and found that in TbGPI2-null parasites, (i) GPI GlcNAc transferase activity is reduced, but not lost, in contrast with yeast and human cells, (ii) the GPI GlcNAc transferase complex persists, but its architecture is affected, with loss of at least the TbGPI1 subunit, and (iii) the GPI anchors of procyclins, the major surface proteins, are underglycosylated when compared with their WT counterparts, indicating the importance of TbGPI2 for reactions that occur in the Golgi apparatus. …”
Publicado 2021
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1117por Araujo, Oscar C., de Paula, Vanessa S., do Ó, Kycia M., Villela-Nogueira, Cristiane A., Araujo, Natalia M.“…The present study was conducted to determine the influence of glutathione S-transferase (GST)-M1 and T1 gene polymorphisms during different stages of HCV infection, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). …”
Publicado 2021
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1118por Suthakaran, Nirthieca, Wiggins, Jonathan, Giles, Andrew, Opperman, Karla J., Grill, Brock, Dawson-Scully, KenEnlace del recurso
Publicado 2021
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1119por Sobhani, Sahar, Aryan, Reihaneh, AkbariRad, Mina, Ebrahimi Miandehi, Elahe, Alinezhad-Namaghi, Maryam, Sobhani, Seyyed Reza, Raji, Sara“…This study is aimed at investigating the association between anthropometric indices with gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). …”
Publicado 2021
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1120“…The structural findings were confirmed by functional activity assays and suggest a model for the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases, which synthetize the phospholipids essential for the cells.…”
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