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12281por Caza, Tiffany N, Fernandez, David R, Talaber, Gergely, Oaks, Zachary, Haas, Mark, Madaio, Michael P, Lai, Zhi-wei, Miklossy, Gabriella, Singh, Ram R, Chudakov, Dmitriy M, Malorni, Walter, Middleton, Frank, Banki, Katalin, Perl, Andras“…Therefore, we investigated whether (1) HRES-1/Rab4 impacts mitochondrial homeostasis and (2) Rab geranylgeranyl transferase inhibitor 3-PEHPC blocks mitochondrial accumulation in T cells, autoimmunity and disease development in lupus-prone mice. …”
Publicado 2014
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12282por Beecham, Gary W., Hamilton, Kara, Naj, Adam C., Martin, Eden R., Huentelman, Matt, Myers, Amanda J., Corneveaux, Jason J., Hardy, John, Vonsattel, Jean-Paul, Younkin, Steven G., Bennett, David A., De Jager, Philip L., Larson, Eric B., Crane, Paul K., Kamboh, M. Ilyas, Kofler, Julia K., Mash, Deborah C., Duque, Linda, Gilbert, John R., Gwirtsman, Harry, Buxbaum, Joseph D., Kramer, Patricia, Dickson, Dennis W., Farrer, Lindsay A., Frosch, Matthew P., Ghetti, Bernardino, Haines, Jonathan L., Hyman, Bradley T., Kukull, Walter A., Mayeux, Richard P., Pericak-Vance, Margaret A., Schneider, Julie A., Trojanowski, John Q., Reiman, Eric M., Schellenberg, Gerard D., Montine, Thomas J.“…Genome-wide significance was observed for clinico-pathologic AD dementia, NPs, NFTs, CAA, and LBD with a number of variants in and around the apolipoprotein E gene (APOE). GalNAc transferase 7 (GALNT7), ATP-Binding Cassette, Sub-Family G (WHITE), Member 1 (ABCG1), and an intergenic region on chromosome 9 were associated with NP score; and Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta Member 2 (KCNMB2) was strongly associated with HS. …”
Publicado 2014
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12283por Ferreiro-Iglesias, Aida, Calaza, Manuel, Perez-Pampin, Eva, Lopez Longo, Francisco J, Marenco, Jose L, Blanco, Francisco J, Narvaez, Javier, Navarro, Federico, Cañete, Juan D, de la Serna, Arturo R, Gonzalez-Alvaro, Isidoro, Herrero-Beaumont, Gabriel, Pablos, Jose L, Balsa, Alejandro, Fernandez-Gutierrez, Benjamin, Caliz, Rafael, Gomez-Reino, Juan J, Gonzalez, Antonio“…The other showed interactions between the SE and the null genotype of glutathione S-transferase Mu 1 (GSTM1) in the anti–cyclic citrullinated peptide–positive (anti-CCP(+)) patients. …”
Publicado 2014
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12284por Flanagan, L, Meyer, M, Fay, J, Curry, S, Bacon, O, Duessmann, H, John, K, Boland, K C, McNamara, D A, Kay, E W, Bantel, H, Schulze-Bergkamen, H, Prehn, J H M“…Exposure of explant cultures to 5FU-based CT increased the percentage of cells positive for active Caspase-3 and Terminal Deoxynucleotidyl Transferase dUTP Nick end Labelling (TUNEL), but also the expression of regeneration and proliferation markers β-Catenin and Ki-67, as well as cyclooxygenase-2 (COX-2). …”
Publicado 2016
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12285por Phoomak, Chatchai, Silsirivanit, Atit, Park, Dayoung, Sawanyawisuth, Kanlayanee, Vaeteewoottacharn, Kulthida, Wongkham, Chaisiri, Lam, Eric W.-F., Pairojkul, Chawalit, Lebrilla, Carlito B., Wongkham, Sopit“…Global O-GlcNAcylation in CCA cells was depleted using specific siRNA against O-GlcNAc transferase (OGT), which transfers GlcNAc to the acceptor proteins. …”
Publicado 2018
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12286por Ledesma-Ramírez, Lourdes, Solís-Moya, Ernesto, Iturriaga, Gabriel, Sehgal, Deepmala, Reyes-Valdes, M. Humberto, Montero-Tavera, Víctor, Sansaloni, Carolina P., Burgueño, Juan, Ortiz, Cynthia, Aguirre-Mancilla, César L., Ramírez-Pimentel, Juan G., Vikram, Prashant, Singh, Sukhwinder“…In silico analysis of the identified SNPs showed hits with interesting candidate genes, which are related to pathogenic process or known to regulate induction of genes related to pathogenesis such as those coding for glunolactone oxidase, quinate O-hydroxycinnamoyl transferase, or two-component histidine kinase. The two-component histidine kinase, for example, acts as a sensor in the perception of phytohormones ethylene and cytokinin. …”
Publicado 2019
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12287por Yu, Linyuan, Gong, Lihong, Wang, Cheng, Hu, Naihua, Tang, Yunqiu, Zheng, Li, Dai, Xuyang, Li, Yunxia“…Further investigation indicated that RPMP and emodin reduced hepatic lipogenesis via up-regulating the expressions of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT2), amp-activated protein kinase alpha (AMPKα), proliferator-activated receptor alpha (PPARα), carnitine palmitoyl transferase 1a (CPT-1a) and acyl-coenzyme A oxidase 1 (ACOX1). …”
Publicado 2020
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12288por Maev, Igor V, Samsonov, Aleksey A, Palgova, Liudmila K, Pavlov, Chavdar S, Shirokova, Elena N, Vovk, Elena I, Starostin, Kirill M“…Laboratory data were collected at baseline and 12 and 24 weeks of the study, and included liver function tests (aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT)), fasting plasma glucose, and lipid profile. …”
Publicado 2020
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12289por Yang, Chih-Jen, Huang, Yu-Jung, Wang, Cheng-Yuan, Wang, Pei-Hui, Hsu, Hseng-Kuang, Tsai, May-Jywan, Chen, Yu-Chu, Bharath Kumar, V., Huang, Ming-Shyan, Weng, Ching-Feng“…Thus, the TSL-1–induced apoptosis was further confirmed by cell morphology, subG1 peak accumulation, poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) cleavage, propidium iodide (PI)-Annexin-V double staining, and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay. …”
Publicado 2010
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12290por Darko, Samuel Nkansah, Hanson, Henry, Twumasi-Ankrah, Sampson, Baffour-Awuah, Sandra, Adjei-Kusi, Priscilla, Yar, Denis, Owusu-Dabo, Ellis“…Similarly, levels of alanine aminotransferase (p = 0.001), aspartate aminotransferase (p = 0.028) and gamma glutamyl transferase (p = 0.001) significantly declined towards post-treatment. …”
Publicado 2020
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12291“…Biochemical assessments including fasting blood sugar (FBS), aspartate aminotransferase (AST), alanine amino transferase (ALT) and serum lipids were performed by enzymatic methods. …”
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12292por Ma, Qingqing, Dong, Xiaoyu, Liu, Siyu, Zhong, Tao, Sun, Dandan, Zong, Lu, Zhao, Changcheng, Lu, Qiong, Zhang, Min, Gao, Yufeng, Ye, Ying, Cheng, Jun, Xu, Yuanhong, Zheng, Meijuan“…The frequencies of NKG2A(+) NK cells and IL-10(+) Tregs, along with serum levels of alanine transferase and HBV DNA, were significantly increased in CHB patients positive for the Hepatitis B e antigen (HBeAg, a marker of viral replication) when compared to HBeAg-negative CHB patients. …”
Publicado 2020
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12293por Pertiwi, Kamalita, Küpers, Leanne K., Geleijnse, Johanna M., Zock, Peter L., Wanders, Anne J., Kruger, Herculina S., van Zyl, Tertia, Kruger, Iolanthé M., Smuts, Cornelius M.“…Blood samples were collected to measure circulating LA (% total fatty acids (FA); plasma phospholipids), plasma glucose, glycosylated hemoglobin (HbA1c), serum gamma-glutamyl transferase (GGT), alanine (ALT) and aspartate aminotransferase (AST). …”
Publicado 2020
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12294por Shi, Chengyu, Wang, Qi, Rao, Zhuqing, Shi, Yong, Wei, Song, Wang, Hao, Lu, Xu, Wang, Ping, Lu, Ling, Zhou, Haoming, Cheng, Feng“…Interestingly, IR induces the pyroptosis of hepatocytes in db/db mice, as evidenced by enhanced NLRP3 inflammasome activation, increased numbers of terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL)-positive hepatocytes and increased gene expression of interleukin-1β (IL-1β) and IL-18 in livers post-IR. …”
Publicado 2020
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12295por Amera, Gizachew Muluneh, Khan, Rameez Jabeer, Jha, Rajat Kumar, Pathak, Amita, Muthukumaran, Jayaraman, Singh, Amit Kumar“…RESULTS: From the results of protein sequence analysis of eight Mur family proteins, they divided into three main enzymatic classes namely transferases (MurG, MurA and MraY), ligases (MurC, MurD, MurE, and MurF), and oxidoreductase (MurB). …”
Publicado 2020
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12296“…Venn and bioinformatics analyses of DEGs showed that short-term HS strongly activated heat shock proteins (Hsps) and heat shock factors (Hsfs), as well as specifically activated FK506-binding proteins (FKBPs), calcium signaling genes, glutathione S-transferase genes, photosynthesis-related genes, and phytohormone signaling genes. …”
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12297por Varghese, Anu Mary, Ghosh, Mausam, Bhagat, Savita Kumari, Vijayalakshmi, K., Preethish-Kumar, Veeramani, Vengalil, Seena, Chevula, Pradeep-Chandra-Reddy, Nashi, Saraswati, Polavarapu, Kiran, Sharma, Meenakshi, Dhaliwal, Rupinder Singh, Philip, Mariamma, Nalini, Atchayaram, Alladi, Phalguni Anand, Sathyaprabha, Talakad N., Raju, Trichur R.“…Lumbar spinal cord sections were stained for Iba1, glial fibrillary acidic protein and choline acetyl transferase to identify microglia, astrocytes and motor neurons respectively after 48 h of injection. …”
Publicado 2020
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12298por Fernando, H. Sachini D., Saavedra-Rodriguez, Karla, Perera, Rushika, Black, William C., De Silva, B. G. D. Nissanka Kolitha“…An assessment of the activity of metabolic detoxifying enzymes (multifunction oxidases (MFOs), glutathione S-transferases (GSTs) and esterases) and determination of frequency of the kdr mutations (F1534C, V1016G and S989P) were also carried out to ascertain the associated resistance mechanisms. …”
Publicado 2020
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12299por Atoyebi, Seun M., Tchigossou, Genevieve M., Akoton, Romaric, Riveron, Jacob M., Irving, Helen, Weedall, Gareth, Tossou, Eric, Djegbe, Innocent, Oyewole, Isaac O., Bakare, Adekunle A., Wondji, Charles S., Djouaka, Rousseau“…Microarray and RT-PCR analyses revealed the overexpression of glutathione S-transferase genes, cytochrome P450s, esterase, trypsin and cuticle proteins in resistant mosquitoes compared to control. …”
Publicado 2020
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12300“…L-ascorbate peroxidase 3 and catalase were down-regulated during low temperature storage. α-amylase, sucrose synthase and fructokinase were significantly up-regulated in starch and sucrose metabolism, while β-glucosidase, glucose-1-phosphate adenylyl-transferase and starch synthase were opposite. Furthermore, metabolome profiling revealed that glucosinolate biosynthesis, tropane, piperidine and pyridine alkaloid biosynthesis as well as protein digestion and absorption played a leading role in metabolic pathways of roots. …”
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