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1281“…Although the half-life is short, AFB1-8,9-exo-epoxide does react with DNA and glutathione S-transferase. Levels of these conjugates have been measured and combined with the rate of hydrolysis in a kinetic model to predict constants for binding of the epoxide with DNA and glutathione S-transferase. …”
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1282“…Provisional mutational spectra at the hypoxanthine phosphoribosyl transferase (HPRT) locus in vitro have been worked out for acetaldehyde (AA) and benzo[a]pyrene diolepoxide (BPDE) in human (T)-lymphocytes and for ethylene oxide (EtO) in human diploid fibroblasts using Southern blotting and polymerase chain reaction (PCR)-based DNA sequencing techniques. …”
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1283por Asojo, Oluwatoyin A, Homma, Kohei, Sedlacek, Meghan, Ngamelue, Michelle, Goud, Gaddam N, Zhan, Bin, Deumic, Vehid, Asojo, Oluyomi, Hotez, Peter J“…Adult stage antigens include the cytosolic glutathione-S-transferases (GSTs). Nematode GSTs facilitate the inactivation and degradation of a variety of electrophilic substrates (drugs) via the nucleophilic addition of reduced glutathione. …”
Publicado 2007
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1284por Ghazal-Aswad, S., Hogarth, L., Hall, A. G., George, M., Sinha, D. P., Lind, M., Calvert, A. H., Sunter, J. P., Newell, D. R.“…There is evidence to suggest that glutathione (GSH) and glutathione-S-transferases (GST) are important factors in determining sensitivity to cytotoxic drugs in vitro and in preclinical in vivo model systems. …”
Publicado 1996
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1285por Robinson, Arthur“…A simple, rapid, and direct method for measuring the activities of the galactokinase and Gal-1-P uridyl transferase enzymes in human erythrocytes is presented. …”
Publicado 1963
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1286
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1287por Melén, Erik, Nyberg, Fredrik, Lindgren, Cecilia M., Berglind, Niklas, Zucchelli, Marco, Nordling, Emma, Hallberg, Jenny, Svartengren, Magnus, Morgenstern, Ralf, Kere, Juha, Bellander, Tom, Wickman, Magnus, Pershagen, Göran“…OBJECTIVE: Our goal was to assess interactions between exposure to air pollution and single nucleotide polymorphisms (SNPs) in the β2-adrenergic receptor (ADRB2), glutathione S-transferase P1 (GSTP1), and tumor necrosis factor (TNF) genes for development of childhood allergic disease. …”
Publicado 2008
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1288
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1289“…Whilst the DHHC domain dependant S-acyl transferase (palmitoyl transferase) function of AKR1 is well documented it is not known whether the ankyrin repeats are also required for this activity. …”
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1290por Ussher, John R., Folmes, Clifford D. L., Keung, Wendy, Fillmore, Natasha, Jaswal, Jagdip S., Cadete, Virgilio J., Beker, Donna L., Lam, Victoria H., Zhang, Liyan, Lopaschuk, Gary D.“…MATERIALS AND METHODS: C57BL/6 mice were fed a low fat diet or subjected to DIO for 12 weeks, and then treated for 4 weeks with either vehicle control or the serine palmitoyl transferase I (SPT I) inhibitor, myriocin. In vivo cardiac function was assessed via ultrasound echocardiography, while glucose metabolism was assessed in isolated working hearts. …”
Publicado 2012
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1291por Allen, Mariet, Zou, Fanggeng, Chai, High Seng, Younkin, Curtis S, Miles, Richard, Nair, Asha A, Crook, Julia E, Pankratz, V Shane, Carrasquillo, Minerva M, Rowley, Christopher N, Nguyen, Thuy, Ma, Li, Malphrus, Kimberly G, Bisceglio, Gina, Ortolaza, Alexandra I, Palusak, Ryan, Middha, Sumit, Maharjan, Sooraj, Georgescu, Constantin, Schultz, Debra, Rakhshan, Fariborz, Kolbert, Christopher P, Jen, Jin, Sando, Sigrid B, Aasly, Jan O, Barcikowska, Maria, Uitti, Ryan J, Wszolek, Zbigniew K, Ross, Owen A, Petersen, Ronald C, Graff-Radford, Neill R, Dickson, Dennis W, Younkin, Steven G, Ertekin-Taner, Nilüfer“…BACKGROUND: Glutathione S-transferase omega-1 and 2 genes (GSTO1, GSTO2), residing within an Alzheimer and Parkinson disease (AD and PD) linkage region, have diverse functions including mitigation of oxidative stress and may underlie the pathophysiology of both diseases. …”
Publicado 2012
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1292por Jankova, Lucy, Robertson, Graham, Chan, Charles, Tan, King L, Kohonen-Corish, Maija, Fung, Caroline L-S, Clarke, Candice, Lin, Betty P C, Molloy, Mark, Chapuis, Pierre H, Bokey, Les, Dent, Owen F, Clarke, Stephen J“…BACKGROUND: This study examined the association between overall survival and Glutathione S-transferase Pi (GST Pi) expression and genetic polymorphism in stage C colon cancer patients after resection alone versus resection plus 5-fluourouracil-based adjuvant chemotherapy. …”
Publicado 2012
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1293“…The changes in glutathione-S-transferase (GST) activity and expression were determined by enzyme activity assay and Western blot analysis, respectively. …”
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1294por Zhou, Wen-Wu, Liang, Qing-Mei, Xu, Yi, Gurr, Geoff M., Bao, Yan-Yuan, Zhou, Xue-Ping, Zhang, Chuan-Xi, Cheng, Jiaan, Zhu, Zeng-Rong“…BACKGROUND: Glutathione S-transferase (GST) genes control crucial traits for the metabolism of various toxins encountered by insects in host plants and the wider environment, including insecticides. …”
Publicado 2013
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1295por Wongtrakul, Jeerang, Sukittikul, Suchada, Saisawang, Chonticha, Ketterman, Albert J.“…Glutathione transferases (GSTs) are a family of multifunctional enzymes involved in xenobiotic biotransformation, drug metabolism, and protection against oxidative damage. …”
Publicado 2012
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1296por Kolesnikov, Yuri, Gabovits, Boris, Levin, Ariel, Veske, Andres, Qin, Li, Dai, Feng, Belfer, Inna“…In this study, we aimed to determine whether the catechol-O-methyl transferase (COMT) and opioid receptor μ-1 (OPRM1) common functional polymorphisms rs4680 and rs1799971 were associated with the incidence, intensity, or duration of CPP in patients after lower abdominal surgery. …”
Publicado 2013
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1297por Yang, Xingliang, Long, Shuyu, Deng, Jianping, Deng, Tianxing, Gong, Zhihua, Hao, Ping“…BACKGROUND: The association of the three Glutathione S-transferases (GSTs) polymorphisms (GSTM1, GSTT1 and GSTP1) genotypes with their individual susceptibilities to renal cell carcinoma (RCC) has not been well established. …”
Publicado 2013
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1298por Nagarajan, Prabakaran, Ge, Zhongqi, Sirbu, Bianca, Doughty, Cheryl, Agudelo Garcia, Paula A., Schlederer, Michaela, Annunziato, Anthony T., Cortez, David, Kenner, Lukas, Parthun, Mark R.Enlace del recurso
Publicado 2013
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1299por Tu, Yaqin, Hu, Yang, Fan, Guorun, Chen, Zhihao, Liu, Lin, Man, Dandan, Liu, Shuojie, Tang, Chengwu, Zhang, Yin, Dai, WuxingEnlace del recurso
Publicado 2014
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1300por Licciardello, Concetta, D’Agostino, Nunzio, Traini, Alessandra, Recupero, Giuseppe Reforgiato, Frusciante, Luigi, Chiusano, Maria Luisa“…BACKGROUND: Glutathione S-transferases (GSTs) represent a ubiquitous gene family encoding detoxification enzymes able to recognize reactive electrophilic xenobiotic molecules as well as compounds of endogenous origin. …”
Publicado 2014
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