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1841por Rodriguez-Navarro, Jose Antonio, Pascual-Guerra, Jorge, Sacristan, Silvia, Nogales, Maria del Carmen, Fafián-Labora, Juan Antonio, O’Loghlen, Ana“…Small extracellular vesicles released by fibroblasts from young human donors diminish lipid peroxidation in senescent cells and in different old mice organs due to their enrichment in Glutathione-S-transferase Mu lipid antioxidant activity.…”
Publicado 2020
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1842por AL Abdan, M.“…As a consequence, LA regulated liver enzymes, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transferase. The data also indicated the efficiency of LA as cancer inhibitor and therapeutic influence. …”
Publicado 2012
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1843por Genz, Maika, Vickers, Clare, van den Bergh, Tom, Joosten, Henk-Jan, Dörr, Mark, Höhne, Matthias, Bornscheuer, Uwe T.“…These positions were targeted for mutagenesis with a focused alphabet of hydrophobic amino acids to convert an amine:α-keto acid transferase into an amine:aldehyde transferase. Screening of 1200 variants revealed three hits, which showed a shifted amine donor/acceptor spectrum towards aliphatic aldehydes (mainly pentanal), as well as an altered pH profile. …”
Publicado 2015
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1844por Calmels, Christina, Ventura, Michel, Aknin, Cindy, Métifiot, Mathieu, Andreola, Marie-Line“…For this, it is essential to develop biochemical tools to help study and target key viral enzymes involved in replication such as helicase complexes, methyl-transferases and RNA-dependent RNA polymerases. Here, we show that a highly purified ZIKV polymerase domain is active in vitro. …”
Publicado 2017
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1845“…The present study was designed to investigate the use of specific biomarkers, such as albumin, serum total protein, aspartate amino transferase (AST), globulin, alanine amino transferase (ALT), serum cortisol and alkaline phosphatase (ALP), as predictive tools for sarcoptic mange in rabbits. …”
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1846por Booty, Lee M., Gawel, Justyna M., Cvetko, Filip, Caldwell, Stuart T., Hall, Andrew R., Mulvey, John F., James, Andrew M., Hinchy, Elizabeth C., Prime, Tracy A., Arndt, Sabine, Beninca, Cristiane, Bright, Thomas P., Clatworthy, Menna R., Ferdinand, John R., Prag, Hiran A., Logan, Angela, Prudent, Julien, Krieg, Thomas, Hartley, Richard C., Murphy, Michael P.“…To overcome this constraint we modified the glutathione S-transferase substrate and Trx reductase (TrxR) inhibitor, 1-chloro-2,4-dinitrobenzene (CDNB) by conjugation to the mitochondria-targeting triphenylphosphonium cation. …”
Publicado 2019
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1847por Powers, Kyle T, Stevenson-Jones, Flint, Yadav, Sathish K N, Amthor, Beate, Bufton, Joshua C, Borucu, Ufuk, Shen, Dakang, Becker, Jonas P, Lavysh, Daria, Hentze, Matthias W, Kulozik, Andreas E, Neu-Yilik, Gabriele, Schaffitzel, Christiane“…Blasticidin S (BlaS) targets translation by binding to the peptidyl transferase center of the large ribosomal subunit. Using biochemical, structural and cellular approaches, we show here that BlaS inhibits both translation elongation and termination in Mammalia. …”
Publicado 2021
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1848por Becker, Tobias, Cappel, Cedric, Di Matteo, Francesco, Sonsalla, Giovanna, Kaminska, Ewelina, Spada, Fabio, Cappello, Silvia, Damme, Markus, Kielkowski, Pavel“…In metazoans two highly conserved protein AMP-transferases together with a diverse group of AMPylated proteins have been identified using chemical proteomics and biochemical techniques. …”
Publicado 2021
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1849por Robarts, Dakota R., Kotulkar, Manasi, Paine-Cabrera, Diego, Venneman, Kaitlyn K., Hanover, John A., Zachara, Natasha E., Slawson, Chad, Apte, Udayan“…BACKGROUND: O-GlcNAcylation is a post-translational modification catalyzed by the enzyme O-GlcNAc transferase, which transfers a single N-acetylglucosamine sugar from UDP-GlcNAc to the protein on serine and threonine residues on proteins. …”
Publicado 2023
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1850por Li, Jing, Bruns, Alexander-Francisco, Hou, Bing, Rode, Baptiste, Webster, Peter J., Bailey, Marc A., Appleby, Hollie L., Moss, Nicholas K., Ritchie, Judith E., Yuldasheva, Nadira Y., Tumova, Sarka, Quinney, Matthew, McKeown, Lynn, Taylor, Hilary, Prasad, K. Raj, Burke, Dermot, O’Regan, David, Porter, Karen E., Foster, Richard, Kearney, Mark T., Beech, David J.“…Shear stress reduced microsomal glutathione S-transferase 2 expression while inducing expression of leukotriene C(4) synthase, suggesting reciprocal regulation of leukotriene C(4)–synthesizing enzymes and greater role of microsomal glutathione S-transferase 2 in low shear stress. …”
Publicado 2015
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1851por Dar, Owias Iqbal, Sharma, Sunil, Singh, Kirpal, Sharma, Anket, Bhardwaj, Renu, Kaur, Arvinder“…Significant decline in protein, glutathione and acetylcholinesterase but increase in glutathione S-transferase, lactate dehydrogenase, aspartate transaminase, alanine transaminase, melondialdehyde and organic acids over control during exposure continued till the end of recovery period. …”
Publicado 2020
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1852por Liljeruhm, Josefine, Leppik, Margus, Bao, Letian, Truu, Triin, Calvo-Noriega, Maria, Freyer, Nicola S., Liiv, Aivar, Wang, Jinfan, Blanco, Rubén Crespo, Ero, Rya, Remme, Jaanus, Forster, Anthony C.“…However, a major growth defect was reported for deletion of the RlmE enzyme, which abolished a 2′O methylation near the peptidyl transferase center (PTC) of the 23S rRNA. Additionally, an adjacent 80-nt “critical region” around the PTC had to be modified to yield significant peptidyl transferase activity in vitro. …”
Publicado 2022
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1853por Mills, Elena, Price, Helen P., Johner, Andrea, Emerson, Jenny E., Smith, Deborah F.“…Bioinformatic analyses have been used to identify potential downstream targets of the essential enzyme N-myristoyl transferase in the TriTryp species, Leishmania major, Trypanosoma brucei and Trypanosoma cruzi. …”
Publicado 2007
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1854“…GlnD, a uridylyl transferase, is involved in the control of GlnE activity in other bacteria. …”
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1855Publicado 1982“…The distribution of galactosyl transferase was studied using trans and cis Golgi fractions isolated by a modification of the Ehrenreich et al. procedure (1973. …”
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1856“…Furthermore, the glycine and serine residues represent those at the corresponding position of the human blood group A and B transferases with GalNAc and galactose specificity, respectively, implicating the crucial role the glycine residue may play in the FS α1,3-GalNAc transferase activity.…”
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1857“…KEY WORD S chronic alcoholic hepatitis; glutathione peroxidase; glutathione reductase; reduced glutathione; glutathione-S-transferase; caspases; melaxen.…”
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1858“…Glutathione metabolism, in which glutathione synthetase and glutathione S-transferase are closely related to Cd stress, is identified in the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. …”
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1859por Bhattacharya, Prabuddha, Singha, Monisha, Senapati, Kalyan, Saha, Suman, Mandal, Sudipa, Mandal, Santi M., Ghosh, Ananta K., Basak, Amit“…Activity profiling against P. aeruginosa strain EXR1 with catB gene indicated the inability of acetyl transferase to acetylate the chloramphenicol-borate/boronate complex, unlike chloramphenicol. …”
Publicado 2018
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1860por Esterhuizen, Maranda, Lutsko, Mariia, Kim, Youngsam, Yoon, Hakwon, Park, Chang-Beom, Kim, Young Jun, Pflugmacher, Stephan“…Microsomal glutathione S-transferase was unaffected by diclofenac exposure but inhibited with titanium dioxide and the mixture. …”
Publicado 2023
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