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  1. 1001
    “…Tramadol is widely used globally and is the second most prescribed opioid in the United States. …”
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    Desmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist
  2. 1002
    “…The patients could also use a patient-controlled analgesia (PCA) pump to self-inject a tramadol bolus each time he/she felt pain. The primary outcome was the cumulative tramadol consumption over the 48 h after surgery. …”
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    Effects of Different 0.2% Ropivacaine Infusion Regimens for Continuous Interscalene Brachial Plexus Block on Postoperative Analgesia and Respiratory Function After Shoulder Arthroscopic Surgery: A Randomized Clinical Trial
  3. 1003
    “…The time of the first dose of rescue analgesia and total tramadol consumption for 24 h postoperatively were secondary objectives. …”
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    Comparison between peripheral nerve stimulator-guided serratus anterior plane block versus transversus abdominis plane block for postoperative analgesia in laparoscopic cholecystectomy under general anaesthesia: A double-blind randomised controlled trial
  4. 1004
    “…All patients were given 50 mg of tramadol intravenously 30 minutes before the procedure. …”
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    Effect of Oral Administration of Acetaminophen and Topical Application of EMLA on Pain during Transrectal Ultrasound-Guided Prostate Biopsy
  5. 1005
    “…The patients were given tramadol as a rescue medication option. The total volume of tramadol that was injected was also evaluated over the same intervals. …”
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    Effects of interscalene brachial plexus block to intra-operative hemodynamics and postoperative pain for arthroscopic shoulder surgery
  6. 1006
    “…Patients undergoing TAP block had reduced tramadol requirement in 24 h (210.05 ± 20.5 vs. 320.05 ± 10.6; P < 0.01) and 48 h (508.25 ± 20.6 vs. 550.25 ± 20.6; P < 0.01), and a longer time to the first PCA tramadol request (in minutes), compared to the control group (178.5 ± 45.6 vs. 23.5 ± 3.8; P < 0.001). …”
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    Evaluation of postoperative analgesic efficacy of transversus abdominis plane block after abdominal surgery: A comparative study
  7. 1007
    “…CONCLUSIONS: We demonstrated that the antinociceptive effect of morphine but not tramadol was reduced in mice that had experienced UCMS. …”
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    Amelioration of the reduced antinociceptive effect of morphine in the unpredictable chronic mild stress model mice by noradrenalin but not serotonin reuptake inhibitors
  8. 1008
    “…Epidurally 0.25% bupivacaine along with 10 mg nalbuphine (group A) or tramadol 100 mg (group B) diluted to 2 ml to make a total volume of 10 ml was administered at sensory regression to T10. …”
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    Epidural nalbuphine for postoperative analgesia in orthopedic surgery
  9. 1009
    “…A higher proportion of the patients in the co-morbid group required tramadol as a second-line of agent for pain relief.…”
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    Effect of Co-Morbid Conditions on Persistent Neuropathic Pain after Brachial Plexus Injury in Adult Patients
  10. 1010
    “…The most common substances present in all the samples were as follows: diphenoxylate, tramadol, opioids, acetaminophen, and codeine with values of 90%, 86%, 78%, 69%, and 68%, respectively. …”
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    Component Analysis of the Illegal Handmade Pills and Capsules for Self-Medicating Substance Dependence in Tehran, Iran
  11. 1011
    “…While there was no difference in Numeric Rating Scale (NRS) score at any hour between the block groups; NRS scores at the 1(st), 3(rd) and 6(th) h, tramadol consumption during the first 12 h and total tramadol consumption, the number of patient required rescue analgesic in 24 h were significantly higher in the control group compared to both block groups. …”
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    Comparison of Ultrasound-Guided Lumbar Erector Spinae Plane Block and Transmuscular Quadratus Lumborum Block for Postoperative Analgesia in Hip and Proximal Femur Surgery: A Prospective Randomized Feasibility Study
  12. 1012
    “…A urine sample was screened by dipstick kits for the following drug abuse tramadol, opiate, tetrahydrocannabinol (cannabis), amphetamine, barbiturate, cocaine, and benzodiazepines. …”
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    Evaluation of Drug Abuse in Patients With Lifelong Premature Ejaculation: A Cross-Sectional Study
  13. 1013
    “…Among them, the consumption of tramadol, step II (tramadol excluded) and step III opioids was 1.8, 1.3 and 0.3 % respectively in 2013 and 4.3, 3.4 and 1.9% in 2018 (p < 0.03). …”
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    Impact of Opioid Consumption in Patients With Functional Gastrointestinal Disorders
  14. 1014
    “…The total postoperative dosage of tramadol hydrochloride, length of hospitalization, quality of life (QoL), and inflammation levels were recorded. …”
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    Ultrasound-Guided Thoracic Paravertebral Nerve Block on Postoperative Pain, Quality of Life, and Recovery in Patients with Non-Small-Cell Lung Cancer
  15. 1015
    “…Past tramadol and strong opioid use in current users increased the risk of the sustained use of tramadol and strong opioids 1.45-fold (adjusted rate ratio [aRR]; 95% confidence interval [CI], 1.12–1.87; P = 0.004) and 1.65-fold (aRR; 95% CI, 1.43–1.91; P < 0.001), respectively, compared to past non-users. …”
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    Effect of Opioids on All-cause Mortality and Opioid Addiction in Total Hip Arthroplasty: a Korea Nationwide Cohort Study
  16. 1016
    “…The rate of suicide was more in the tramadol group, while the past history of psychological problems was more observed in the methadone group (P < 0.0001). …”
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    Common Opioids Involved in Drug Poisoning Presenting to the Emergency Department: A Cross-sectional Study
  17. 1017
    “…Group 2 (37 patients) received intravenous opioids analgesia with morphine 20–25 mg/day or tramadol 200–300 mg/day. The primary outcomes were: the pain perceived: Critical-Care Pain Observation Tool (CPOT) score; the opioids consumption: mg morphine or tramadol, or µg sufentanyl administered; and mg paracetamol, toradol, tramadol or morphine administered as a rescue. …”
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    Ultrasound-Guided PECS II + Serratus Plane Fascial Blocks Are Associated with Reduced Opioid Consumption and Lengths of Stay for Minimally Invasive Cardiac Surgery: An Observational Retrospective Study
  18. 1018
    “…Second group received after operation tramadol 1 mg.kg(−1)/6 h as standard hospital analgesia protocol. …”
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    Subcostal transversus abdominis plane block can improve analgesia after laparoscopic cholecystectomy
  19. 1019
    “…They were given ultrasound-guided FICB with 30 mL 0.2% ropivacaine for postoperative analgesia using the respective approaches. Injection tramadol was administered as a rescue analgesic when Numeric Rating Scale (NRS) ≥4. …”
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    Comparison of suprainguinal approach with infrainguinal approach of fascia iliaca compartment block for postoperative analgesia
  20. 1020
    “…RESULTS: In comparison of all groups with each other, lower pain scores were shown at 1 h and 8 h after surgery in Morphine group versus Tramadol, Fentanyl and Control groups (P < 0.05). Both Tramadol and Fentanyl groups showed lower pain scores in comparison to Control group (P < 0.05). …”
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    Postoperative analgesia for pediatric craniotomy patients: a randomized controlled trial
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