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84Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinonespor Harnden, Alice C., Davis, Owen A., Box, Gary M., Hayes, Angela, Johnson, Louise D., Henley, Alan T., de Haven Brandon, Alexis K., Valenti, Melanie, Cheung, Kwai-Ming J., Brennan, Alfie, Huckvale, Rosemary, Pierrat, Olivier A., Talbot, Rachel, Bright, Michael D., Akpinar, Hafize Aysin, Miller, Daniel S. J., Tarantino, Dalia, Gowan, Sharon, de Klerk, Selby, McAndrew, Peter Craig, Le Bihan, Yann-Vaï, Meniconi, Mirco, Burke, Rosemary, Kirkin, Vladimir, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Bellenie, Benjamin R., Hoelder, Swen“…Here, we report the optimization of our previously reported tricyclic quinolinone series for the inhibition of BCL6. …”
Publicado 2023
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85Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channelpor Renda, Mario, Barreca, Marilia, Borrelli, Anna, Spanò, Virginia, Montalbano, Alessandra, Raimondi, Maria Valeria, Bivacqua, Roberta, Musante, Ilaria, Scudieri, Paolo, Guidone, Daniela, Buccirossi, Martina, Genovese, Michele, Venturini, Arianna, Bandiera, Tiziano, Barraja, Paola, Galietta, Luis J. V.“…Tricyclic pirrolo-quinolines may represent novel CFTR correctors suitable for combinatorial pharmacological treatments to treat the basic defect in CF.…”
Publicado 2023
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86por Mu, Wenqing, Xu, Guang, Wang, Zhilei, Li, Qiang, Sun, Siqiao, Qin, Qin, Li, Zhiyong, Shi, Wei, Dai, Wenzhang, Zhan, Xiaoyan, Wang, Jiabo, Bai, Zhaofang, Xiao, Xiaohe“…Increasing evidence show that tricyclic antidepressants (TCAs) can induce IDILI in clinical applications but the underlying mechanisms are still poorly understood. …”
Publicado 2023
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87por Sekhon, Inderpal, Chen, Guanglin, Piri, Keyara, Shinkawa, Seiji, Ashong, Dennis, Zhang, Qiang, Wang, Guangdi, Chen, Qiao-Hong“…Encouraged by the fact that tricyclic aromatic diterpenoid QW07 has recently been established as a potential N-terminal AR antagonist, this study aims to explore the structure–activity relationship of tricyclic diterpenoids and their potential to suppress AR-positive cell proliferation. …”
Publicado 2023
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90por Drabczyńska, Anna, Karcz, Tadeusz, Szymańska, Ewa, Köse, Meryem, Müller, Christa E., Paskaleva, Minka, Karolak-Wojciechowska, Janina, Handzlik, Jadwiga, Yuzlenko, Olga, Kieć-Kononowicz, Katarzyna“…Syntheses and biological activities of imidazo-, pyrimido- and diazepino[2,1-f]purinediones containing N-alkyl substituents (with straight, branched or unsaturated chains) are described. Tricyclic derivatives were synthesized by the cyclization of 8-bromo-substituted 7-(2-bromoethyl)-, 7-(3-chloropropyl)- or 7-(4-bromobutyl)-theophylline with primary amines under various conditions. …”
Publicado 2013
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91“…[Image: see text] A synthesis of the ABC tricyclic ring system of the clionastatins, an unusual pair of highly chlorinated androstane steroids, has been accomplished. …”
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92por Ranatunga, Sujeewa, Tang, Chih-Hang Anthony, Kang, Chang Won, Kriss, Crystina L., Kloppenburg, Bernhard J., Hu, Chih-Chi Andrew, Del Valle, Juan R.Enlace del recurso
Publicado 2014
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93por Molana, Aliasghar, Mehrpour, Masoud, Vousooghi, Nasim, Hajighasem, Mahmoud Reza, Joghataei, Mohammad Taghi“…One class of medications used as first-line treatment in migraine prophylaxis is tricyclic antidepressants (TCAs). The aim of this study was to determine effects of NOS3 gene Glu298Asp polymorphism in the production of NO and response of patients to TCAs in migraine attacks. …”
Publicado 2014
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94por Schwartz, Brett D., Coster, Mark J., Skinner-Adams, Tina S., Andrews, Katherine T., White, Jonathan M., Davis, Rohan A.“…Six regioisomers associated with the tricyclic core of thiaplakortones A–D have been synthesized. …”
Publicado 2015
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95por Pottegård, Anton, García Rodríguez, Luis Alberto, Rasmussen, Lotte, Damkier, Per, Friis, Søren, Gaist, David“…BACKGROUND: A protective effect of tricyclic antidepressants (TCAs) against gliomas has been suggested by a small number of studies. …”
Publicado 2016
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96por Bahrin, Lucian G, Hopf, Henning, Jones, Peter G, Sarbu, Laura G, Babii, Cornelia, Mihai, Alina C, Stefan, Marius, Birsa, Lucian M“…A structure–activity relationship study concerning the antibacterial properties of several halogen-substituted tricyclic sulfur-containing flavonoids has been performed. …”
Publicado 2016
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97por Gündüz, Miyase Gözde, Kaya, Yesim, Şimşek, Rahime, Sahin-Erdemli, Inci, Şafak, Cihat“…The present study reports a microwave-assisted method for the synthesis of twelve novel tricyclic 1,4-dihydropyridine derivatives in which dimethyl-substituted cyclohexane and / or tetrahydrothiophene rings are fused to the DHP ring. …”
Publicado 2016
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98por Maezawa, Izumi, Zou, Bende, Di Lucente, Jacopo, Cao, William S., Pascual, Conrado, Weerasekara, Sahani, Zhang, Man, Xie, Xinmin Simon, Hua, Duy H., Jin, Lee-Way“…We have taken a rational design approach and synthesized a class of tricyclic pyrone (TP) compounds that show anti-Aβ and other neuroprotective actions. …”
Publicado 2017
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99“…The tricyclic antidepressants, while older, still have their place in the treatment of depression today. …”
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100“…Tricyclic antidepressants are known as potentially inappropriate medications in the elderly. …”
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