Mostrando 28,521 - 28,540 Resultados de 33,296 Para Buscar 'Wallern~', tiempo de consulta: 1.45s Limitar resultados
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    “…Here, we demonstrate a unique protumorigenic niche in the livers of Ncoa5(+/−) mouse model of HCC, which is characterized by altered expression of a subset of genes including p21(WAF1/CIP1) and proinflammatory cytokine genes, increased putative hepatic progenitors, and expansions of activated and tissue-resident memory (TRM) CD8+ T lymphocytes, myeloid-derived suppressor cells (MDSCs) and alternatively activated M2 macrophages. Importantly, prophylactic metformin treatment reversed these characteristics including aberrant p21(WAF1/CIP1) expression and subsequently reduced HCC incidence in Ncoa5(+/−) male mice. …”
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