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1521“…Eight individuals with allergic contact dermatitis to a variety of allergens were studied and six of these developed typical contact reactions with erythema, edema, and epidermal vesicles. …”
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1522
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1523
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1524“…Alternative splicing is thought to be one of the major sources for functional diversity in higher eukaryotes. …”
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1525“…Immunomodulation is the key to a successful treatment of allergic and autoimmune conditions.…”
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1526“…The history of allergic disease goes back to 1819, when Bostock described his own ‘periodical affection of the eyes and chest’, which he called ‘summer catarrh’. …”
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1527
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1528por Lev-Maor, Galit, Ram, Oren, Kim, Eddo, Sela, Noa, Goren, Amir, Levanon, Erez Y., Ast, Gil“…Here, we show that more Alus flank alternatively spliced exons than constitutively spliced ones; this is especially notable for those exons that have changed their mode of splicing from constitutive to alternative during human evolution. …”
Publicado 2008
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1529por Sinha, Rileen, Nikolajewa, Swetlana, Szafranski, Karol, Hiller, Michael, Jahn, Niels, Huse, Klaus, Platzer, Matthias, Backofen, Rolf“…Alternative splicing (AS) involving NAGNAG tandem acceptors is an evolutionarily widespread class of AS. …”
Publicado 2009
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1530por Ahmed, Asad“…To explain this anomaly, a model is presented in which the two mechanisms are not independent—as widely believed—but could represent alternate outcomes of a common transpositional pathway.…”
Publicado 2009
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1531“…The goal of this work was to reproduce the multiple projections phenotype in the absence of α-factor using a gain-of-function approach termed “Alternative Inputs (AIs)”. An alternative input is defined as any genetic manipulation that can activate the signaling pathway instead of the natural input. …”
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1532por Katsumata, N“…While paclitaxel–carboplatin remains the standard treatment for the management of advanced ovarian cancer, docetaxel–carboplatin appears to be a promising alternative, particularly in terms of minimising the incidence and severity of peripheral neuropathy.…”
Publicado 2003
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1534por Min, Yang-Gi“…For the mechanisms of AR, anti-IgE antibody and specific antibody to cytokines such as IL-4 or IL-5 that correlate with allergic inflammation have recently emerged. SLIT is currently widely used due to its efficacy, safety and convenience, which replaces subcutaneous immunotherapy. …”
Publicado 2010
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1535por Chang, Moon Young, Han, Doo Hee, Moon, Il Joon, Kim, Seung-Tae, Kim, Dong-Young, Lee, Chul Hee, Min, Yang-Gi, Rhee, Chae-Seo“…OBJECTIVES: The internet has become an important source of medical information and a great amount of information related to allergic rhinitis (AR) is available on the internet. …”
Publicado 2010
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1536“…Gene expression is regulated not only at the level of transcription but also through alternative splicing of pre-mRNA. In this review, we discuss some of the evidence suggesting that alternative splicing of candidate genes such as DRD2 (encoding dopamine D2 receptor) may form the basis of the mechanisms underlying the pathophysiology of alcoholism. …”
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1537por Nygard, Ann-Britt, Cirera, Susanna, Gilchrist, Michael J, Gorodkin, Jan, Jørgensen, Claus B, Fredholm, Merete“…BACKGROUND: Since at least half of the genes in mammalian genomes are subjected to alternative splicing, alternative pre-mRNA splicing plays an important contribution to the complexity of the mammalian proteome. …”
Publicado 2010
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1538“…Most currently used tic-suppressing drugs are frequently associated with serious adverse events. Thus, alternative therapeutic agents with more favorable side-effect profiles are being evaluated. …”
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